HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Gene: CDC34

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	25527291, 30097011, 36758106, 37558718, 22069333, 17597759, 24912152
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 236
+	Hs
		647586 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2R2_HUMAN (1-203): 2.28e-79: 239: 84.73
+	Oc
		1177142 UBA1_RABIT (1-1058): 0: 1356: 96.69		UB2R2_RABIT (1-203): 2.28e-79: 239: 84.73
+	Hs
		647684 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (9-167): 7.3e-72: 217: 32.50
+	Hs
		647506 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (9-167): 6.22e-71: 215: 34.38
+	Hs
		647533 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (9-167): 6.29e-71: 215: 30.00
+	Hs
		647521 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (9-167): 8.84e-70: 212: 29.38
+	Hs
		647529 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2G1_HUMAN (8-176): 2.22e-68: 209: 47.93
+	Hs
		647520 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2G2_HUMAN (5-164): 2.35e-66: 204: 46.58
+	Hs
		647537 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (9-157): 5.39e-27: 103: 38.93
+	Hs
		647502 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (9-157): 1.04e-26: 102: 38.26
+	Dm
		1344410 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		Q8SYG3_DROME (1-176): 7.54e-68: 208: 45.46
+	Sp
		314596 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (9-166): 2.26e-70: 213: 30.19
+	Sp
		122416 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC7_SCHPO (1-174): 3.83e-67: 206: 42.53
+	Sp
		314600 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC15_SCHPO (7-155): 2.1e-65: 201: 48.99
+	Sc
		574773 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC3_YEAST (7-232): 1.7e-66: 209: 34.35
+	Sc
		585681 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (8-166): 1.18e-68: 209: 31.88
+	Sc
		649516 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC7_YEAST (5-157): 2.53e-65: 201: 45.75
+	Hs
		48347 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (9-167): 6.22e-71: 215: 34.38
+	Sp
		122418 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC11_SCHPO (8-150): 7.56e-27: 103: 39.16
+	Sp
		314595 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (8-169): 4.42e-27: 103: 35.19