Protein: Q8SYG3
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)

Gene: Q8SYG3, BcDNA:RE63412
Organism: Drosophila melanogaster
Interactions: 141
UniProt ID: Q8SYG3

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0061631 - ubiquitin conjugating enzyme activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1344410

Q8T0L3
E1 ubiquitin-activating enzyme

1

20

High-throughput

0.575

High

1344468

Q9VRL1
GEO06356p1

1

16

High-throughput

0.575

High

1344438

IPO9
Importin-9

1

6

High-throughput

0.514

High

652056

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

1

High-throughput

0.445

High

874985

PRS4
26S proteasome regulatory subunit 4

1

3

High-throughput

0.445

High

875233

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.445

High

1070095

Q0E9E2
Pyruvate carboxylase

1

2

High-throughput

0.445

High

1176278

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

1

High-throughput

0.445

High

1264116

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1265790

Q7K3J0
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

1267248

Q7KKI0
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.445

High

1267691

Q7KMQ0
26S proteasome regulatory subunit 7

1

2

High-throughput

0.445

High

1267899

TERA
Transitional endoplasmic reticulum ATPase TER94

1

2

High-throughput

0.445

High

1268072

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.445

High

1343301

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.445

High

1344412

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.445

High

1344416

Q9V3V6
26S proteasome regulatory complex subunit p50

1

5

High-throughput

0.445

High

1344420

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1344421

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.445

High

1344422

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.445

High

1344426

Q9VAH7
N-terminal kinase-like protein

1

3

High-throughput

0.445

High

1344441

Q9VHL2
T-complex protein 1 subunit eta

1

3

High-throughput

0.445

High

1344447

Q9VK69
T-complex protein 1 subunit delta

1

2

High-throughput

0.445

High

1344450

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

1

High-throughput

0.445

High

1344457

SYAC
Alanine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.445

High

1344465

Q9VQL1
serine--tRNA ligase

1

6

High-throughput

0.445

High

1344473

Q9VU35
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.445

High

1344474

Q9VUC1
Hsc70Cb, isoform A

1

9

High-throughput

0.445

High

1344479

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.445

High

1344486

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

5

High-throughput

0.445

High

1344492

Q9W392
T-complex protein 1 subunit beta

1

6

High-throughput

0.445

High

1344497

Q9W414
Regulatory particle triple-A ATPase 4

1

2

High-throughput

0.445

High

197520

SPS1
Inactive selenide, water dikinase-like protein

1

0

High-throughput

0.426

High

556699

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.426

High

632962

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

726377

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

1031208

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

1344418

Q9V3Z4
GH11341p

1

0

High-throughput

0.426

High

1344446

Q9VK56
ABC-type glutathione-S-conjugate transporter

1

0

High-throughput

0.426

High

86514

B9EQV3
Endoplasmic reticulum transmembrane protein

1

2

High-throughput

0.407

High

121250

ALDR
Aldo-keto reductase 1B

1

2

High-throughput

0.407

High

234583

VINC
Vinculin

1

2

High-throughput

0.407

High

304225

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.407

High

426709

HP1
Heterochromatin protein 1

1

4

High-throughput

0.407

High

460078

ALF
Fructose-bisphosphate aldolase

1

2

High-throughput

0.407

High

648905

ANXB9
Annexin B9

1

4

High-throughput

0.407

High

682767

PROF
Profilin

1

1

High-throughput

0.407

High

715118

CLH
Clathrin heavy chain

1

1

High-throughput

0.407

High

782737

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

3

High-throughput

0.407

High

834855

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.407

High

835155

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.407

High

856043

MOEH
Moesin/ezrin/radixin homolog 1

1

2

High-throughput

0.407

High

928984

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

2

High-throughput

0.407

High

930158

VATE
V-type proton ATPase subunit E

1

2

High-throughput

0.407

High

1052239

HMGD
High mobility group protein D

1

1

High-throughput

0.407

High

1059154

ROP
Protein ROP

1

2

High-throughput

0.407

High

1071026

Q0KIB3
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.407

High

1261532

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.407

High

1268702

CCD1D
Probable cytochrome P450 12d1 distal, mitochondrial

1

3

High-throughput

0.407

High

1303899

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.407

High

1305711

Q8IQZ7
FI19014p1

1

3

High-throughput

0.407

High

1342996

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

1

High-throughput

0.407

High

1344411

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.407

High

1344415

Q9V3V2
peptidylprolyl isomerase

1

4

High-throughput

0.407

High

1344423

Q9V9Q4
LD43819p

1

1

High-throughput

0.407

High

1344424

Q9V9S0
FI04419p

1

2

High-throughput

0.407

High

1344430

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

1344431

Q9VD29
small monomeric GTPase

1

10

High-throughput

0.407

High

1344433

FLNA
Filamin-A

1

3

High-throughput

0.407

High

1344437

Q9VGK3
peptidylprolyl isomerase

1

4

High-throughput

0.407

High

1344439

Q9VH81
protein-serine/threonine phosphatase

1

6

High-throughput

0.407

High

1344440

TEBPH
Cytosolic Prostaglandin E synthase

1

4

High-throughput

0.407

High

1344442

Q9VHN7
transketolase

1

2

High-throughput

0.407

High

1344443

ARL8
ADP-ribosylation factor-like protein 8

1

9

High-throughput

0.407

High

1344444

Q9VI53
LD44267p

1

2

High-throughput

0.407

High

1344445

Q9VJD1
Glucosidase 2 subunit beta

1

1

High-throughput

0.407

High

1344448

NFS1
Cysteine desulfurase, mitochondrial

1

1

High-throughput

0.407

High

1344449

Q9VKW5
Prolyl endopeptidase

1

1

High-throughput

0.407

High

1344451

EF1D
Probable elongation factor 1-delta

1

2

High-throughput

0.407

High

1344452

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

3

High-throughput

0.407

High

1344453

Q9VL70
HL08109p

1

2

High-throughput

0.407

High

1344454

FKB59
FK506-binding protein 59

1

4

High-throughput

0.407

High

1344455

Q9VLB7
Rab GDP dissociation inhibitor

1

2

High-throughput

0.407

High

1344456

AK200
A-kinase anchor protein 200

1

6

High-throughput

0.407

High

1344460

Q9VN44
FI07923p

1

3

High-throughput

0.407

High

1344461

Q9VPN5
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.407

High

1344463

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.407

High

1344466

Q9VQL7
Fatty acid synthase

1

1

High-throughput

0.407

High

1344467

Q9VRD6
NTF2-related export protein

1

1

High-throughput

0.407

High

1344471

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

1344472

Q9VTY2
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

1344475

FRL
Formin-like protein

1

1

High-throughput

0.407

High

1344476

Q9VV75
AT02348p

1

1

High-throughput

0.407

High

1344480

Q9VW59
Rho GDP-dissociation inhibitor 3

1

1

High-throughput

0.407

High

1344481

RS10B
Small ribosomal subunit protein eS10B

1

3

High-throughput

0.407

High

1344482

Q9VWI2
N(Alpha)-acetyltransferase 15/16, isoform A

1

1

High-throughput

0.407

High

1344483

Q9VWL0
Mec2

1

1

High-throughput

0.407

High

1344484

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.407

High

1344487

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.407

High

1344488

ETIF1
Eukaryotic translation initiation factor eIF1

1

1

High-throughput

0.407

High

1344489

Q9W0E4
Aminopeptidase

1

2

High-throughput

0.407

High

1344491

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.407

High

1344493

Q9W3N1
RH59310p

1

4

High-throughput

0.407

High

1344496

CISY
Probable citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

1344417

Q9V3Y7
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

1344429

Q9VBP2
GH01133p

1

0

High-throughput

0.265

Low

1344459

CUP
Protein cup

1

0

High-throughput

0.265

Low

1344499

X2JD70
Troponin C at 25D, isoform B

1

0

High-throughput

0.249

Low

53685

A1Z843
Nodal modulator 3

1

0

High-throughput

0.232

Low

57580

A1ZB71
Glutathione S transferase E6

1

0

High-throughput

0.232

Low

57801

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

305672

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.232

Low

357531

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.232

Low

762570

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

1236864

Q6NP35
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.232

Low

1260816

Q76NR6
Regucalcin

1

0

High-throughput

0.232

Low

1262675

Q7JWV7
Tetraspanin

1

0

High-throughput

0.232

Low

1306090

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.232

Low

1321662

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.232

Low

1344413

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.232

Low

1344414

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

1344419

API5
Apoptosis inhibitor 5 homolog

1

0

High-throughput

0.232

Low

1344425

Q9VAC1
GM14349p

1

0

High-throughput

0.232

Low

1344427

Q9VAN7
Phosphoglycerate mutase

1

0

High-throughput

0.232

Low

1344428

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

0

High-throughput

0.232

Low

1344432

Q9VEB1
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

1344434

ELP6
Elongator complex protein 6

1

0

High-throughput

0.232

Low

1344435

Q9VG31
Malic enzyme

1

0

High-throughput

0.232

Low

1344436

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1344458

Q9VM57
Septin interacting protein 2, isoform A

1

0

High-throughput

0.232

Low

1344462

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

1344464

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.232

Low

1344469

Q9VS47
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.232

Low

1344470

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

1344477

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

1344478

Q9VVL7
Dihydrolipoyl dehydrogenase

1

0

High-throughput

0.232

Low

1344485

SUN
Protein stunted

1

0

High-throughput

0.232

Low

1344490

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.232

Low

1344494

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low

1344495

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1344498

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025