HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC9 (P50623)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (Ubiquitin carrier protein 9) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC9

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21209884
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 157
+	Hs
		647684 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D4_HUMAN (4-156): 2.18e-75: 223: 33.33
+	Hs
		647506 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D1_HUMAN (4-156): 1.2e-74: 221: 33.99
+	Hs
		647533 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D2_HUMAN (4-156): 2.56e-74: 220: 32.68
+	Hs
		647521 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2D3_HUMAN (4-156): 3.19e-73: 217: 32.68
+	Hs
		647626 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E2_HUMAN (3-156): 2.99e-69: 209: 31.17
+	Hs
		647538 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBC9_HUMAN (1-156): 1.26e-69: 208: 56.41
+	Hs
		647619 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E3_HUMAN (3-156): 6.7e-69: 208: 31.17
+	Hs
		647508 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UB2E1_HUMAN (3-156): 2.88e-67: 204: 31.82
+	Hs
		647502 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2A_HUMAN (1-154): 2.59e-67: 203: 38.96
+	Hs
		647537 UBA1_HUMAN (2-1023): 0: 1129: 51.55		UBE2B_HUMAN (1-154): 1.17e-66: 201: 38.31
+	Sc
		585681 UBA1_YEAST (1-1024): 0: 1092: 100.00		UBC4_YEAST (1-156): 2.8e-73: 217: 33.33
+	Sp
		314596 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC4_SCHPO (4-156): 2.89e-73: 217: 33.33
+	Hs
		48347 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D1_HUMAN (4-156): 1.2e-74: 221: 33.99
+	Hs
		48351 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D2_HUMAN (4-156): 2.56e-74: 220: 32.68
+	Hs
		48349 UBA6_HUMAN (2-1024): 0: 974: 40.71		UB2D3_HUMAN (4-156): 3.19e-73: 217: 32.68
+	Sp
		122416 UBA1_SCHPO (1-1024): 0: 1045: 58.19		UBC7_SCHPO (3-154): 1.68e-25: 97.1: 33.74
+	Hs
		833587 UBA7_HUMAN (5-1024): 0: 913: 37.09		UB2E1_HUMAN (3-156): 2.88e-67: 204: 31.82
+	At
		1192766 SAE2_ARATH (31-482): 1.21e-78: 273: 16.31		SCE1_ARATH (2-155): 2.61e-73: 218: 59.74
+	Hs
		1381215 SAE2_HUMAN (24-440): 1.02e-74: 261: 16.14		UB2E3_HUMAN (3-156): 6.7e-69: 208: 31.17
+	Hs
		993787 SAE2_HUMAN (24-440): 1.02e-74: 261: 16.14		UBC9_HUMAN (1-156): 1.26e-69: 208: 56.41