HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	17289590, 19914168, 18045539
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 465
+	Hs
		658889 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		658931 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		167368 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		SMAD7_HUMAN (30-131): 2.89e-25: 109: 32.46