HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	28065597
Identification Methods	ubiquitin reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 583
+	Hs
		658955 PTPRE_HUMAN (130-802): 0: 834: 66.81		SHC1_HUMAN (1-583): 0: 529: 100.00
+	Mm
		883404 PTPRE_MOUSE (107-802): 0: 824: 65.19		SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51
+	Hs
		222016 PTPRA_HUMAN (1-802): 0: 1038: 100.00		NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83
+	Hs
		614690 PTPRA_HUMAN (1-802): 0: 1038: 100.00		SHB_HUMAN (369-579): 1.33e-41: 159: 20.63
+	Hs
		614654 PTPRA_HUMAN (1-802): 0: 1038: 100.00		P85A_HUMAN (300-581): 8.31e-38: 151: 15.31
+	Mm
		72843 PTPRS_MOUSE (5-799): 0: 927: 38.96		ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41
+	Hs
		614675 PTPRA_HUMAN (1-802): 0: 1038: 100.00		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Mm
		611452 PTPRA_MOUSE (1-802): 0: 1001: 90.69		GRB2_MOUSE (482-578): 3.55e-15: 76.8: 30.48
+	Hs
		522697 PTPRF_HUMAN (4-799): 0: 892: 40.52		SH2D3_HUMAN (333-582): 1.16e-39: 156: 23.55
+	Hs
		658872 PTPRD_HUMAN (38-799): 0: 894: 40.50		BMX_HUMAN (341-582): 1.13e-38: 153: 19.69
+	Hs
		658960 PTPRE_HUMAN (130-802): 0: 834: 66.81		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Hs
		699756 PTPRK_HUMAN (14-794): 0: 754: 32.41		P85A_HUMAN (300-581): 8.31e-38: 151: 15.31
+	Hs
		155413 PTPRT_HUMAN (51-795): 0: 774: 31.14		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Hs
		584482 PTN6_HUMAN (504-796): 2.35e-112: 356: 32.47		VAV_HUMAN (154-578): 2.52e-55: 202: 11.97
+	Hs
		699599 PTN6_HUMAN (504-796): 2.35e-112: 356: 32.47		P85A_HUMAN (300-581): 8.31e-38: 151: 15.31
+	Hs
		593922 PTN4_HUMAN (515-795): 1.46e-102: 339: 34.15		NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30
+	Hs
		699594 PTN4_HUMAN (515-795): 1.46e-102: 339: 34.15		P85A_HUMAN (300-581): 8.31e-38: 151: 15.31
+	Hs
		987595 PTPRJ_HUMAN (516-797): 4.65e-118: 389: 38.87		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Hs
		711089 PTN6_HUMAN (504-796): 2.35e-112: 356: 32.47		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48
+	Hs
		708843 PTN4_HUMAN (515-795): 1.46e-102: 339: 34.15		GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48