HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: CKS1 (Q24152)
Cyclin-dependent kinases regulatory subunit
Gene: Cks30A

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	7809159
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 74
+	Dm
		660468 CDK2_DROME (1-314): 4.81e-139: 397: 100.00		Q9VHN1_DROME (2-72): 5.13e-38: 123: 64.79
+	Hs
		667697 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CKS1_HUMAN (3-71): 2.45e-35: 115: 78.26
+	Hs
		667577 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CKS2_HUMAN (3-71): 2.13e-33: 111: 78.26
+	Hs
		956646 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CKS1_HUMAN (3-71): 2.45e-35: 115: 78.26
+	Hs
		753913 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CKS2_HUMAN (3-71): 2.13e-33: 111: 78.26
+	Ce
		759628 CDK1_CAEEL (5-299): 2.31e-132: 380: 55.88		CKS1_CAEEL (2-71): 7.08e-40: 127: 62.86
+	At
		1423230 CDKD1_ARATH (2-309): 7.18e-132: 382: 41.10		CKS2_ARATH (4-71): 2.83e-36: 118: 69.12
+	At
		200085 CDKA1_ARATH (5-290): 1.18e-132: 380: 57.05		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	Hs
		443287 CDK1_HUMAN (5-292): 2.36e-134: 384: 56.85		CKS1_HUMAN (3-71): 2.45e-35: 115: 78.26
+	At
		663937 CDKA1_ARATH (5-290): 1.18e-132: 380: 57.05		CKS2_ARATH (4-71): 2.83e-36: 118: 69.12
+	Dm
		660384 CDK1_DROME (5-291): 3.72e-130: 373: 59.11		CKS1_DROME (1-74): 2.11e-38: 123: 100.00
+	Dm
		660412 CDK1_DROME (5-291): 3.72e-130: 373: 59.11		Q9VHN1_DROME (2-72): 5.13e-38: 123: 64.79
+	Hs
		956647 CDK5_HUMAN (5-293): 2.76e-133: 381: 49.32		CKS1_HUMAN (3-71): 2.45e-35: 115: 78.26
+	Hs
		443221 CDK1_HUMAN (5-292): 2.36e-134: 384: 56.85		CKS2_HUMAN (3-71): 2.13e-33: 111: 78.26
+	Hs
		753914 CDK5_HUMAN (5-293): 2.76e-133: 381: 49.32		CKS2_HUMAN (3-71): 2.13e-33: 111: 78.26
+	At
		200112 CDKD2_ARATH (5-305): 1.26e-128: 371: 42.38		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	At
		200117 CDKD3_ARATH (2-309): 1.03e-127: 371: 41.10		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	At
		1423183 CDKD2_ARATH (5-305): 1.26e-128: 371: 42.38		CKS2_ARATH (4-71): 2.83e-36: 118: 69.12
+	At
		1442071 CDKD3_ARATH (2-309): 1.03e-127: 371: 41.10		CKS2_ARATH (4-71): 2.83e-36: 118: 69.12
+	Sc
		364323 CDK1_YEAST (1-289): 8.71e-132: 378: 55.89		CKS1_YEAST (3-71): 1.08e-31: 108: 48.72