Protein: NEP1
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.260) (18S rRNA (pseudouridine(1189)-N1)-methyltransferase) (18S rRNA Psi1189 methyltransferase) (Essential for mitotic growth protein 1) (Nucleolar essential protein 1)

Gene: NEP1, EMG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: Q06287

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

986750

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

3

1

Small-scale

0.861

High

986754

NOC4
Nucleolar complex protein 4

6

1

Small-scale

0.730

High

986778

NOP14
Nucleolar complex protein 14

5

1

Small-scale

0.727

High

635649

PWP2
Periodic tryptophan protein 2

5

1

Small-scale

0.716

High

748710

ENP1
Essential nuclear protein 1

7

0

Small-scale

0.713

High

986774

NOP58
Nucleolar protein 58

4

1

High-throughput

0.694

High

634779

KRR1
KRR1 small subunit processome component

5

0

High-throughput

0.686

High

792589

UTP10
U3 small nucleolar RNA-associated protein 10

5

0

High-throughput

0.684

High

860745

UTP22
U3 small nucleolar RNA-associated protein 22

4

0

High-throughput

0.667

High

756791

UTP9
U3 small nucleolar RNA-associated protein 9

3

0

High-throughput

0.638

High

970471

UTP6
U3 small nucleolar RNA-associated protein 6

3

0

High-throughput

0.638

High

979029

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.613

High

775391

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

975837

TOM1
E3 ubiquitin-protein ligase TOM1

2

2

High-throughput

0.584

High

985813

UTP21
U3 small nucleolar RNA-associated protein 21

2

2

Small-scale

0.584

High

986756

UTP4
U3 small nucleolar RNA-associated protein 4

2

1

Small-scale

0.584

High

811562

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

0

Small-scale

0.559

High

865422

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

866058

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.559

High

979719

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

986767

RRP6
Exosome complex exonuclease RRP6

2

0

High-throughput

0.559

High

471266

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.533

High

434549

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

567601

PHO81
Phosphate system positive regulatory protein PHO81

1

0

High-throughput

0.513

High

766992

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.513

High

976928

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.513

High

986770

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.513

High

984560

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.486

High

361038

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

498598

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

562439

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.479

High

887683

ACT
Actin

1

0

High-throughput

0.479

High

733604

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.479

High

754196

CIC1
Proteasome-interacting protein CIC1

1

1

High-throughput

0.479

High

754998

RRP4
Exosome complex component RRP4

1

1

High-throughput

0.479

High

809590

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

860811

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

973676

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

978633

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.479

High

984310

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

985418

UTP13
U3 small nucleolar RNA-associated protein 13

1

2

High-throughput

0.479

High

986753

RRP9
Ribosomal RNA-processing protein 9

1

3

High-throughput

0.479

High

986755

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

986759

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

986769

UTP12
U3 small nucleolar RNA-associated protein 12

1

3

High-throughput

0.479

High

986771

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

986772

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

392578

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

480328

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

480894

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

524452

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

558267

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

593706

DBP4
ATP-dependent RNA helicase HCA4

1

0

High-throughput

0.458

High

628493

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

630263

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

630542

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

645663

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

663377

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

665063

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

688436

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

700100

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.458

High

706499

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

707142

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

711075

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

715986

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

754916

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.458

High

755203

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

758472

RRP8
25S rRNA

1

0

High-throughput

0.458

High

767424

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.458

High

768117

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

772679

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

774282

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

774752

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

799860

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

810922

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.458

High

816909

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

816976

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

861031

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

864438

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.458

High

864735

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

866491

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

866618

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

979242

UTP15
U3 small nucleolar RNA-associated protein 15

1

0

High-throughput

0.458

High

982877

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.458

High

983770

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

986751

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

986752

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

986757

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

986758

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

986761

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

986762

SGO1
Shugoshin

1

0

High-throughput

0.458

High

986763

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

986764

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

986765

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

986766

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

986768

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

986773

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

986775

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

986776

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

986779

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

512810

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

769532

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

986777

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.437

High

478541

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.426

High

342390

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.261

Low

381723

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

423916

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.261

Low

521060

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

986760

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

358268

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

745898

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

762578

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024