HitPredict

Interactor 1: PRTN3 (P24158)
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
Gene: PRTN3

Interactor 2: EGFL8 (Q99944)
Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2)
Gene: EGFL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~Trypsin
Common GO terms	GO:0005102 - signaling receptor binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 293
+	Hs
		437820 HEPS_HUMAN (7-248): 4.43e-91: 276: 27.94		EGFL7_HUMAN (16-285): 4.49e-46: 158: 33.82
+	Hs
		469442 ELNE_HUMAN (1-256): 5.08e-88: 263: 53.13		EGFL8_HUMAN (1-293): 1.15e-38: 139: 100.00
+	Hs
		317591 TMPS4_HUMAN (5-246): 4.1e-91: 277: 26.54		SLIT2_HUMAN (109-291): 2.97e-21: 95.6: 15.08
+	Hs
		452113 TMPSD_HUMAN (3-248): 1.18e-90: 280: 28.95		PROS_HUMAN (37-191): 5.42e-17: 82.9: 19.05
+	Hs
		437618 HEPS_HUMAN (7-248): 4.43e-91: 276: 27.94		PROS_HUMAN (37-191): 5.42e-17: 82.9: 19.05
+	Hs
		398001 KLKB1_HUMAN (17-255): 1.74e-96: 297: 27.06		FBN2_HUMAN (111-185): 4.67e-09: 59.4: 32.10
+	Hs
		1127605 TMPS4_HUMAN (5-246): 4.1e-91: 277: 26.54		FAT1_HUMAN (7-66): 1.92e-13: 72.9: 10.00
+	Hs
		437665 HEPS_HUMAN (7-248): 4.43e-91: 276: 27.94		NOTC2_HUMAN (6-210): 1.58e-10: 64: 10.66
+	Mm
		405588 GRAB_MOUSE (23-250): 2.84e-88: 263: 35.98		NOTC1_MOUSE (95-173): 7.88e-09: 58.6: 27.71
+	Hs
		518735 GRAB_HUMAN (23-250): 2.31e-85: 256: 38.49		NOTC1_HUMAN (95-173): 8.95e-09: 58.6: 27.71
+	Hs
		469829 CATG_HUMAN (22-248): 1.64e-41: 144: 37.55		EGFL8_HUMAN (1-293): 1.15e-38: 139: 100.00
+	Hs
		663544 CMA1_HUMAN (23-248): 3.94e-46: 155: 40.25		FAT1_HUMAN (7-66): 1.92e-13: 72.9: 10.00
+	Hs
		663554 CMA1_HUMAN (23-248): 3.94e-46: 155: 40.25		FAT4_HUMAN (3-59): 9.58e-13: 70.6: 8.77
+	Mm
		97996 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		E9Q440_MOUSE (111-176): 2.28e-22: 99.1: 40.85
+	Hs
		469787 CATG_HUMAN (22-248): 1.64e-41: 144: 37.55		FAT1_HUMAN (7-66): 1.92e-13: 72.9: 10.00
+	Hs
		634756 GRAH_HUMAN (22-250): 3.28e-41: 143: 37.08		FAT1_HUMAN (7-66): 1.92e-13: 72.9: 10.00
+	Hs
		634771 GRAH_HUMAN (22-250): 3.28e-41: 143: 37.08		FAT4_HUMAN (3-59): 9.58e-13: 70.6: 8.77
+	Mm
		398429 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		FBLN7_MOUSE (63-186): 8.52e-15: 76: 20.86
+	Mm
		99232 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		F2Z4A3_MOUSE (7-66): 4.44e-14: 74.4: 10.00
+	Mm
		204901 CFAD_MOUSE (10-245): 1.33e-33: 124: 34.52		NOTC2_MOUSE (71-223): 4.85e-11: 65.2: 14.88