HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	28007894
Identification Methods	affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 223
+	Hs
		703444 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS1_HUMAN (4-199): 4.07e-65: 207: 29.59
+	Hs
		703609 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS5_HUMAN (2-203): 1.3e-62: 201: 29.27
+	Hs
		691637 MK03_HUMAN (5-358): 3.39e-154: 440: 86.16		DUS1_HUMAN (4-199): 4.07e-65: 207: 29.59
+	Hs
		703689 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS9_HUMAN (3-191): 1.67e-61: 198: 28.13
+	Hs
		703565 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS4_HUMAN (12-201): 9.68e-61: 196: 28.80
+	Hs
		703611 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS7_HUMAN (16-188): 9.35e-59: 192: 30.46
+	Hs
		703698 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS16_HUMAN (7-186): 1.16e-56: 192: 27.22
+	Hs
		703549 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUSP2_HUMAN (9-175): 1.83e-59: 191: 36.05
+	Hs
		691726 MK03_HUMAN (5-358): 3.39e-154: 440: 86.16		DUS4_HUMAN (12-201): 9.68e-61: 196: 28.80
+	Hs
		703610 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS6_HUMAN (16-188): 2.92e-57: 187: 29.89
+	Mm
		989587 MK01_MOUSE (10-360): 4.52e-158: 449: 99.72		DUS6_MOUSE (16-179): 4.12e-57: 187: 30.49
+	Rn
		989644 MK01_RAT (10-360): 4.52e-158: 449: 99.72		DUS6_RAT (16-188): 2.92e-57: 187: 29.89
+	Hs
		703569 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS8_HUMAN (10-174): 2e-54: 185: 33.33
+	Mm
		989550 MK01_MOUSE (10-360): 4.52e-158: 449: 99.72		DUSP2_MOUSE (9-175): 2.29e-57: 185: 33.14
+	Hs
		691716 MK03_HUMAN (5-358): 3.39e-154: 440: 86.16		DUSP2_HUMAN (9-175): 1.83e-59: 191: 36.05
+	Hs
		703504 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS3_HUMAN (3-182): 1.02e-57: 182: 27.57
+	Mm
		989586 MK01_MOUSE (10-360): 4.52e-158: 449: 99.72		DUS3_MOUSE (3-182): 1.21e-56: 179: 26.49
+	Hs
		703659 MK01_HUMAN (1-360): 2.25e-158: 449: 100.00		DUS19_HUMAN (32-187): 3.45e-55: 177: 33.97
+	Hs
		691727 MK03_HUMAN (5-358): 3.39e-154: 440: 86.16		DUS8_HUMAN (10-174): 2e-54: 185: 33.33
+	Hs
		691683 MK03_HUMAN (5-358): 3.39e-154: 440: 86.16		DUS3_HUMAN (3-182): 1.02e-57: 182: 27.57