HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	8940017, 10382761
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 310
+	Hs
		473494 SHC1_HUMAN (1-583): 0: 529: 100.00		FCG3A_HUMAN (38-272): 3.31e-50: 168: 36.93
+	Hs
		629542 SHC1_HUMAN (1-583): 0: 529: 100.00		CD22_HUMAN (3-309): 3.38e-32: 127: 14.97
+	Mm
		770696 SHC1_MOUSE (1-583): 1.06e-180: 524: 94.51		CD22_MOUSE (3-295): 2.83e-26: 111: 13.64
+	Hs
		553340 SHC1_HUMAN (1-583): 0: 529: 100.00		FCGR1_HUMAN (5-282): 3.04e-23: 100: 12.29
+	Hs
		820703 SHC3_HUMAN (6-582): 8.25e-126: 384: 45.81		CEAM6_HUMAN (19-221): 1.98e-16: 80.6: 16.87
+	Hs
		593926 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		FCG2B_HUMAN (1-310): 1.01e-75: 236: 100.00
+	Hs
		593927 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		FCG2C_HUMAN (1-310): 2.62e-63: 204: 83.92
+	Hs
		553383 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		FCG2A_HUMAN (38-310): 3.48e-59: 193: 73.29
+	Mm
		558533 ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41		CNTN1_MOUSE (50-310): 4.81e-30: 121: 12.80
+	Hs
		629540 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		CD22_HUMAN (3-309): 3.38e-32: 127: 14.97
+	Hs
		593937 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		DCC_HUMAN (43-292): 9.74e-30: 121: 13.68
+	Hs
		553393 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		FCG2A_HUMAN (38-310): 3.48e-59: 193: 73.29
+	Hs
		473360 HCK_HUMAN (348-575): 6.63e-42: 160: 17.16		FCGR1_HUMAN (5-282): 3.04e-23: 100: 12.29
+	Mm
		686935 P85A_MOUSE (300-581): 1.94e-37: 149: 15.99		CD22_MOUSE (3-295): 2.83e-26: 111: 13.64
+	Mm
		999931 ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41		DCC_MOUSE (2-280): 1.53e-09: 61: 10.86
+	Mm
		465768 HCK_MOUSE (348-582): 9.22e-39: 151: 19.68		FCGR1_MOUSE (5-304): 2.16e-22: 97.9: 15.48
+	Hs
		222178 NCK2_HUMAN (363-579): 7.09e-45: 165: 18.83		FCRL2_HUMAN (52-217): 2.02e-13: 72.5: 20.65
+	Hs
		594010 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		MYLK_HUMAN (49-133): 1.13e-11: 67.5: 12.50
+	Hs
		699766 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		MYLK_HUMAN (49-133): 1.13e-11: 67.5: 12.50
+	Hs
		629547 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		CD22_HUMAN (3-309): 3.38e-32: 127: 14.97