HitPredict

Interactor 1: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0046330 - positive regulation of JNK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 310 Hs			1 304
+	Hs
		731817 FCG2C_HUMAN (1-310): 2.62e-63: 204: 83.92		CRK_HUMAN (1-304): 1.27e-69: 220: 100.00
+	Hs
		618995 FCG2B_HUMAN (1-310): 1.01e-75: 236: 100.00		PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48
+	Hs
		731809 FCG2B_HUMAN (1-310): 1.01e-75: 236: 100.00		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Hs
		618996 FCG2C_HUMAN (1-310): 2.62e-63: 204: 83.92		PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48
+	Hs
		731818 FCG2C_HUMAN (1-310): 2.62e-63: 204: 83.92		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Hs
		593926 FCG2B_HUMAN (1-310): 1.01e-75: 236: 100.00		NCK1_HUMAN (2-86): 7.33e-11: 64.1: 19.77
+	Hs
		553393 FCG2A_HUMAN (38-310): 3.48e-59: 193: 73.29		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Hs
		553345 FCGR1_HUMAN (5-282): 3.04e-23: 100: 12.29		CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42
+	Hs
		593927 FCG2C_HUMAN (1-310): 2.62e-63: 204: 83.92		NCK1_HUMAN (2-86): 7.33e-11: 64.1: 19.77
+	Hs
		618969 CD22_HUMAN (3-309): 3.38e-32: 127: 14.97		PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48
+	Hs
		629547 CD22_HUMAN (3-309): 3.38e-32: 127: 14.97		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Mm
		770698 CD22_MOUSE (3-295): 2.83e-26: 111: 13.64		PLCG1_MOUSE (2-302): 4.35e-30: 121: 15.53
+	Mm
		770697 CD22_MOUSE (3-295): 2.83e-26: 111: 13.64		GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51
+	Hs
		593937 DCC_HUMAN (43-292): 9.74e-30: 121: 13.68		NCK1_HUMAN (2-86): 7.33e-11: 64.1: 19.77
+	Hs
		913671 TITIN_HUMAN (4-301): 1.41e-09: 61.3: 9.17		VAV2_HUMAN (2-191): 3.45e-29: 119: 19.74
+	Hs
		987664 MYLK_HUMAN (49-133): 1.13e-11: 67.5: 12.50		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Hs
		987544 PGBM_HUMAN (111-287): 2e-11: 66.7: 9.95		GRB2_HUMAN (135-297): 1.31e-26: 106: 17.05
+	Ce
		145093 UNC89_CAEEL (121-303): 5.66e-10: 62.5: 14.00		VAV_CAEEL (13-194): 4.89e-22: 98.4: 23.94
+	Hs
		222178 FCRL2_HUMAN (52-217): 2.02e-13: 72.5: 20.65		NCK2_HUMAN (2-86): 2.66e-11: 65.6: 19.77
+	Hs
		594010 MYLK_HUMAN (49-133): 1.13e-11: 67.5: 12.50		NCK1_HUMAN (2-86): 7.33e-11: 64.1: 19.77