HitPredict

Interactor 1: RAD24 (P32641)
Checkpoint protein RAD24
Gene: RAD24

Interactor 2: RFC3 (P38629)
Replication factor C subunit 3 (Replication factor C3) (Activator 1 40 kDa subunit)
Gene: RFC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	11805837, 10660302, 10913172, 12604797, 15014082, 31182279, 35314830, 37968396
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~Rad17
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006281 - DNA repair GO:0031389 - Rad17 RFC-like complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 659 Sc			1 340
+	Sc
		744201 RAD24_YEAST (1-659): 0: 796: 100.00		RFC2_YEAST (1-329): 1.92e-74: 235: 32.26
+	Sc
		744200 RAD24_YEAST (1-659): 0: 796: 100.00		RFC4_YEAST (12-333): 5.43e-72: 227: 34.06
+	Sc
		744192 RAD24_YEAST (1-659): 0: 796: 100.00		RFC5_YEAST (14-332): 7.51e-56: 187: 21.97
+	Sc
		800943 RFC1_YEAST (21-552): 2.1e-75: 260: 15.43		RFC3_YEAST (1-340): 7.81e-95: 286: 100.00
+	Hs
		769933 RFC1_HUMAN (36-492): 2e-72: 255: 12.75		RFC5_HUMAN (8-338): 1.13e-85: 263: 49.40
+	Hs
		829123 CTF18_HUMAN (8-465): 4.36e-73: 255: 11.17		RFC5_HUMAN (8-338): 1.13e-85: 263: 49.40
+	Hs
		769669 RFC4_HUMAN (30-407): 3.59e-77: 252: 16.06		RFC5_HUMAN (8-338): 1.13e-85: 263: 49.40
+	Hs
		769667 RFC1_HUMAN (36-492): 2e-72: 255: 12.75		RFC4_HUMAN (3-332): 1.78e-82: 256: 34.62
+	Hs
		769754 CTF18_HUMAN (8-465): 4.36e-73: 255: 11.17		RFC4_HUMAN (3-332): 1.78e-82: 256: 34.62
+	Hs
		769815 RFC1_HUMAN (36-492): 2e-72: 255: 12.75		RFC2_HUMAN (13-329): 1.1e-78: 246: 34.59
+	Hs
		769884 CTF18_HUMAN (8-465): 4.36e-73: 255: 11.17		RFC2_HUMAN (13-329): 1.1e-78: 246: 34.59
+	Hs
		769666 RFC4_HUMAN (30-407): 3.59e-77: 252: 16.06		RFC2_HUMAN (13-329): 1.1e-78: 246: 34.59
+	Ce
		1166107 Q18841_CAEEL (49-493): 1.95e-80: 274: 15.24		Q18547_CAEEL (14-328): 7.97e-69: 221: 23.34
+	Sc
		800996 RFC1_YEAST (21-552): 2.1e-75: 260: 15.43		RFC2_YEAST (1-329): 1.92e-74: 235: 32.26
+	Sc
		800994 RFC1_YEAST (21-552): 2.1e-75: 260: 15.43		RFC4_YEAST (12-333): 5.43e-72: 227: 34.06
+	Ce
		916475 Q18841_CAEEL (49-493): 1.95e-80: 274: 15.24		RFC4_CAEEL (6-331): 6.71e-63: 204: 34.34
+	Hs
		769934 RFC1_HUMAN (36-492): 2e-72: 255: 12.75		RFC3_HUMAN (14-333): 3.89e-60: 198: 23.78
+	Hs
		829252 CTF18_HUMAN (8-465): 4.36e-73: 255: 11.17		RFC3_HUMAN (14-333): 3.89e-60: 198: 23.78
+	Hs
		769670 RFC4_HUMAN (30-407): 3.59e-77: 252: 16.06		RFC3_HUMAN (14-333): 3.89e-60: 198: 23.78
+	Sc
		796694 RFC1_YEAST (21-552): 2.1e-75: 260: 15.43		RFC5_YEAST (14-332): 7.51e-56: 187: 21.97