HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C12 (Q99456)
Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)
Gene: KRT12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 494
+	Hs
		437152 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C17_HUMAN (119-491): 6.03e-150: 436: 60.05
+	Hs
		385035 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C14_HUMAN (94-490): 1.31e-147: 432: 58.44
+	Hs
		437075 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C10_HUMAN (120-434): 4.88e-129: 388: 69.21
+	Hs
		437062 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C19_HUMAN (112-436): 8.6e-128: 379: 65.23
+	Hs
		437076 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C13_HUMAN (117-436): 5.29e-126: 376: 64.38
+	Hs
		437088 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C15_HUMAN (124-490): 4.65e-126: 376: 58.86
+	Hs
		49878 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		A1A4E9_HUMAN (117-436): 1.36e-125: 375: 64.06
+	Hs
		437064 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C16_HUMAN (121-436): 5.51e-125: 374: 67.09
+	Hs
		437109 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1C20_HUMAN (118-492): 1.26e-107: 328: 50.13
+	Hs
		300259 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KT33A_HUMAN (119-436): 1.89e-107: 327: 54.40
+	Hs
		227198 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KRT86_HUMAN (10-455): 2.89e-97: 303: 23.49
+	Hs
		341724 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C75_HUMAN (8-443): 3.65e-89: 284: 24.73
+	Hs
		437176 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C72_HUMAN (7-443): 1.52e-83: 269: 23.20
+	Hs
		300718 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KRT38_HUMAN (35-448): 4.81e-83: 266: 38.80
+	Hs
		300545 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		KRT36_HUMAN (33-494): 5.04e-81: 261: 43.31
+	Hs
		437172 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K1H2_HUMAN (40-440): 7.58e-80: 257: 44.03
+	Hs
		407237 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6B_HUMAN (91-443): 9.04e-76: 250: 26.27
+	Hs
		437077 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C5_HUMAN (91-443): 1.2e-75: 250: 27.40
+	Hs
		437121 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6C_HUMAN (91-443): 1.27e-75: 249: 26.84
+	Hs
		385216 K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33		K2C6A_HUMAN (91-443): 1.43e-74: 247: 26.84