HitPredict

Interactor 1: THB (P37242)
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Gene: Thrb

Interactor 2: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34474245
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 461 Mm			1 579
+	Hs
		395548 ESR1_HUMAN (16-460): 4.76e-106: 328: 19.40		SHC1_HUMAN (1-579): 4.12e-180: 522: 94.51
+	Hs
		533316 THB_HUMAN (1-461): 6.69e-147: 428: 96.53		SRC_HUMAN (334-570): 2.53e-44: 167: 16.87
+	Hs
		557079 RXRA_HUMAN (2-460): 1.92e-124: 371: 21.28		SRC_HUMAN (334-570): 2.53e-44: 167: 16.87
+	Mm
		686940 THB_MOUSE (1-461): 1.6e-148: 433: 100.00		P85A_MOUSE (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		533323 THB_HUMAN (1-461): 6.69e-147: 428: 96.53		P85A_HUMAN (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		520501 RARA_HUMAN (5-461): 6.01e-114: 344: 29.32		SRC_HUMAN (334-570): 2.53e-44: 167: 16.87
+	Hs
		395400 ESR1_HUMAN (16-460): 4.76e-106: 328: 19.40		SRC_HUMAN (334-570): 2.53e-44: 167: 16.87
+	Mm
		431322 ESR1_MOUSE (1-460): 6.1e-103: 321: 19.42		SRC_MOUSE (334-570): 3.12e-44: 166: 16.87
+	Rn
		439610 ESR1_RAT (16-460): 3.26e-103: 321: 19.61		SRC_RAT (334-570): 7.52e-43: 162: 16.40
+	Hs
		625764 RXRA_HUMAN (2-460): 1.92e-124: 371: 21.28		P85A_HUMAN (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		520515 RARA_HUMAN (5-461): 6.01e-114: 344: 29.32		P85A_HUMAN (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		987576 PPARA_HUMAN (71-461): 1.16e-115: 349: 27.16		GRB2_HUMAN (478-574): 1.34e-15: 77.9: 30.48
+	Hs
		533249 THA_HUMAN (88-430): 6.79e-108: 330: 78.72		P85A_HUMAN (478-575): 3.93e-19: 93.5: 24.51
+	Rn
		989508 THA_RAT (88-430): 5.63e-108: 330: 78.72		P85A_RAT (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		395537 ESR1_HUMAN (16-460): 4.76e-106: 328: 19.40		P85A_HUMAN (478-575): 3.93e-19: 93.5: 24.51
+	Hs
		136247 ESR1_HUMAN (16-460): 4.76e-106: 328: 19.40		P85B_HUMAN (478-575): 1.08e-18: 91.9: 23.53
+	Hs
		987877 NR1H4_HUMAN (56-460): 1.76e-109: 333: 29.18		GRB2_HUMAN (478-574): 1.34e-15: 77.9: 30.48
+	Hs
		343252 ERR2_HUMAN (7-460): 7.5e-107: 325: 22.47		GRB2_HUMAN (478-574): 1.34e-15: 77.9: 30.48
+	Hs
		557311 NR1I3_HUMAN (103-443): 1.11e-46: 166: 33.14		SRC_HUMAN (334-570): 2.53e-44: 167: 16.87