HitPredict

Interactor 1: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	28561026, 33961781, 35271311, 36931259, 12438239, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation, filter binding, coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006469 - negative regulation of protein kinase activity GO:0016020 - membrane GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1807 Hs			1 247
+	Hs
		835035 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		835048 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Mm
		905343 TSC2_MOUSE (1-1807): 0: 2653: 88.43		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Hs
		683209 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		835039 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646730 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683908 TSC2_HUMAN (1-1807): 0: 2708: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Mm
		1142069 TSC2_MOUSE (1-1807): 0: 2653: 88.43		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Hs
		909678 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904712 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982139 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		196427 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		196426 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		683443 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927166 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646999 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684116 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		196405 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		196402 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		196406 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16