HitPredict

Interactor 1: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	20011120, 26527279, 34079125, 36089195, 15616580
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1647 Hs			1 136
+	Hs
		846989 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		846925 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		847003 SMCA4_HUMAN (1-1647): 0: 1105: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		846743 SMCA2_HUMAN (1-1647): 0: 980: 71.69		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		828175 SMCA2_HUMAN (1-1647): 0: 980: 71.69		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Dm
		356069 BRM_DROME (211-1642): 0: 858: 53.26		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Hs
		229359 SMCA5_HUMAN (626-1631): 0: 835: 27.41		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		229363 SMCA5_HUMAN (626-1631): 0: 835: 27.41		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		935460 SMCA5_MOUSE (626-1631): 0: 833: 27.41		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Hs
		658647 SMCA1_HUMAN (639-1619): 0: 832: 28.82		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Mm
		952763 SMCA5_MOUSE (626-1631): 0: 833: 27.41		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		658651 SMCA1_HUMAN (639-1619): 0: 832: 28.82		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		952266 SMCA5_MOUSE (626-1631): 0: 833: 27.41		H32_MOUSE (1-136): 6.5e-61: 185: 99.27
+	Sp
		457191 SNF21_SCHPO (460-1587): 0: 806: 39.17		H31_SCHPO (1-136): 3.54e-59: 181: 91.91
+	Hs
		229341 SMCA5_HUMAN (626-1631): 0: 835: 27.41		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		658641 SMCA1_HUMAN (639-1619): 0: 832: 28.82		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Sc
		696239 STH1_YEAST (369-1559): 0: 789: 33.10		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		902117 ISW2_YEAST (565-1631): 0: 763: 25.02		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		603332 SNF2_YEAST (536-1569): 0: 757: 36.31		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		696197 STH1_YEAST (369-1559): 0: 789: 33.10		CENPA_YEAST (18-134): 2.12e-41: 138: 55.83