HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	19380743, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 676
+	Hs
		855955 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		292883 GRAP2_HUMAN (1-296): 8.89e-36: 133: 17.17		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		619136 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		599312 PLCG2_HUMAN (1-301): 3.43e-28: 116: 15.82		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		855612 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		73036 B1AT92_MOUSE (135-297): 1.16e-29: 113: 16.35		GAB2_MOUSE (3-676): 1.72e-174: 515: 90.95
+	Hs
		855866 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		1191823 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		Q3ZB59_MOUSE (3-676): 2.79e-174: 514: 91.10
+	Hs
		584536 VAV_HUMAN (11-189): 6.63e-47: 170: 28.21		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		1341655 Q8R5B8_MOUSE (2-114): 3.2e-43: 145: 65.49		GAB1_MOUSE (3-675): 1.11e-141: 431: 37.73
+	Hs
		292833 GRAP2_HUMAN (1-296): 8.89e-36: 133: 17.17		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		1106514 VAV3_HUMAN (11-189): 1.57e-33: 131: 26.15		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		619053 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		913647 VAV2_HUMAN (2-191): 3.45e-29: 119: 19.74		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		1223514 PLCG1_MOUSE (2-302): 4.35e-30: 121: 15.53		GAB1_MOUSE (3-675): 1.11e-141: 431: 37.73
+	Hs
		599288 PLCG2_HUMAN (1-301): 3.43e-28: 116: 15.82		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		1221262 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		GAB1_MOUSE (3-675): 1.11e-141: 431: 37.73
+	Hs
		855886 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		1234832 DNMBP_HUMAN (119-293): 5.73e-46: 168: 29.35		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		855941 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80