Interactor 1: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Interactor 2: OTUD3 (Q5T2D3)
OTU domain-containing protein 3 (EC 3.4.19.12)
Gene: OTUD3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 26280536, 33543443
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0050821 - protein stabilization
GO:0051898 - negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 403
Hs

1 398
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024