HitPredict

Interactor 1: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Interactor 2: ARP10 (Q9NZ32)
Actin-related protein 10 (Actin-related protein 11) (hARP11)
Gene: ACTR10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	34079125, 33961781, 12857853
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005829 - cytosol GO:0005869 - dynactin complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Hs			1 417
+	Hs
		785576 ACTY_HUMAN (1-376): 0: 728: 90.43		ARP10_HUMAN (1-417): 0: 565: 100.00
+	Hs
		891655 ACTZ_HUMAN (1-376): 0: 771: 100.00		ACTB_HUMAN (10-384): 1.71e-173: 491: 23.94
+	Hs
		897031 ACTZ_HUMAN (1-376): 0: 771: 100.00		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		897033 ACTZ_HUMAN (1-376): 0: 771: 100.00		ACTC_HUMAN (7-384): 4e-172: 487: 24.51
+	Hs
		897029 ACTZ_HUMAN (1-376): 0: 771: 100.00		ACTA_HUMAN (7-384): 4.62e-171: 485: 24.26
+	Hs
		785527 ACTY_HUMAN (1-376): 0: 728: 90.43		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		785529 ACTY_HUMAN (1-376): 0: 728: 90.43		ACTC_HUMAN (7-384): 4e-172: 487: 24.51
+	Dm
		361129 ACT4_DROME (11-376): 0: 612: 52.70		ACT2_DROME (8-384): 4.24e-173: 490: 24.57
+	Dm
		361164 ACT4_DROME (11-376): 0: 612: 52.70		ACT5_DROME (8-383): 2.8e-173: 490: 24.88
+	Dm
		361177 ACT4_DROME (11-376): 0: 612: 52.70		ACT3_DROME (8-383): 6.35e-173: 489: 25.12
+	Dm
		361179 ACT4_DROME (11-376): 0: 612: 52.70		ACT6_DROME (8-383): 4.85e-172: 487: 24.88
+	Ce
		501463 ACT2_CAEEL (7-376): 0: 581: 52.41		ACT2_CAEEL (8-384): 9.48e-174: 492: 24.32
+	Ce
		501464 ACT2_CAEEL (7-376): 0: 581: 52.41		ACT4_CAEEL (8-384): 8.59e-174: 492: 24.57
+	Ce
		483542 ACT2_CAEEL (7-376): 0: 581: 52.41		ACT3_CAEEL (8-384): 3.09e-173: 490: 24.32
+	Gg
		891646 ACTB_CHICK (7-376): 0: 580: 52.41		ACTB_CHICK (10-384): 1.71e-173: 491: 23.94
+	Hs
		891675 ACTG_HUMAN (7-376): 0: 580: 52.67		ACTB_HUMAN (10-384): 1.71e-173: 491: 23.94
+	Hs
		929815 ACTG_HUMAN (7-376): 0: 580: 52.67		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		929883 Q1KLZ0_HUMAN (7-376): 0: 580: 52.41		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		929816 ACTG_HUMAN (7-376): 0: 580: 52.67		ACTH_HUMAN (8-384): 2.65e-170: 483: 24.57
+	Dm
		800145 ACTZ_DROME (1-376): 0: 649: 79.26		Q9VWE8_DROME (1-394): 1.1e-92: 285: 40.25