HitPredict

Interactor 1: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15364934, 24362026
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 307 Hs			1 833
+	Hs
		994320 PP2AA_HUMAN (6-307): 0: 524: 65.89		M4K1_HUMAN (1-833): 0: 899: 100.00
+	Hs
		994288 PP2AA_HUMAN (6-307): 0: 524: 65.89		M4K3_HUMAN (7-820): 0: 852: 41.03
+	Hs
		692035 PP2AB_HUMAN (6-307): 0: 525: 65.23		MARK3_HUMAN (14-595): 1.54e-139: 432: 17.54
+	Hs
		977565 PP2AB_HUMAN (6-307): 0: 525: 65.23		MARK4_HUMAN (14-608): 7.83e-137: 425: 17.54
+	Hs
		977483 PP2AB_HUMAN (6-307): 0: 525: 65.23		KCC2B_HUMAN (13-532): 2.56e-133: 414: 19.71
+	Hs
		994210 PP2AA_HUMAN (6-307): 0: 524: 65.89		KCC2B_HUMAN (13-532): 2.56e-133: 414: 19.71
+	Mm
		728515 PP2AA_MOUSE (6-307): 0: 524: 65.89		AKT1_MOUSE (1-337): 6.25e-129: 396: 23.12
+	Hs
		728156 PP2AA_HUMAN (6-307): 0: 524: 65.89		AKT1_HUMAN (1-337): 8.08e-129: 395: 23.12
+	Hs
		728574 PP2AA_HUMAN (6-307): 0: 524: 65.89		AKT2_HUMAN (1-337): 1.15e-128: 395: 23.19
+	Hs
		994423 PP2AA_HUMAN (6-307): 0: 524: 65.89		AKT3_HUMAN (10-325): 6.93e-128: 393: 25.62
+	Hs
		138819 PP4C_HUMAN (1-307): 0: 537: 100.00		STK25_HUMAN (10-367): 1.35e-116: 362: 36.21
+	Ce
		113985 PP2A_CAEEL (2-307): 0: 524: 63.73		GCK1_CAEEL (12-448): 1.92e-118: 374: 31.77
+	Hs
		138821 PP2AB_HUMAN (6-307): 0: 525: 65.23		STK25_HUMAN (10-367): 1.35e-116: 362: 36.21
+	Hs
		138824 PP2AA_HUMAN (6-307): 0: 524: 65.89		STK25_HUMAN (10-367): 1.35e-116: 362: 36.21
+	Hs
		977602 PP2AB_HUMAN (6-307): 0: 525: 65.23		STK26_HUMAN (1-396): 2.74e-116: 361: 33.84
+	Hs
		977624 PP2AB_HUMAN (6-307): 0: 525: 65.23		STK24_HUMAN (9-295): 8.02e-116: 360: 42.36
+	Hs
		994404 PP2AA_HUMAN (6-307): 0: 524: 65.89		STK26_HUMAN (1-396): 2.74e-116: 361: 33.84
+	Hs
		994437 PP2AA_HUMAN (6-307): 0: 524: 65.89		STK24_HUMAN (9-295): 8.02e-116: 360: 42.36
+	Dm
		661952 PP2A_DROME (2-307): 0: 524: 64.05		HIPPO_DROME (13-289): 1.15e-109: 352: 43.17
+	Mm
		977628 PP2AB_MOUSE (6-307): 0: 525: 65.23		TNIK_MOUSE (11-296): 3.31e-64: 236: 42.57