HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2, UQ_con~zf_C2HC_14
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 232
+	Hs
		1389548 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		RN125_HUMAN (1-232): 5.67e-56: 180: 100.00
+	Hs
		906650 UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21		TRI26_HUMAN (22-228): 3.11e-46: 162: 14.88
+	Hs
		1490990 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		RN114_HUMAN (19-225): 1.16e-43: 148: 30.59
+	Hs
		623204 UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21		RO52_HUMAN (22-227): 8.35e-42: 149: 13.30
+	Hs
		1382356 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		RN166_HUMAN (1-224): 3.35e-42: 145: 30.42
+	Hs
		1439327 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI39_HUMAN (28-229): 1.05e-38: 141: 16.90
+	Hs
		1384952 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI43_HUMAN (24-229): 1.72e-36: 135: 15.35
+	Hs
		1420388 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI31_HUMAN (22-215): 2.91e-36: 133: 12.56
+	Hs
		1490991 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI17_HUMAN (22-226): 4.01e-35: 131: 15.32
+	Hs
		1420598 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRIM2_HUMAN (17-227): 8.94e-34: 130: 13.97
+	Hs
		1420579 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRIM5_HUMAN (24-229): 8.28e-34: 128: 16.28
+	Hs
		1357999 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		RN138_HUMAN (21-223): 2.32e-34: 125: 26.14
+	Hs
		1462531 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI35_HUMAN (24-230): 1.04e-32: 125: 12.96
+	Hs
		572291 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRI27_HUMAN (22-228): 2.61e-32: 124: 15.49
+	Hs
		906654 UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21		TRAF3_HUMAN (5-175): 6.69e-33: 126: 19.89
+	Hs
		571903 UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21		TRI27_HUMAN (22-228): 2.61e-32: 124: 15.49
+	Hs
		1490988 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		TRAF6_HUMAN (6-175): 1.76e-26: 108: 21.39
+	Hs
		587374 UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21		RAG1_HUMAN (26-140): 2.73e-25: 105: 27.73
+	Hs
		1348586 UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89		LNX1_HUMAN (28-142): 9.69e-24: 101: 24.17
+	Mm
		957271 UB2D1_MOUSE (4-149): 2.33e-80: 235: 45.21		RNF41_MOUSE (37-120): 3.52e-10: 60.5: 24.18