HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG22 (Q7Z5H3)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)
Gene: ARHGAP22

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 698
+	Hs
		962215 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		SRGP1_HUMAN (97-659): 3.82e-87: 297: 17.93
+	Hs
		962142 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG21_HUMAN (103-682): 1.04e-82: 288: 18.67
+	Mm
		1362439 RHOA_MOUSE (1-193): 2.21e-80: 238: 99.48		SRGP1_MOUSE (97-659): 1.42e-80: 279: 17.41
+	Hs
		699676 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		P85A_HUMAN (85-649): 6.79e-82: 276: 14.21
+	Mm
		686947 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		P85A_MOUSE (85-649): 3.54e-81: 274: 14.73
+	Hs
		74012 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MYO9A_HUMAN (49-665): 6.07e-77: 271: 15.29
+	Hs
		49960 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG10_HUMAN (8-566): 7.15e-78: 266: 17.83
+	Hs
		962589 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG20_HUMAN (61-683): 1.01e-75: 266: 16.26
+	Hs
		260706 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		OPHN1_HUMAN (8-568): 3.38e-77: 265: 16.30
+	Hs
		962580 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		GMIP_HUMAN (140-561): 2.26e-75: 263: 24.11
+	Hs
		962583 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG23_HUMAN (71-641): 3.27e-73: 260: 19.76
+	Hs
		962632 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG26_HUMAN (12-398): 3.51e-74: 257: 17.91
+	Hs
		962018 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MYO9B_HUMAN (88-552): 3.9e-69: 248: 17.38
+	Hs
		136355 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		P85B_HUMAN (154-649): 1.58e-70: 245: 15.58
+	Hs
		961987 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG01_HUMAN (150-356): 1.81e-69: 235: 29.95
+	Mm
		1204453 RHOA_MOUSE (1-193): 2.21e-80: 238: 99.48		RHG01_MOUSE (150-356): 1.21e-66: 227: 28.50
+	Hs
		962004 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG05_HUMAN (153-364): 9.09e-62: 226: 28.96
+	Mm
		988885 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		RHG01_MOUSE (150-356): 1.21e-66: 227: 28.50
+	Hs
		962001 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ABR_HUMAN (151-336): 3.05e-20: 97.8: 32.80
+	Hs
		539989 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		BCR_HUMAN (151-355): 2.98e-19: 95.1: 32.41