Protein: BACE1
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)

Gene: BACE1
Organism: Homo sapiens
Interactions: 51
UniProt ID: P56817

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004175 - endopeptidase activity
GO:0004190 - aspartic-type endopeptidase activity
GO:0005764 - lysosome
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

421807

A4
Amyloid-beta precursor protein

8

2

Small-scale

0.740

High

942360

GGA1
ADP-ribosylation factor-binding protein GGA1

5

5

Small-scale

0.733

High

942358

GGA3
ADP-ribosylation factor-binding protein GGA3

2

4

Small-scale

0.646

High

942359

GGA2
ADP-ribosylation factor-binding protein GGA2

2

5

Small-scale

0.646

High

942361

FBX2
F-box only protein 2

1

2

Small-scale

0.561

High

942362

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.537

High

942365

HYOU1
Hypoxia up-regulated protein 1

1

0

Small-scale

0.537

High

328889

RTN3
Reticulon-3

1

2

Small-scale

0.536

High

688543

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.536

High

942339

NKG2E
NKG2-E type II integral membrane protein

1

4

High-throughput

0.536

High

942357

RTN4
Reticulon-4

1

2

Small-scale

0.536

High

942356

TMX1
Thioredoxin-related transmembrane protein 1

2

2

Small-scale

0.521

High

889953

PSN1
Presenilin-1

1

0

Small-scale

0.519

High

458350

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

942347

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

0

Small-scale

0.513

High

942338

KCNC4
Voltage-gated potassium channel KCNC4

1

0

Small-scale

0.512

High

828189

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.501

High

942364

ITM2B
Integral membrane protein 2B

1

0

Small-scale

0.493

High

942349

NICA
Nicastrin

1

0

Small-scale

0.480

High

942363

SNX6
Sorting nexin-6

1

0

Small-scale

0.479

High

161012

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

Small-scale

0.479

High

907654

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

1

Small-scale

0.479

High

942341

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

Small-scale

0.479

High

942352

RANB9
Ran-binding protein 9

1

1

Small-scale

0.479

High

942353

SORT
Sortilin

1

1

Small-scale

0.479

High

336265

BRI3
Membrane protein BRI3

1

0

Small-scale

0.458

High

466567

TNR16
Tumor necrosis factor receptor superfamily member 16

1

0

Small-scale

0.458

High

942342

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

0

Small-scale

0.458

High

942351

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

452217

PDIA1
Protein disulfide-isomerase

1

3

Small-scale

0.445

High

534551

IAPP
Islet amyloid polypeptide

1

1

Small-scale

0.445

High

534844

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.445

High

656086

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

Small-scale

0.445

High

680296

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

Small-scale

0.445

High

697818

CALR
Calreticulin

1

4

Small-scale

0.445

High

698531

CALX
Calnexin

1

4

Small-scale

0.445

High

717420

PDIA3
Protein disulfide-isomerase A3

1

3

Small-scale

0.445

High

942337

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

Small-scale

0.445

High

942340

FLOT2
Flotillin-2

1

2

Small-scale

0.445

High

942345

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.445

High

424836

ADT2
ADP/ATP translocase 2

1

0

Small-scale

0.426

High

894516

GDIB
Rab GDP dissociation inhibitor beta

1

0

Small-scale

0.426

High

942343

IMB1
Importin subunit beta-1

1

0

Small-scale

0.426

High

942348

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

942355

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

Small-scale

0.426

High

942354

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

2

Small-scale

0.407

High

942344

SG1D4
Secretoglobin family 1D member 4

2

0

High-throughput

0.328

High

286534

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

942350

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

67154

TBB8B
Tubulin beta 8B

1

0

Small-scale

0.232

Low

942346

TPPC5
Trafficking protein particle complex subunit 5

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025