Protein: TBL2
Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein)

Gene: TBL2
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q9Y4P3

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0019901 - protein kinase binding
GO:0030968 - endoplasmic reticulum unfolded protein response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762173

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.691

High

397316

ESR1
Estrogen receptor

4

20

High-throughput

0.676

High

1227774

A16L1
Autophagy-related protein 16-1

2

19

High-throughput

0.659

High

1453368

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

3

14

Small-scale

0.640

High

193651

PDPK1
3-phosphoinositide-dependent protein kinase 1

4

5

High-throughput

0.638

High

1459639

SEC63
Translocation protein SEC63 homolog

2

7

High-throughput

0.621

High

303003

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.618

High

669294

PTAFR
Platelet-activating factor receptor

1

2

High-throughput

0.618

High

1416708

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.618

High

1429930

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

15

High-throughput

0.618

High

1490555

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

4

High-throughput

0.618

High

980603

H4
Histone H4

1

10

High-throughput

0.618

High

1126674

GRB7
Growth factor receptor-bound protein 7

1

8

Small-scale

0.618

High

1292828

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.618

High

1421041

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

9

High-throughput

0.618

High

243394

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

951544

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

1383201

LRC59
Leucine-rich repeat-containing protein 59

2

7

High-throughput

0.584

High

749826

CADH5
Cadherin-5

2

5

High-throughput

0.574

High

212511

SPIT2
Kunitz-type protease inhibitor 2

2

3

High-throughput

0.558

High

946609

EVA1C
Protein eva-1 homolog C

2

1

High-throughput

0.558

High

194408

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.553

High

316213

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.553

High

762073

GRK5
G protein-coupled receptor kinase 5

1

10

High-throughput

0.553

High

820782

CEAM6
Cell adhesion molecule CEACAM6

1

3

High-throughput

0.553

High

1137608

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.553

High

1142230

P2RY6
P2Y purinoceptor 6

1

5

High-throughput

0.553

High

1256253

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

1434331

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

1447497

ANLN
Anillin

1

5

High-throughput

0.553

High

208434

RRP8
Ribosomal RNA-processing protein 8

1

4

High-throughput

0.536

High

287208

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

15

High-throughput

0.536

High

329038

RTN3
Reticulon-3

1

4

High-throughput

0.536

High

429080

RLA0
Large ribosomal subunit protein uL10

1

8

High-throughput

0.536

High

686549

RL13
Large ribosomal subunit protein eL13

1

5

High-throughput

0.536

High

1085408

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

18

High-throughput

0.536

High

1288310

LYRIC
Protein LYRIC

1

3

High-throughput

0.536

High

1382259

CCD47
PAT complex subunit CCDC47

1

2

High-throughput

0.536

High

541782

FGFR1
Fibroblast growth factor receptor 1

2

11

High-throughput

0.521

High

182852

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.514

High

1235049

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.514

High

1126394

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1203851

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1381370

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1491448

TX264
Testis-expressed protein 264

1

0

High-throughput

0.513

High

191877

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.489

High

349614

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

607438

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

High-throughput

0.489

High

1005567

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

1

1

High-throughput

0.489

High

1043877

KCNC4
Voltage-gated potassium channel KCNC4

1

3

High-throughput

0.489

High

1102966

ITAD
Integrin alpha-D

1

3

High-throughput

0.489

High

1114748

CUL3
Cullin-3

1

20

High-throughput

0.489

High

1216424

FAXC
Failed axon connections homolog

1

1

High-throughput

0.489

High

1325959

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.489

High

1370498

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.489

High

1446832

GPC5C
G-protein coupled receptor family C group 5 member C

1

2

High-throughput

0.489

High

1450682

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

1462063

CLC4A
C-type lectin domain family 4 member A

1

3

High-throughput

0.489

High

1491445

PCDB3
Protocadherin beta-3

1

3

High-throughput

0.489

High

1491446

PCDGL
Protocadherin gamma-C4

1

3

High-throughput

0.489

High

1491447

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

220642

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.481

High

129594

MEN1
Menin

1

5

High-throughput

0.479

High

174161

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

178451

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

320182

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

374302

RASN
GTPase NRas

1

7

High-throughput

0.479

High

376141

RASK
GTPase KRas

1

6

High-throughput

0.479

High

386399

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

404570

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

418540

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

473219

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

581394

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

630113

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

694095

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

895177

EMD
Emerin

1

2

High-throughput

0.479

High

920399

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

932609

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

2

High-throughput

0.479

High

962672

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

1092285

NFX1
Transcriptional repressor NF-X1

1

7

High-throughput

0.479

High

1136424

EMC2
ER membrane protein complex subunit 2

1

12

High-throughput

0.479

High

1141104

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.479

High

1207466

HABP4
Intracellular hyaluronan-binding protein 4

1

4

High-throughput

0.479

High

1249363

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1290860

ZCH18
Zinc finger CCCH domain-containing protein 18

1

18

High-throughput

0.479

High

1334637

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.479

High

1335107

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1393871

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1396003

DNJC1
DnaJ homolog subfamily C member 1

1

16

High-throughput

0.479

High

1412737

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1431027

UN93B
Protein unc-93 homolog B1

1

2

High-throughput

0.479

High

1446954

RTN4
Reticulon-4

1

4

High-throughput

0.479

High

1490715

DJC16
DnaJ homolog subfamily C member 16

1

18

High-throughput

0.479

High

847759

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1117324

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1401265

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1404296

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

288831

NPM3
Nucleoplasmin-3

1

8

High-throughput

0.445

High

373607

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.445

High

430557

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

1363496

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.445

High

1365142

SL9A6
Sodium/hydrogen exchanger 6

1

1

High-throughput

0.445

High

1461386

AGO1
Protein argonaute-1

1

3

High-throughput

0.445

High

894266

MEOX2
Homeobox protein MOX-2

1

8

High-throughput

0.439

High

123458

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.437

High

132403

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.437

High

294582

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

412877

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.437

High

425689

ISG15
Ubiquitin-like protein ISG15

1

13

High-throughput

0.437

High

590127

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

696966

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

767384

MERL
Merlin

1

3

High-throughput

0.437

High

769607

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

831708

CCNF
Cyclin-F

1

8

High-throughput

0.437

High

832846

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

861341

MAP1B
Microtubule-associated protein 1B

1

17

High-throughput

0.437

High

872935

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.437

High

891375

GSK3A
Glycogen synthase kinase-3 alpha

1

9

High-throughput

0.437

High

939992

TPTE
Putative tyrosine-protein phosphatase TPTE

1

3

High-throughput

0.437

High

1067875

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.437

High

1126225

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1238863

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1277030

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1294298

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.437

High

1327294

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1329032

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.437

High

1333385

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

1339247

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.437

High

1352867

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.437

High

1368699

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.437

High

1383292

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.437

High

1390953

TSN17
Tetraspanin-17

1

2

High-throughput

0.437

High

1392509

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1397597

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.437

High

1404870

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.437

High

1433493

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.437

High

1446461

BRD7
Bromodomain-containing protein 7

1

19

High-throughput

0.437

High

1448186

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1452402

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

1453065

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.437

High

1458570

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.437

High

1459444

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.437

High

1461731

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.437

High

1461941

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.437

High

1186449

ASTRB
Protein Aster-B

1

0

High-throughput

0.426

High

1258717

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.426

High

1369328

EDA
Ectodysplasin-A

1

0

High-throughput

0.426

High

1391540

BSCL2
Seipin

1

0

High-throughput

0.426

High

1430470

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

653683

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

722670

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.407

High

923450

SC5A3
Sodium/myo-inositol cotransporter

1

1

High-throughput

0.407

High

944118

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.407

High

1032894

XPC
DNA repair protein complementing XP-C cells

1

1

High-throughput

0.407

High

1242975

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.407

High

1271289

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1288470

SO6A1
Solute carrier organic anion transporter family member 6A1

1

3

High-throughput

0.407

High

1290440

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

3

High-throughput

0.407

High

1313889

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

1323792

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.407

High

1326172

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.407

High

1420782

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.407

High

1446227

SO1B3
Solute carrier organic anion transporter family member 1B3

1

3

High-throughput

0.407

High

1454846

VGLU2
Vesicular glutamate transporter 2

1

1

High-throughput

0.407

High

596790

DPEP1
Dipeptidase 1

2

0

High-throughput

0.328

High

260995

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

275842

GLRA3
Glycine receptor subunit alpha-3

1

0

High-throughput

0.279

Low

388152

ACHA
Acetylcholine receptor subunit alpha

1

0

High-throughput

0.279

Low

1393228

TM169
Transmembrane protein 169

1

0

High-throughput

0.279

Low

1446728

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1155212

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

1163450

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1312630

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1338453

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1403835

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1450150

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1236392

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1242282

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1406441

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.232

Low

1431958

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.232

Low

1439135

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025