Protein: PLD6
Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog)

Gene: PLD6
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q8N2A8

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005794 - Golgi apparatus
GO:0007286 - spermatid development
GO:0008053 - mitochondrial fusion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1324147

SPP2B
Signal peptide peptidase-like 2B

2

2

High-throughput

0.628

High

1324166

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

1

High-throughput

0.628

High

1324200

TDRKH
Tudor and KH domain-containing protein

2

3

High-throughput

0.611

High

828401

PEX19
Peroxisomal biogenesis factor 19

3

1

High-throughput

0.609

High

535288

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.585

High

1043861

KCNC4
Voltage-gated potassium channel KCNC4

2

1

High-throughput

0.574

High

1324203

MTCH2
Mitochondrial carrier homolog 2

2

3

High-throughput

0.571

High

123142

DX39A
ATP-dependent RNA helicase DDX39A

1

1

High-throughput

0.553

High

733708

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

2

High-throughput

0.536

High

1124273

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.517

High

470314

NEP
Neprilysin

1

0

High-throughput

0.513

High

818876

ADCY8
Adenylate cyclase type 8

1

0

High-throughput

0.513

High

519635

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.489

High

723243

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

2

High-throughput

0.489

High

851167

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

2

High-throughput

0.489

High

1254060

LRC55
Leucine-rich repeat-containing protein 55

1

1

High-throughput

0.489

High

161881

IMPA2
Inositol monophosphatase 2

1

1

High-throughput

0.479

High

288978

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.479

High

602242

TMM11
Transmembrane protein 11, mitochondrial

1

1

High-throughput

0.479

High

716201

ERP29
Endoplasmic reticulum resident protein 29

1

2

High-throughput

0.479

High

766687

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

992853

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

1131314

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.479

High

1147637

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

1257973

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

1

High-throughput

0.479

High

1324141

ARL10
ADP-ribosylation factor-like protein 10

1

4

High-throughput

0.479

High

1324143

ATAD1
Outer mitochondrial transmembrane helix translocase

1

1

High-throughput

0.479

High

1324148

SPP
Signal peptide peptidase

1

2

High-throughput

0.479

High

1324156

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1324157

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1324162

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1324165

PHB2
Prohibitin-2

1

3

High-throughput

0.479

High

1324176

RAB34
Ras-related protein Rab-34

1

1

High-throughput

0.479

High

1324186

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1324187

DJC11
DnaJ homolog subfamily C member 11

1

3

High-throughput

0.479

High

1324202

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.479

High

166950

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

245496

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

277024

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.458

High

475995

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

749620

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

0

High-throughput

0.458

High

834341

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

895263

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.458

High

938590

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.458

High

1023364

AT2C1
Calcium-transporting ATPase type 2C member 1

1

0

High-throughput

0.458

High

1038906

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

0

High-throughput

0.458

High

1093381

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.458

High

1098724

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.458

High

1273954

DYM
Dymeclin

1

0

High-throughput

0.458

High

1312181

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

1324146

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.458

High

1324151

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1324158

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

Small-scale

0.458

High

1324164

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.458

High

1324179

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

1324182

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.458

High

1324185

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.458

High

1324188

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1324201

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.458

High

170865

CLGN
Calmegin

1

1

High-throughput

0.437

High

183167

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

1

High-throughput

0.437

High

280255

SC22B
Vesicle-trafficking protein SEC22b

1

2

High-throughput

0.437

High

698872

CALX
Calnexin

1

1

High-throughput

0.437

High

887691

PSB2
Proteasome subunit beta type-2

1

1

High-throughput

0.437

High

938754

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

2

High-throughput

0.437

High

941931

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

997423

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.437

High

1105510

OS9
Protein OS-9

1

1

High-throughput

0.437

High

1244351

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.437

High

1315937

CHSS2
Chondroitin sulfate synthase 2

1

1

High-throughput

0.437

High

1324160

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.437

High

1324167

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.437

High

1324173

TBB2B
Tubulin beta-2B chain

1

1

High-throughput

0.437

High

1324175

GTPB2
GTP-binding protein 2

1

1

High-throughput

0.437

High

1324184

AAAS
Aladin

1

1

High-throughput

0.437

High

1324191

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.437

High

1324193

SE1L1
Protein sel-1 homolog 1

1

1

High-throughput

0.437

High

1324181

AT131
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.407

High

730760

1433S
14-3-3 protein sigma

3

0

High-throughput

0.347

High

1324153

SL9A6
Sodium/hydrogen exchanger 6

3

0

High-throughput

0.345

High

1159078

C3AR
C3a anaphylatoxin chemotactic receptor

2

0

High-throughput

0.328

High

1248383

I27RA
Interleukin-27 receptor subunit alpha

2

0

High-throughput

0.328

High

1177163

MICB
MHC class I polypeptide-related sequence B

2

0

High-throughput

0.318

High

210462

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

270159

LRP3
Low-density lipoprotein receptor-related protein 3

1

0

High-throughput

0.279

Low

771790

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.279

Low

931264

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.279

Low

944828

PCBP3
Poly(rC)-binding protein 3

1

0

High-throughput

0.279

Low

1022423

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1106793

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.279

Low

1203721

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1324142

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1324149

MAGE2
Melanoma-associated antigen E2

1

0

High-throughput

0.279

Low

1324159

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.279

Low

1324163

JMJD8
JmjC domain-containing protein 8

1

0

High-throughput

0.279

Low

1324178

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1324197

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

136622

MANBA
Beta-mannosidase

1

0

High-throughput

0.249

Low

176687

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.249

Low

253770

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.249

Low

327114

NXPH4
Neurexophilin-4

1

0

High-throughput

0.249

Low

335628

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.249

Low

431854

ITB1
Integrin beta-1

1

0

High-throughput

0.249

Low

452325

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

469134

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.249

Low

518998

RO60
RNA-binding protein RO60

1

0

High-throughput

0.249

Low

608156

PYRG1
CTP synthase 1

1

0

High-throughput

0.249

Low

709070

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

0

High-throughput

0.249

Low

895599

SERPH
Serpin H1

1

0

High-throughput

0.249

Low

900914

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.249

Low

958307

ARP2
Actin-related protein 2

1

0

High-throughput

0.249

Low

1032502

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.249

Low

1054309

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.249

Low

1063811

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.249

Low

1085247

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

1127969

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.249

Low

1287497

PRUN1
Exopolyphosphatase PRUNE1

1

0

High-throughput

0.249

Low

1291953

LRP11
Low-density lipoprotein receptor-related protein 11

1

0

High-throughput

0.249

Low

1308155

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

1324139

ABD12
Lysophosphatidylserine lipase ABHD12

1

0

High-throughput

0.249

Low

1324140

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1324144

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.249

Low

1324145

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.249

Low

1324150

NEUFC
Neuferricin

1

0

High-throughput

0.249

Low

1324152

RGP1
RAB6A-GEF complex partner protein 2

1

0

High-throughput

0.249

Low

1324154

GCN1
Stalled ribosome sensor GCN1

1

0

High-throughput

0.249

Low

1324155

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.249

Low

1324161

CNDP2
Cytosolic non-specific dipeptidase

1

0

High-throughput

0.249

Low

1324168

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.249

Low

1324169

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

1324170

LRRC1
Leucine-rich repeat-containing protein 1

1

0

High-throughput

0.249

Low

1324171

FUCO2
Plasma alpha-L-fucosidase

1

0

High-throughput

0.249

Low

1324172

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.249

Low

1324174

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.249

Low

1324177

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.249

Low

1324180

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.249

Low

1324183

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.249

Low

1324189

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.249

Low

1324190

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low

1324192

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.249

Low

1324194

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.249

Low

1324195

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low

1324196

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1324198

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.249

Low

1324199

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.249

Low

1219514

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025