Protein: BIRC2
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)

Gene: BIRC2
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q13490

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001666 - response to hypoxia
GO:0001741 - XY body
GO:0001890 - placenta development
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1020642

TRAF2
TNF receptor-associated factor 2

38

20

Small-scale

0.995

High

1036263

BIRC2
Baculoviral IAP repeat-containing protein 2

22

18

Small-scale

0.990

High

1036359

DBLOH
Diablo IAP-binding mitochondrial protein

18

11

Small-scale

0.988

High

1036265

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

14

20

Small-scale

0.986

High

849322

UB2D1
Ubiquitin-conjugating enzyme E2 D1

14

20

Small-scale

0.983

High

1023650

TRAF1
TNF receptor-associated factor 1

13

14

Small-scale

0.982

High

876981

CASP9
Caspase-9

11

20

Small-scale

0.980

High

584398

TNR1A
Tumor necrosis factor receptor superfamily member 1A

9

12

Small-scale

0.971

High

1036316

BIRC7
Baculoviral IAP repeat-containing protein 7

7

17

Small-scale

0.966

High

919722

UB2D2
Ubiquitin-conjugating enzyme E2 D2

8

20

Small-scale

0.964

High

876945

CASP7
Caspase-7

6

20

Small-scale

0.949

High

475719

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

19

Small-scale

0.942

High

201791

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

5

20

Small-scale

0.939

High

957696

XIAP
E3 ubiquitin-protein ligase XIAP

5

16

Small-scale

0.925

High

788194

CASP3
Caspase-3

5

20

Small-scale

0.924

High

895788

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.914

High

1036296

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

4

1

High-throughput

0.904

High

1036271

CASP8
Caspase-8

4

20

Small-scale

0.895

High

177678

BIRC5
Baculoviral IAP repeat-containing protein 5

3

18

Small-scale

0.878

High

1036373

UB2J1
Ubiquitin-conjugating enzyme E2 J1

3

20

Small-scale

0.854

High

330252

BCL10
B-cell lymphoma/leukemia 10

3

5

Small-scale

0.847

High

846469

BLK
Tyrosine-protein kinase Blk

2

6

High-throughput

0.783

High

850740

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

7

High-throughput

0.783

High

788252

CASP2
Caspase-2

2

20

Small-scale

0.768

High

896435

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.767

High

1036277

UBE2S
Ubiquitin-conjugating enzyme E2 S

2

20

Small-scale

0.767

High

203928

HTRA2
Serine protease HTRA2, mitochondrial

7

15

Small-scale

0.749

High

352608

TNFA
Tumor necrosis factor

9

6

Small-scale

0.749

High

1036274

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

2

0

Small-scale

0.748

High

1036383

NEMO
NF-kappa-B essential modulator

6

11

Small-scale

0.733

High

1036326

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

2

High-throughput

0.704

High

1036307

TANK
TRAF family member-associated NF-kappa-B activator

4

2

Small-scale

0.704

High

1036313

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1036369

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.698

High

1024669

TRAF3
TNF receptor-associated factor 3

4

20

Small-scale

0.697

High

599658

TNAP3
Tumor necrosis factor alpha-induced protein 3

4

5

Small-scale

0.694

High

738663

TNR3
Tumor necrosis factor receptor superfamily member 3

4

12

Small-scale

0.694

High

1036322

RNF31
E3 ubiquitin-protein ligase RNF31

4

14

Small-scale

0.694

High

961381

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

14

Small-scale

0.691

High

1036275

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.691

High

963610

E2F1
Transcription factor E2F1

3

7

Small-scale

0.681

High

925256

RAC1
Ras-related C3 botulinum toxin substrate 1

3

12

Small-scale

0.681

High

1036319

GCC1
GRIP and coiled-coil domain-containing protein 1

3

6

High-throughput

0.675

High

1036357

EXOS5
Exosome complex component RRP46

3

2

High-throughput

0.675

High

260137

VPS4B
Vacuolar protein sorting-associated protein 4B

3

6

High-throughput

0.667

High

636484

DNJB2
DnaJ homolog subfamily B member 2

3

4

High-throughput

0.667

High

645799

CD27
CD27 antigen

3

12

High-throughput

0.667

High

670943

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

10

High-throughput

0.667

High

1036371

CLC11
C-type lectin domain family 11 member A

3

2

High-throughput

0.667

High

932513

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.665

High

591325

TNR1B
Tumor necrosis factor receptor superfamily member 1B

3

12

Small-scale

0.656

High

1036331

M3K14
Mitogen-activated protein kinase kinase kinase 14

3

20

Small-scale

0.650

High

1036379

TRAF6
TNF receptor-associated factor 6

3

20

Small-scale

0.650

High

1033104

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

Small-scale

0.647

High

1036358

BIRC6
Baculoviral IAP repeat-containing protein 6

1

19

Small-scale

0.647

High

538221

ENPL
Endoplasmin

2

8

Small-scale

0.646

High

639581

TNR5
Tumor necrosis factor receptor superfamily member 5

3

12

Small-scale

0.640

High

1036341

TSG10
Testis-specific gene 10 protein

2

7

High-throughput

0.640

High

1036374

BOLA1
BolA-like protein 1

4

6

High-throughput

0.637

High

1036375

FBX7
F-box only protein 7

3

0

Small-scale

0.632

High

893977

CDC42
Cell division control protein 42 homolog

2

12

Small-scale

0.629

High

257264

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

3

High-throughput

0.628

High

580425

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

2

2

High-throughput

0.628

High

1036281

DCA12
DDB1- and CUL4-associated factor 12

2

2

High-throughput

0.628

High

1036335

LPIN3
Phosphatidate phosphatase LPIN3

2

2

High-throughput

0.628

High

1036368

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

927749

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

20

Small-scale

0.621

High

1036304

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

4

Small-scale

0.621

High

159056

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.618

High

227371

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

338383

EGFR
Epidermal growth factor receptor

1

12

Small-scale

0.618

High

1035695

BIRC3
Baculoviral IAP repeat-containing protein 3

1

16

Small-scale

0.618

High

1036308

CASPA
Caspase-10

1

20

Small-scale

0.618

High

1036352

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

9

Small-scale

0.618

High

1036367

UBQL2
Ubiquilin-2

1

7

High-throughput

0.618

High

639740

IKBA
NF-kappa-B inhibitor alpha

2

20

High-throughput

0.611

High

1036337

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

15

High-throughput

0.611

High

232150

KDM1A
Lysine-specific histone demethylase 1A

2

5

High-throughput

0.606

High

777853

RFC5
Replication factor C subunit 5

2

6

High-throughput

0.606

High

987410

MTG8
Protein CBFA2T1

2

2

High-throughput

0.606

High

1036301

LNX1
E3 ubiquitin-protein ligase LNX

2

7

High-throughput

0.606

High

1036363

NXF1
Nuclear RNA export factor 1

2

1

High-throughput

0.606

High

570256

NEUM
Neuromodulin

2

0

High-throughput

0.602

High

1036284

ZFAN6
AN1-type zinc finger protein 6

2

0

High-throughput

0.602

High

1036355

TMM9B
Transmembrane protein 9B

2

0

High-throughput

0.602

High

983426

MAD1
Max dimerization protein 1

1

6

Small-scale

0.598

High

1036323

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.597

High

1036381

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

20

Small-scale

0.589

High

1036300

TNIP2
TNFAIP3-interacting protein 2

2

0

High-throughput

0.585

High

1036330

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.578

High

416981

IF4E
Eukaryotic translation initiation factor 4E

1

3

Small-scale

0.578

High

1036292

PACS2
Phosphofurin acidic cluster sorting protein 2

1

1

Small-scale

0.578

High

1036298

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

Small-scale

0.578

High

1036327

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

3

Small-scale

0.578

High

1036348

Q9H4D1
Protein kinase

1

19

Small-scale

0.578

High

259499

LRRN2
Leucine-rich repeat neuronal protein 2

2

2

High-throughput

0.574

High

341162

C1R
Complement C1r subcomponent

2

4

High-throughput

0.574

High

885206

ISK7
Serine protease inhibitor Kazal-type 7

2

1

High-throughput

0.574

High

1036283

GP107
Protein GPR107

2

1

High-throughput

0.574

High

1036289

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

1036344

CSTFT
Cleavage stimulation factor subunit 2 tau variant

2

2

High-throughput

0.574

High

1036370

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

Small-scale

0.573

High

535387

GFAP
Glial fibrillary acidic protein

1

4

High-throughput

0.573

High

979291

UBXN1
UBX domain-containing protein 1

2

5

Small-scale

0.571

High

545849

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

7

Small-scale

0.561

High

874503

XPO2
Exportin-2

1

8

Small-scale

0.561

High

1036267

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

15

Small-scale

0.561

High

1036310

GLMN
Glomulin

1

2

Small-scale

0.561

High

1036317

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

0

Small-scale

0.559

High

714964

PROF2
Profilin-2

1

2

Small-scale

0.552

High

881165

CTBP2
C-terminal-binding protein 2

1

8

Small-scale

0.552

High

1036318

EAF2
ELL-associated factor 2

1

0

High-throughput

0.549

High

542309

PLAK
Junction plakoglobin

1

8

High-throughput

0.541

High

796275

MAGAB
Melanoma-associated antigen 11

1

10

High-throughput

0.541

High

1036294

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

7

High-throughput

0.541

High

1036340

TRI34
E3 ubiquitin-protein ligase TRIM34

1

3

High-throughput

0.541

High

1036362

RN181
E3 ubiquitin-protein ligase RNF181

1

5

High-throughput

0.541

High

204492

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

2

High-throughput

0.536

High

254081

WDR1
WD repeat-containing protein 1

1

6

Small-scale

0.536

High

262447

TULP3
Tubby-related protein 3

1

2

High-throughput

0.536

High

299366

UBXN7
UBX domain-containing protein 7

1

4

High-throughput

0.536

High

304152

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

Small-scale

0.536

High

355202

HBE
Hemoglobin subunit epsilon

1

1

High-throughput

0.536

High

443184

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.536

High

607066

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

4

Small-scale

0.536

High

621780

PRTN3
Myeloblastin

1

6

High-throughput

0.536

High

668653

PML
Protein PML

1

9

High-throughput

0.536

High

682795

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

13

High-throughput

0.536

High

892794

IF4A1
Eukaryotic initiation factor 4A-I

1

9

High-throughput

0.536

High

902905

DCAF7
DDB1- and CUL4-associated factor 7

1

8

Small-scale

0.536

High

972732

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

1

High-throughput

0.536

High

1036272

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.536

High

1036279

KR132
Keratin-associated protein 13-2

1

1

High-throughput

0.536

High

1036280

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

Small-scale

0.536

High

1036282

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.536

High

1036286

ULK3
Serine/threonine-protein kinase ULK3

1

10

High-throughput

0.536

High

1036291

TAXB1
Tax1-binding protein 1

1

10

High-throughput

0.536

High

1036293

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

2

High-throughput

0.536

High

1036295

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

6

High-throughput

0.536

High

1036311

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

14

Small-scale

0.536

High

1036312

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

15

Small-scale

0.536

High

1036314

ARRD3
Arrestin domain-containing protein 3

1

6

High-throughput

0.536

High

1036321

OPTN
Optineurin

1

17

High-throughput

0.536

High

1036329

RBM14
RNA-binding protein 14

1

5

High-throughput

0.536

High

1036342

TOLIP
Toll-interacting protein

1

1

High-throughput

0.536

High

1036346

E41LB
Band 4.1-like protein 4B

1

6

High-throughput

0.536

High

1036351

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

3

High-throughput

0.536

High

1036377

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

18

Small-scale

0.536

High

1036380

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.536

High

327932

FTCD
Formimidoyltransferase-cyclodeaminase

1

0

High-throughput

0.518

High

207235

TNF14
Tumor necrosis factor ligand superfamily member 14

1

6

Small-scale

0.515

High

883506

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

Small-scale

0.515

High

1036285

XAF1
XIAP-associated factor 1

1

4

Small-scale

0.515

High

1036288

MAVS
Mitochondrial antiviral-signaling protein

1

10

Small-scale

0.515

High

1036315

SH3K1
SH3 domain-containing kinase-binding protein 1

1

6

Small-scale

0.515

High

206562

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

Small-scale

0.513

High

1036302

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.513

High

1036320

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.513

High

1036354

TNR12
Tumor necrosis factor receptor superfamily member 12A

1

0

Small-scale

0.513

High

1036378

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.513

High

1036353

TUFT1
Tuftelin

1

1

High-throughput

0.508

High

374184

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

Small-scale

0.501

High

900447

RHOA
Transforming protein RhoA

1

12

Small-scale

0.501

High

1036333

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

13

Small-scale

0.501

High

1036372

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

10

Small-scale

0.501

High

1036382

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

5

Small-scale

0.501

High

448999

GROA
Growth-regulated alpha protein

1

4

High-throughput

0.489

High

587793

CXCL3
C-X-C motif chemokine 3

1

4

High-throughput

0.489

High

1036270

PDIA5
Protein disulfide-isomerase A5

1

7

High-throughput

0.489

High

1036278

LRIT3
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

1

4

High-throughput

0.489

High

1036287

WDR82
WD repeat-containing protein 82

1

5

Small-scale

0.489

High

1036309

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

3

High-throughput

0.489

High

1036328

FIMP
Fertilization-influencing membrane protein

1

1

High-throughput

0.489

High

1036334

TS101
Tumor susceptibility gene 101 protein

1

3

Small-scale

0.481

High

1036347

BOLA2
BolA-like protein 2

1

6

High-throughput

0.481

High

179936

TLR3
Toll-like receptor 3

1

4

Small-scale

0.479

High

262265

ULK1
Serine/threonine-protein kinase ULK1

1

9

Small-scale

0.479

High

301386

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

20

Small-scale

0.479

High

319185

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.479

High

321893

RIGI
Antiviral innate immune response receptor RIG-I

1

14

Small-scale

0.479

High

324802

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

7

Small-scale

0.479

High

325716

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

590179

CCNA2
Cyclin-A2

1

4

Small-scale

0.479

High

617295

SP100
Nuclear autoantigen Sp-100

1

4

High-throughput

0.479

High

624586

CCNE1
G1/S-specific cyclin-E1

1

5

Small-scale

0.479

High

669885

CD40L
CD40 ligand

1

6

Small-scale

0.479

High

718828

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

835730

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.479

High

837009

MRE11
Double-strand break repair protein MRE11

1

3

Small-scale

0.479

High

868171

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

994150

DHX9
ATP-dependent RNA helicase A

1

11

Small-scale

0.479

High

1019481

ILF2
Interleukin enhancer-binding factor 2

1

5

Small-scale

0.479

High

1019723

ILF3
Interleukin enhancer-binding factor 3

1

9

Small-scale

0.479

High

1023269

TRI32
E3 ubiquitin-protein ligase TRIM32

1

12

Small-scale

0.479

High

1036264

SQSTM
Sequestosome-1

1

12

Small-scale

0.479

High

1036266

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1036268

NUCG
Endonuclease G, mitochondrial

1

2

Small-scale

0.479

High

1036269

BECN1
Beclin-1

1

2

Small-scale

0.479

High

1036332

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

18

Small-scale

0.479

High

1036336

TRI56
E3 ubiquitin-protein ligase TRIM56

1

15

Small-scale

0.479

High

1036350

EGLN3
Prolyl hydroxylase EGLN3

1

4

Small-scale

0.479

High

1036356

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1036361

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

8

Small-scale

0.479

High

1036364

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1036365

DMBT1
Deleted in malignant brain tumors 1 protein

1

2

Small-scale

0.479

High

1036366

TBK1
Serine/threonine-protein kinase TBK1

1

16

High-throughput

0.479

High

762

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

2

High-throughput

0.470

High

1036305

JPH3
Junctophilin-3

1

2

High-throughput

0.470

High

1036325

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

1

High-throughput

0.464

High

1026259

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.458

High

1036276

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.458

High

1036338

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1036345

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

352415

TNFB
Lymphotoxin-alpha

1

6

Small-scale

0.445

High

1036343

SHRPN
Sharpin

1

3

Small-scale

0.445

High

1036273

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

Small-scale

0.437

High

445942

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

4

0

High-throughput

0.370

High

1036360

TA2R7
Taste receptor type 2 member 7

3

0

High-throughput

0.347

High

1036290

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.328

High

1036297

CCYL1
Cyclin-Y-like protein 1

2

0

High-throughput

0.328

High

1036349

CS044
Uncharacterized protein C19orf44

2

0

High-throughput

0.328

High

1036376

TCAF1
TRPM8 channel-associated factor 1

2

0

High-throughput

0.316

High

87309

UMAD1
UBAP1-MVB12-associated

1

0

High-throughput

0.279

Low

653092

CD82
CD82 antigen

1

0

High-throughput

0.279

Low

856601

EFNA5
Ephrin-A5

1

0

High-throughput

0.279

Low

1012157

SYCN
Syncollin

1

0

High-throughput

0.279

Low

1036299

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.279

Low

1036303

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.279

Low

1036324

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

1036339

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.279

Low

1036306

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024