Protein: NPRL3
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)

Gene: NPRL3
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q12980

Gene Ontology (top 5):
GO:0003281 - ventricular septum development
GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0010508 - positive regulation of autophagy
GO:0032007 - negative regulation of TOR signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1021873

NPRL2
GATOR1 complex protein NPRL2

7

2

Small-scale

0.963

High

254980

DEPD5
GATOR1 complex protein DEPDC5

6

1

Small-scale

0.735

High

1021881

WDR24
GATOR2 complex protein WDR24

5

4

Small-scale

0.718

High

1021869

RRAGA
Ras-related GTP-binding protein A

3

2

Small-scale

0.640

High

885122

SESN2
Sestrin-2

2

1

Small-scale

0.634

High

1021867

WDR59
GATOR2 complex protein WDR59

3

5

Small-scale

0.633

High

992659

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

1021859

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

1021864

SZT2
KICSTOR complex protein SZT2

2

0

Small-scale

0.585

High

1021899

KPTN
KICSTOR complex protein kaptin

2

0

Small-scale

0.585

High

885144

SESN3
Sestrin-3

1

1

Small-scale

0.550

High

953148

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.513

High

1021876

ITFG2
KICSTOR complex protein ITFG2

1

0

High-throughput

0.513

High

1021890

RRAGC
Ras-related GTP-binding protein C

1

2

Small-scale

0.479

High

1021891

RRAGD
Ras-related GTP-binding protein D

1

2

Small-scale

0.479

High

1021893

MIOS
GATOR2 complex protein MIOS

1

2

Small-scale

0.479

High

506994

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

787154

RHG25
Rho GTPase-activating protein 25

1

0

High-throughput

0.458

High

1021857

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.439

High

1021875

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.439

High

175865

P73
Tumor protein p73

1

3

High-throughput

0.437

High

227311

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.437

High

386636

P53
Cellular tumor antigen p53

1

3

High-throughput

0.437

High

1021888

P63
Tumor protein 63

1

3

High-throughput

0.437

High

282214

SEGN
Secretagogin

3

0

High-throughput

0.347

High

1021868

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1021879

ZN414
Zinc finger protein 414

2

0

High-throughput

0.318

High

1021887

CHIA
Acidic mammalian chitinase

2

0

High-throughput

0.318

High

62139

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.279

Low

149854

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.279

Low

234815

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

276236

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

277238

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

277299

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

311694

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.279

Low

413089

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.279

Low

428170

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

568978

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.279

Low

729074

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.279

Low

734924

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.279

Low

871548

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.279

Low

971083

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

975422

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.279

Low

1021856

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1021858

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1021860

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1021862

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1021863

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.279

Low

1021865

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1021866

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.279

Low

1021870

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

1021871

KLH34
Kelch-like protein 34

1

0

High-throughput

0.279

Low

1021872

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1021874

ASB13
Ankyrin repeat and SOCS box protein 13

1

0

High-throughput

0.279

Low

1021877

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

1021880

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

1021882

METH
Methionine synthase

1

0

High-throughput

0.279

Low

1021883

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1021884

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

1021885

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.279

Low

1021886

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.279

Low

1021889

PIGU
Phosphatidylinositol glycan anchor biosynthesis class U protein

1

0

High-throughput

0.279

Low

1021892

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

1021894

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.279

Low

1021896

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.279

Low

1021898

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.279

Low

1021878

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.269

Low

475686

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

487384

ANDR
Androgen receptor

1

0

High-throughput

0.249

Low

1021895

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.249

Low

1021897

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.249

Low

1021861

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024