Protein: MED12
Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Mediator complex subunit Kohtalo) (dTRAP230)

Gene: MED12, kto
Organism: Drosophila melanogaster
Interactions: 59
UniProt ID: Q9VW47

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005700 - polytene chromosome
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1269638

MED13
Mediator of RNA polymerase II transcription subunit 13

6

5

Small-scale

0.935

High

1485962

CDK8
Cyclin-dependent kinase 8

3

11

Small-scale

0.643

High

668183

CCNC
Cyclin-C

2

11

Small-scale

0.631

High

873639

PP1B
Serine/threonine-protein phosphatase beta isoform

2

9

High-throughput

0.584

High

1428003

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

High-throughput

0.575

High

1487590

MED14
Mediator of RNA polymerase II transcription subunit 14

2

20

High-throughput

0.571

High

1302900

MED31
Mediator of RNA polymerase II transcription subunit 31

2

2

Small-scale

0.552

High

1345517

Q8T0U6
Serine/threonine-protein phosphatase

2

8

High-throughput

0.504

High

1467125

PYGO
Protein pygopus

1

18

Small-scale

0.501

High

1379160

HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

High-throughput

0.494

High

624424

CI
Transcriptional activator cubitus interruptus

1

5

Small-scale

0.479

High

628544

USP
Protein ultraspiracle

1

20

Small-scale

0.479

High

701312

SUH
Suppressor of hairless protein

1

4

Small-scale

0.479

High

756507

ECR
Ecdysone receptor

1

20

Small-scale

0.479

High

58515

MED8
Mediator of RNA polymerase II transcription subunit 8

1

2

High-throughput

0.445

High

197491

O18353
CHIP

1

1

High-throughput

0.445

High

263215

TENM
Teneurin-m

1

2

High-throughput

0.445

High

674060

BRM
ATP-dependent helicase brm

1

19

High-throughput

0.445

High

1069941

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

3

High-throughput

0.445

High

1171924

Q24090
GH08712p

1

5

High-throughput

0.445

High

1175398

NETB
Netrin-B

1

7

High-throughput

0.445

High

1267073

MED29
Mediator of RNA polymerase II transcription subunit 29

1

2

High-throughput

0.445

High

1303633

OSA
Trithorax group protein osa

1

16

High-throughput

0.445

High

1321580

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.445

High

1346035

ENA
Protein enabled

1

16

High-throughput

0.445

High

1377805

EBI
F-box-like/WD repeat-containing protein ebi

1

13

High-throughput

0.445

High

1378344

Q95TT5
LD24616p

1

12

High-throughput

0.445

High

1428112

MED7
Mediator of RNA polymerase II transcription subunit 7

1

2

High-throughput

0.445

High

1471842

MED25
Mediator of RNA polymerase II transcription subunit 25

1

19

High-throughput

0.445

High

1472590

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

18

High-throughput

0.445

High

1472616

MED17
Mediator of RNA polymerase II transcription subunit 17

1

2

High-throughput

0.445

High

1473446

Q9VF03
Brahma associated protein 155 kDa

1

18

High-throughput

0.445

High

1482743

MED27
Mediator of RNA polymerase II transcription subunit 27

1

2

High-throughput

0.445

High

1485343

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.445

High

1485575

MED24
Mediator of RNA polymerase II transcription subunit 24

1

2

High-throughput

0.445

High

1487350

MED19
Mediator of RNA polymerase II transcription subunit 19

1

2

High-throughput

0.445

High

1487434

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.445

High

1487587

BAP60
Brahma-associated protein of 60 kDa

1

9

High-throughput

0.445

High

1487589

MED30
Mediator of RNA polymerase II transcription subunit 30

1

2

High-throughput

0.445

High

1487591

MED23
Mediator of RNA polymerase II transcription subunit 23

1

7

High-throughput

0.445

High

1487592

MED16
Mediator of RNA polymerase II transcription subunit 16

1

2

High-throughput

0.445

High

1487593

Q9W3G1
Uncharacterized protein, isoform A

1

18

High-throughput

0.445

High

1487594

MED18
Mediator of RNA polymerase II transcription subunit 18

1

2

High-throughput

0.445

High

1487595

MED15
Mediator of RNA polymerase II transcription subunit 15

1

19

High-throughput

0.445

High

84731

UNR
RNA-binding protein Unr

1

1

High-throughput

0.407

High

84989

B7Z126
non-specific serine/threonine protein kinase

1

8

High-throughput

0.407

High

119324

M9NFI9
Neurabin-1

1

7

High-throughput

0.407

High

609156

CRN
Protein crooked neck

1

6

High-throughput

0.407

High

900682

DSH
Segment polarity protein dishevelled

1

1

High-throughput

0.407

High

1321527

ENC
Protein encore

1

13

High-throughput

0.407

High

1346448

MESD
LDLR chaperone boca

1

3

High-throughput

0.407

High

1378946

Q960F7
SD03629p

1

4

High-throughput

0.407

High

1409402

Q9BIW6
Brahma-associated protein 111kD

1

18

High-throughput

0.407

High

1440707

LAR4
La-related protein Larp4B

1

5

High-throughput

0.407

High

1485610

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

20

High-throughput

0.407

High

1486602

Q9VUB7
PAX-interacting protein 1

1

20

High-throughput

0.407

High

1487588

Q9W0L7
ubiquitinyl hydrolase 1

1

2

High-throughput

0.407

High

1480273

Q9VL29
GEO11246p1

1

0

High-throughput

0.232

Low

1487586

Q9VXZ3
Ben, isoform C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025