Protein: TANK
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)

Gene: TANK
Organism: Homo sapiens
Interactions: 240
UniProt ID: Q92844

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0007165 - signal transduction
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1369508

TBK1
Serine/threonine-protein kinase TBK1

26

5

Small-scale

0.767

High

1090831

TRAF2
TNF receptor-associated factor 2

13

9

Small-scale

0.762

High

1094943

TRAF3
TNF receptor-associated factor 3

12

10

Small-scale

0.760

High

1369518

NEMO
NF-kappa-B essential modulator

11

1

Small-scale

0.758

High

1122533

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

8

5

Small-scale

0.753

High

1093899

TRAF1
TNF receptor-associated factor 1

6

8

Small-scale

0.733

High

1369458

TANK
TRAF family member-associated NF-kappa-B activator

5

1

Small-scale

0.708

High

1107440

BIRC2
Baculoviral IAP repeat-containing protein 2

4

2

Small-scale

0.704

High

920154

PLK1
Serine/threonine-protein kinase PLK1

4

0

Small-scale

0.679

High

136713

TRAF5
TNF receptor-associated factor 5

3

9

Small-scale

0.664

High

1129166

IRF3
Interferon regulatory factor 3

3

2

Small-scale

0.640

High

298269

BODG
Gamma-butyrobetaine dioxygenase

3

0

High-throughput

0.638

High

1339637

TNIP2
TNFAIP3-interacting protein 2

3

0

High-throughput

0.638

High

1369515

TRAF6
TNF receptor-associated factor 6

2

10

Small-scale

0.624

High

177920

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

5

Small-scale

0.621

High

1203982

ZC12A
Endoribonuclease ZC3H12A

2

0

Small-scale

0.613

High

167943

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

5

Small-scale

0.611

High

272364

OBSL1
Obscurin-like protein 1

2

1

High-throughput

0.611

High

1096915

FADD
FAS-associated death domain protein

2

4

Small-scale

0.611

High

1307139

TCAM1
TIR domain-containing adapter molecule 1

2

1

Small-scale

0.611

High

378153

TNFA
Tumor necrosis factor

3

0

Small-scale

0.606

High

1369472

CEP63
Centrosomal protein of 63 kDa

2

0

High-throughput

0.604

High

843829

HD
Huntingtin

2

1

High-throughput

0.596

High

355094

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

1

High-throughput

0.586

High

683302

TNR5
Tumor necrosis factor receptor superfamily member 5

2

1

Small-scale

0.563

High

1364954

TSC1
Hamartin

1

0

High-throughput

0.558

High

1369459

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.552

High

1115576

ASPP2
Apoptosis-stimulating of p53 protein 2

1

0

High-throughput

0.549

High

1369499

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.537

High

181647

CETN3
Centrin-3

1

1

High-throughput

0.536

High

317296

STK10
Serine/threonine-protein kinase 10

1

1

High-throughput

0.536

High

618088

K1C15
Keratin, type I cytoskeletal 15

1

2

High-throughput

0.536

High

639279

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

High-throughput

0.536

High

689992

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

1

High-throughput

0.536

High

787689

SPB5
Serpin B5

1

1

High-throughput

0.536

High

821171

TXLNA
Alpha-taxilin

1

2

High-throughput

0.536

High

874833

SPB4
Serpin B4

1

1

High-throughput

0.536

High

876715

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.536

High

876957

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.536

High

877191

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

891269

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

891711

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

901984

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.536

High

931037

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

964401

SUMO2
Small ubiquitin-related modifier 2

1

1

Small-scale

0.536

High

1107075

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

Small-scale

0.536

High

1137908

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.536

High

1140647

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.536

High

1178611

KIF7
Kinesin-like protein KIF7

1

1

High-throughput

0.536

High

1197042

AMOT
Angiomotin

1

1

High-throughput

0.536

High

1232977

OTU7B
OTU domain-containing protein 7B

1

1

High-throughput

0.536

High

1235618

K2C80
Keratin, type II cytoskeletal 80

1

1

High-throughput

0.536

High

1251398

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.536

High

1314089

AMOL1
Angiomotin-like protein 1

1

2

High-throughput

0.536

High

1353518

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

High-throughput

0.536

High

1369464

TBC31
TBC1 domain family member 31

1

1

High-throughput

0.536

High

1369475

KIF2C
Kinesin-like protein KIF2C

1

2

High-throughput

0.536

High

1369476

CDC6
Cell division control protein 6 homolog

1

1

High-throughput

0.536

High

1369480

TRAF4
TNF receptor-associated factor 4

1

10

High-throughput

0.536

High

1369486

SDCB2
Syntenin-2

1

1

High-throughput

0.536

High

1369487

RNF41
E3 ubiquitin-protein ligase NRDP1

1

5

High-throughput

0.536

High

1369495

TXLNG
Gamma-taxilin

1

3

High-throughput

0.536

High

1369513

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.536

High

1014571

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.518

High

1369479

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.518

High

1369510

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.518

High

64086

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

193605

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

High-throughput

0.513

High

228041

SSNA1
Microtubule nucleation factor SSNA1

1

0

High-throughput

0.513

High

244178

KIF5C
Kinesin heavy chain isoform 5C

1

0

High-throughput

0.513

High

273910

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.513

High

290096

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.513

High

343628

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.513

High

344760

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.513

High

457895

INVO
Involucrin

1

0

High-throughput

0.513

High

483457

ANXA4
Annexin A4

1

0

High-throughput

0.513

High

625538

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

649748

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

692767

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

720130

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.513

High

724501

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

729382

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.513

High

767289

MERL
Merlin

1

0

High-throughput

0.513

High

789188

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.513

High

828874

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

845341

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

0

High-throughput

0.513

High

885549

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

898515

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.513

High

908846

NEK2
Serine/threonine-protein kinase Nek2

1

0

High-throughput

0.513

High

931977

EPHB4
Ephrin type-B receptor 4

1

0

High-throughput

0.513

High

946177

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

968648

NCS1
Neuronal calcium sensor 1

1

0

High-throughput

0.513

High

993280

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

1005706

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.513

High

1068274

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

1110280

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

0

High-throughput

0.513

High

1131694

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

1136992

SEPT2
Septin-2

1

0

High-throughput

0.513

High

1140123

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1143218

PLEC
Plectin

1

0

High-throughput

0.513

High

1147085

ELOC
Elongin-C

1

0

High-throughput

0.513

High

1151608

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.513

High

1157544

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

1218618

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.513

High

1220471

K2C79
Keratin, type II cytoskeletal 79

1

0

High-throughput

0.513

High

1226205

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.513

High

1243294

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.513

High

1244482

ULK3
Serine/threonine-protein kinase ULK3

1

0

High-throughput

0.513

High

1244810

FBX38
F-box only protein 38

1

0

High-throughput

0.513

High

1248166

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

High-throughput

0.513

High

1271983

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1280037

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

High-throughput

0.513

High

1288081

SAPC2
Suppressor APC domain-containing protein 2

1

0

High-throughput

0.513

High

1288552

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.513

High

1290461

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.513

High

1295366

GPSM1
G-protein-signaling modulator 1

1

0

High-throughput

0.513

High

1295518

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.513

High

1308872

CCD50
Coiled-coil domain-containing protein 50

1

0

High-throughput

0.513

High

1337394

CC112
Coiled-coil domain-containing protein 112

1

0

High-throughput

0.513

High

1357857

ZFN2B
AN1-type zinc finger protein 2B

1

0

High-throughput

0.513

High

1359527

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

1365324

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.513

High

1369465

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

High-throughput

0.513

High

1369467

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.513

High

1369469

FUBP3
Far upstream element-binding protein 3

1

0

High-throughput

0.513

High

1369473

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1369484

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.513

High

1369490

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.513

High

1369492

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1369493

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

1369494

PICK1
PRKCA-binding protein

1

0

High-throughput

0.513

High

1369496

PARVA
Alpha-parvin

1

0

High-throughput

0.513

High

1369497

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

1369498

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

1369503

TEN3
Teneurin-3

1

0

High-throughput

0.513

High

1369506

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

1369507

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.513

High

1369509

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.513

High

1369512

APC7
Anaphase-promoting complex subunit 7

1

0

High-throughput

0.513

High

1369516

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

1369517

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

654545

FBLN1
Fibulin-1

1

1

High-throughput

0.494

High

443903

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

High-throughput

0.489

High

680450

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

769760

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.489

High

829255

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.489

High

1127621

HABP2
Factor VII-activating protease

1

1

High-throughput

0.489

High

1131482

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

High-throughput

0.489

High

1311674

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

1

High-throughput

0.489

High

1360032

OIT3
Oncoprotein-induced transcript 3 protein

1

2

High-throughput

0.489

High

1369097

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

2

High-throughput

0.489

High

1369483

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.489

High

422769

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

407498

K2C1
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.479

High

476366

K1C16
Keratin, type I cytoskeletal 16

1

2

High-throughput

0.479

High

535371

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

537637

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

761471

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.479

High

772038

K1C9
Keratin, type I cytoskeletal 9

1

3

High-throughput

0.479

High

801437

HSPA9
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

834498

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

1109638

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

Small-scale

0.479

High

1132402

CASP8
Caspase-8

1

1

Small-scale

0.479

High

1227190

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1278053

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.479

High

1350394

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1366939

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1369460

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

3

Small-scale

0.479

High

1369466

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

1369474

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

Small-scale

0.479

High

1369504

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

911030

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

921737

COPB
Coatomer subunit beta

1

0

High-throughput

0.460

High

1096611

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.460

High

1369485

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.460

High

134108

IPO5
Importin-5

1

0

High-throughput

0.458

High

161572

ITBP1
Integrin beta-1-binding protein 1

1

0

Small-scale

0.458

High

323511

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

High-throughput

0.458

High

342992

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

926516

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

936825

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

1026159

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

1027639

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

1097950

CBLB
E3 ubiquitin-protein ligase CBL-B

1

0

Small-scale

0.458

High

1113899

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1131091

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

1139656

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

1150555

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

1276580

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1369461

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

Small-scale

0.458

High

1369470

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.458

High

1369502

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

Small-scale

0.458

High

1369482

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.457

High

520614

RARA
Retinoic acid receptor alpha

1

1

Small-scale

0.445

High

991390

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.445

High

622653

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.437

High

1369514

Q9UQC1
Heat shock protein 72

1

3

High-throughput

0.437

High

64837

PSAL
Puromycin-sensitive aminopeptidase-like protein

1

0

High-throughput

0.426

High

725633

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

0

High-throughput

0.426

High

870493

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.426

High

1116437

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.426

High

1155374

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.426

High

379123

IGKC
Immunoglobulin kappa constant

1

2

High-throughput

0.407

High

379287

IGHG1
Immunoglobulin heavy constant gamma 1

1

2

High-throughput

0.407

High

379691

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

1051504

SRS11
Serine/arginine-rich splicing factor 11

1

0

High-throughput

0.299

High

520952

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.282

High

726686

SDC4
Syndecan-4

1

0

High-throughput

0.282

High

1102430

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.282

High

124428

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

378707

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

634949

MIME
Mimecan

1

0

High-throughput

0.279

Low

762248

TRY3
Trypsin-3

1

0

High-throughput

0.279

Low

1090358

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.279

Low

1201823

SDK2
Protein sidekick-2

1

0

High-throughput

0.279

Low

1210085

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.279

Low

1248279

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.279

Low

1258901

H32
Histone H3.2

1

0

High-throughput

0.279

Low

1293731

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

1312567

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.279

Low

1335837

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

0

High-throughput

0.279

Low

1356663

ARB2A
Cotranscriptional regulator ARB2A

1

0

High-throughput

0.279

Low

1369462

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.279

Low

1369463

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

1369468

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.279

Low

1369471

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.279

Low

1369477

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.279

Low

1369478

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

1369481

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.279

Low

1369488

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

1369489

NOL6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

1369491

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.279

Low

1369500

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

0

High-throughput

0.279

Low

1369501

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.279

Low

1369505

MRC2
C-type mannose receptor 2

1

0

High-throughput

0.279

Low

1369511

TRM6
tRNA

1

0

High-throughput

0.279

Low

535878

LAMC1
Laminin subunit gamma-1

1

0

High-throughput

0.251

Low

910611

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.249

Low

1256540

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025