Protein: PRIO
Major prion protein (PrP) (PrP27-30) (PrP33-35C) (CD antigen CD230)

Gene: PRIO, Prnp
Organism: Mus musculus
Interactions: 60
UniProt ID: P04925

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001540 - amyloid-beta binding
GO:0002020 - protease binding
GO:0005507 - copper ion binding
GO:0005521 - lamin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

420070

PRIO
Major prion protein

7

4

Small-scale

0.969

High

420076

A4
Amyloid-beta precursor protein

4

3

Small-scale

0.689

High

420097

MOG
Myelin-oligodendrocyte glycoprotein

1

0

Small-scale

0.631

High

420096

GRB2
Growth factor receptor-bound protein 2

2

1

Small-scale

0.621

High

420114

NECT1
Nectin-1

1

8

Small-scale

0.618

High

420119

DPP6
A-type potassium channel modulatory protein DPP6

2

1

Small-scale

0.601

High

420108

IGSF8
Immunoglobulin superfamily member 8

1

0

Small-scale

0.586

High

420115

PRND
Prion-like protein doppel

1

0

Small-scale

0.586

High

420111

CADM3
Cell adhesion molecule 3

1

5

Small-scale

0.553

High

420094

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.536

High

204318

NCAM2
Neural cell adhesion molecule 2

1

5

Small-scale

0.515

High

420072

PDIA1
Protein disulfide-isomerase

1

1

Small-scale

0.515

High

420077

CNTN1
Contactin-1

1

3

Small-scale

0.515

High

420078

NCAM1
Neural cell adhesion molecule 1

1

3

Small-scale

0.515

High

420081

MAG
Myelin-associated glycoprotein

1

7

Small-scale

0.515

High

420091

APLP2
Amyloid beta precursor like protein 2

1

3

Small-scale

0.515

High

420103

LSAMP
Limbic system-associated membrane protein

1

8

Small-scale

0.515

High

420113

CSTN1
Calsyntenin-1

1

1

Small-scale

0.515

High

420071

APOE
Apolipoprotein E

1

0

Small-scale

0.493

High

420080

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.493

High

420092

CLUS
Clusterin

1

0

Small-scale

0.493

High

420116

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

Small-scale

0.493

High

59262

A2AFG8
Neural cell adhesion molecule L1

1

3

Small-scale

0.479

High

109247

G5E8G3
Opioid binding protein/cell adhesion molecule-like

1

5

Small-scale

0.479

High

147460

DPYL2
Dihydropyrimidinase-related protein 2

1

1

Small-scale

0.479

High

313168

SYN1
Synapsin-1

1

3

Small-scale

0.479

High

408242

MBP
Myelin basic protein

1

1

Small-scale

0.479

High

420074

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.479

High

420075

L1CAM
Neural cell adhesion molecule L1

1

3

Small-scale

0.479

High

420079

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

Small-scale

0.479

High

420084

MYPR
Myelin proteolipid protein

1

2

Small-scale

0.479

High

420086

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

Small-scale

0.479

High

420087

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

420090

APLP1
Amyloid beta precursor like protein 1

1

3

Small-scale

0.479

High

420099

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

4

Small-scale

0.479

High

420100

TAOK2
Serine/threonine-protein kinase TAO2

1

1

High-throughput

0.479

High

420101

Q8BG33
Neurotrimin

1

8

Small-scale

0.479

High

420104

Q8BMT5
Ig-like domain-containing protein

1

5

Small-scale

0.479

High

420109

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

Small-scale

0.479

High

420112

NTRI
Neurotrimin

1

7

Small-scale

0.479

High

420117

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

6

Small-scale

0.479

High

147395

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

0

Small-scale

0.458

High

147924

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.458

High

420083

PRS7
26S proteasome regulatory subunit 7

1

0

Small-scale

0.458

High

420085

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

420088

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.458

High

420093

GRM5
Metabotropic glutamate receptor 5

1

0

Small-scale

0.458

High

420102

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.458

High

420105

ERI3
ERI1 exoribonuclease 3

1

0

Small-scale

0.458

High

420106

PDE10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

1

0

Small-scale

0.458

High

420107

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

420073

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.438

High

420082

DYN1
Dynamin-1

1

0

Small-scale

0.269

Low

420089

SPRL1
SPARC-like protein 1

1

0

Small-scale

0.269

Low

420118

ADA23
Disintegrin and metalloproteinase domain-containing protein 23

1

0

Small-scale

0.269

Low

398016

CFAD
Complement factor D

1

0

High-throughput

0.249

Low

420095

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.249

Low

420098

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.249

Low

420110

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025