Protein: MCES
mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)

Gene: MCES, RNMT
Organism: Homo sapiens
Interactions: 56
UniProt ID: O43148

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0004482 - mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

207765

RAMAC
RNA guanine-N7 methyltransferase activating subunit

6

0

High-throughput

0.898

High

207719

IMA7
Importin subunit alpha-7

6

5

High-throughput

0.734

High

207743

IMA5
Importin subunit alpha-5

5

5

High-throughput

0.720

High

207742

IMA1
Importin subunit alpha-1

3

5

High-throughput

0.665

High

179008

IMA6
Importin subunit alpha-6

3

5

High-throughput

0.662

High

207725

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

207763

GMCL1
Germ cell-less protein-like 1

2

0

High-throughput

0.580

High

207729

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.554

High

207768

PKHA3
Pleckstrin homology domain-containing family A member 3

2

1

High-throughput

0.553

High

142454

IMA3
Importin subunit alpha-3

1

5

High-throughput

0.536

High

207747

CUL1
Cullin-1

1

3

High-throughput

0.536

High

207748

CUL2
Cullin-2

1

3

High-throughput

0.536

High

207749

CUL3
Cullin-3

1

3

High-throughput

0.536

High

207760

CUL5
Cullin-5

1

3

High-throughput

0.536

High

207734

EGLN
Endoglin

1

0

High-throughput

0.513

High

207751

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

207755

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

207759

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

207762

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

207721

MCE1
mRNA-capping enzyme

1

1

Small-scale

0.501

High

207726

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

207730

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

207736

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

207738

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

207746

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

207750

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

207718

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

207720

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

207722

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

207724

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

207727

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

207732

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

207733

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

207735

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

Small-scale

0.458

High

207737

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

207739

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

207740

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

207741

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

207744

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

207745

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

207754

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

207758

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.458

High

207764

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

207770

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

207731

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

207728

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

207761

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.426

High

207757

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.328

High

207752

H90B4
Putative heat shock protein HSP 90-beta 4

2

0

High-throughput

0.288

High

207753

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

207766

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

207767

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

207769

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

62418

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

207723

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

207756

TRI58
E3 ubiquitin-protein ligase TRIM58

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025