Protein: RS21
Small ribosomal subunit protein eS21 (40S ribosomal protein S21)

Gene: RS21, RPS21
Organism: Homo sapiens
Interactions: 170
UniProt ID: P63220

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445360

RSSA
Small ribosomal subunit protein uS2

8

15

Small-scale

0.969

High

550717

RS2
Small ribosomal subunit protein uS5

3

3

High-throughput

0.827

High

346470

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.633

High

929199

CUL3
Cullin-3

2

1

High-throughput

0.611

High

418151

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

929200

BYST
Bystin

2

2

High-throughput

0.601

High

788810

RS27
Small ribosomal subunit protein eS27

2

3

High-throughput

0.584

High

47403

RPSA2
Small ribosomal subunit protein uS2B

1

15

High-throughput

0.575

High

369360

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

805383

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

1

High-throughput

0.571

High

929197

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

1

High-throughput

0.571

High

929213

LARP7
La-related protein 7

2

0

High-throughput

0.559

High

235070

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

929207

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

152958

RIOK3
Serine/threonine-protein kinase RIO3

1

5

High-throughput

0.536

High

230858

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.536

High

643316

HMGB2
High mobility group protein B2

1

3

High-throughput

0.536

High

759608

RS19
Small ribosomal subunit protein eS19

1

4

High-throughput

0.536

High

805948

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

851438

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

879222

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.536

High

907835

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

929187

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

929188

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

929196

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.536

High

929198

CUL1
Cullin-1

1

1

High-throughput

0.536

High

929212

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.536

High

929243

DNJC2
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.536

High

929246

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

929267

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

929269

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

255123

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

283484

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

337421

ABL1
Tyrosine-protein kinase ABL1

1

0

High-throughput

0.513

High

447922

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

508930

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

545833

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

736383

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

828730

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

830899

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

840932

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

844002

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.513

High

873829

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

890092

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

922959

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

929194

TP53B
TP53-binding protein 1

1

0

High-throughput

0.513

High

929195

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

929203

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

929204

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

929224

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

929232

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

929235

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

929264

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

929268

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

914917

RS4X
Small ribosomal subunit protein eS4, X isoform

1

2

Small-scale

0.501

High

929221

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.481

High

929237

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

1

High-throughput

0.481

High

394504

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

893885

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

125354

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

224401

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

227120

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

294678

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

298401

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

312563

ARI2
E3 ubiquitin-protein ligase ARIH2

1

2

High-throughput

0.479

High

379257

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

487316

ANDR
Androgen receptor

1

2

Small-scale

0.479

High

509618

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.479

High

640428

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

649439

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

737728

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

780678

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.479

High

817653

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

830327

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.479

High

911333

RS11
Small ribosomal subunit protein uS17

1

3

High-throughput

0.479

High

929190

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

929191

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

929192

TLE2
Transducin-like enhancer protein 2

1

1

High-throughput

0.479

High

929206

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.479

High

929209

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

929210

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.479

High

929214

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

929216

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

929227

THOC2
THO complex subunit 2

1

1

High-throughput

0.479

High

929230

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

1

High-throughput

0.479

High

929234

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

929236

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

929238

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

929250

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

929252

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

929253

ENY2
Transcription and mRNA export factor ENY2

1

1

High-throughput

0.479

High

929261

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.479

High

929266

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

929257

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

122644

MEN1
Menin

1

0

High-throughput

0.458

High

148657

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

242695

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

268971

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

278776

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

282876

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.458

High

296651

SLIT2
Slit homolog 2 protein

1

0

High-throughput

0.458

High

303133

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

342555

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

442039

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

449238

LEG1
Galectin-1

1

0

Small-scale

0.458

High

569560

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

625336

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

650919

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

683950

1433S
14-3-3 protein sigma

1

0

Small-scale

0.458

High

720201

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

779209

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

813364

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

817900

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

877683

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

894926

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.458

High

896022

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

908331

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

929189

H31
Histone H3.1

1

0

High-throughput

0.458

High

929193

AKP13
A-kinase anchor protein 13

1

0

High-throughput

0.458

High

929201

ELOA1
Elongin-A

1

0

High-throughput

0.458

High

929202

SRC8
Src substrate cortactin

1

0

High-throughput

0.458

High

929205

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

929208

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

929211

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

929215

CI114
Putative methyltransferase C9orf114

1

0

High-throughput

0.458

High

929218

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

929219

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

929220

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

929222

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

929223

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

929225

PHF6
PHD finger protein 6

1

0

High-throughput

0.458

High

929226

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

929228

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

929231

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

929233

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

929239

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

929240

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

929241

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.458

High

929242

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

929245

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

929248

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

929254

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

929255

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

929256

ANLN
Anillin

1

0

High-throughput

0.458

High

929260

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

929262

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

929263

TES
Testin

1

0

High-throughput

0.458

High

929272

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

929244

RIOK1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.445

High

374025

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

496803

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

528945

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

929249

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

233750

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.407

High

735046

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

929217

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.316

High

929251

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

581654

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

352053

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

363049

FINC
Fibronectin

1

0

High-throughput

0.249

Low

390818

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

530605

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

674646

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

929229

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

929247

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

929259

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.249

Low

929265

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.249

Low

929270

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

929271

MAFB
Transcription factor MafB

1

0

High-throughput

0.249

Low

929258

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024