Protein: 5HT3A
5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)

Gene: 5HT3A, HTR3A
Organism: Homo sapiens
Interactions: 120
UniProt ID: P46098

Gene Ontology (top 5):
GO:0005231 - excitatory extracellular ligand-gated monoatomic ion channel activity
GO:0005886 - plasma membrane
GO:0007210 - serotonin receptor signaling pathway
GO:0007268 - chemical synaptic transmission
GO:0022850 - serotonin-gated monoatomic cation channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733690

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

18

High-throughput

0.811

High

855339

BT2A1
Butyrophilin subfamily 2 member A1

1

3

High-throughput

0.691

High

63881

5HT3E
5-hydroxytryptamine receptor 3E

1

19

Small-scale

0.665

High

855338

5HT3D
5-hydroxytryptamine receptor 3D

1

15

Small-scale

0.665

High

855366

5HT3C
5-hydroxytryptamine receptor 3C

1

15

Small-scale

0.665

High

603876

CXA1
Gap junction alpha-1 protein

3

3

High-throughput

0.662

High

855325

SGCB
Beta-sarcoglycan

3

5

High-throughput

0.662

High

855370

ASTRA
Protein Aster-A

3

8

High-throughput

0.662

High

230767

EXTL3
Exostosin-like 3

2

6

High-throughput

0.628

High

320438

TM63A
Mechanosensitive cation channel TMEM63A

2

3

High-throughput

0.628

High

349391

TSN15
Tetraspanin-15

2

1

High-throughput

0.628

High

441590

DOA
HLA class II histocompatibility antigen, DO alpha chain

2

4

High-throughput

0.628

High

520780

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

2

High-throughput

0.628

High

560959

GP1BB
Platelet glycoprotein Ib beta chain

2

5

High-throughput

0.628

High

661237

AT2B4
Plasma membrane calcium-transporting ATPase 4

2

2

High-throughput

0.628

High

783032

CXG1
Gap junction gamma-1 protein

2

3

High-throughput

0.628

High

855312

S12A2
Solute carrier family 12 member 2

2

6

High-throughput

0.628

High

855314

AT8B2
Phospholipid-transporting ATPase ID

2

4

High-throughput

0.628

High

855315

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

2

High-throughput

0.628

High

855320

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

2

6

High-throughput

0.628

High

855326

ASTRB
Protein Aster-B

2

8

High-throughput

0.628

High

855331

WLS
Protein wntless homolog

2

4

High-throughput

0.628

High

855333

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

9

High-throughput

0.628

High

855334

PLPR3
Phospholipid phosphatase-related protein type 3

2

3

High-throughput

0.628

High

855340

LRC8D
Volume-regulated anion channel subunit LRRC8D

2

9

High-throughput

0.628

High

855349

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

2

5

High-throughput

0.628

High

855351

ABCA7
Phospholipid-transporting ATPase ABCA7

2

4

High-throughput

0.628

High

855353

SIDT2
SID1 transmembrane family member 2

2

6

High-throughput

0.628

High

855357

MSPD2
Motile sperm domain-containing protein 2

2

1

High-throughput

0.628

High

855359

SPPL3
Signal peptide peptidase-like 3

2

10

High-throughput

0.628

High

855360

SPP2B
Signal peptide peptidase-like 2B

2

10

High-throughput

0.628

High

855361

LRC8C
Volume-regulated anion channel subunit LRRC8C

2

9

High-throughput

0.628

High

855364

ABHD3
Phospholipase ABHD3

2

1

High-throughput

0.628

High

855368

TTC17
Tetratricopeptide repeat protein 17

2

2

High-throughput

0.628

High

855373

S47A1
Multidrug and toxin extrusion protein 1

2

2

High-throughput

0.628

High

855377

PANX1
Pannexin-1

2

3

High-throughput

0.628

High

855378

ABCA3
Phospholipid-transporting ATPase ABCA3

2

5

High-throughput

0.628

High

855385

ABCA2
ATP-binding cassette sub-family A member 2

2

4

High-throughput

0.628

High

855392

CNNM1
Metal transporter CNNM1

2

4

High-throughput

0.628

High

855403

LRP12
Low-density lipoprotein receptor-related protein 12

2

4

High-throughput

0.628

High

855321

SQSTM
Sequestosome-1

3

3

High-throughput

0.604

High

855354

LEMD2
LEM domain-containing protein 2

3

9

High-throughput

0.604

High

855363

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

3

5

High-throughput

0.604

High

855383

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

3

1

High-throughput

0.604

High

855398

POMT2
Protein O-mannosyl-transferase 2

3

10

High-throughput

0.604

High

354097

CLPT1
Putative lipid scramblase CLPTM1

2

0

High-throughput

0.602

High

488742

FURIN
Furin

2

0

High-throughput

0.602

High

855311

GPM6A
Neuronal membrane glycoprotein M6-a

2

0

High-throughput

0.602

High

855356

NLGN2
Neuroligin-2

2

0

High-throughput

0.602

High

855375

S41A3
Solute carrier family 41 member 3

2

0

High-throughput

0.602

High

855379

S29A1
Equilibrative nucleoside transporter 1

2

0

High-throughput

0.602

High

855400

GRID1
Glutamate receptor ionotropic, delta-1

2

0

High-throughput

0.602

High

332356

5HT3B
5-hydroxytryptamine receptor 3B

1

17

Small-scale

0.584

High

855310

5HT3A
5-hydroxytryptamine receptor 3A

1

15

Small-scale

0.584

High

539696

ACHB
Acetylcholine receptor subunit beta

1

17

High-throughput

0.575

High

253821

TPST2
Protein-tyrosine sulfotransferase 2

2

5

High-throughput

0.574

High

299868

C1QRF
C1q-related factor

2

8

High-throughput

0.574

High

855316

TAP2
Antigen peptide transporter 2

2

4

High-throughput

0.574

High

855317

P
P protein

2

2

High-throughput

0.574

High

855327

UD3A2
UDP-glucuronosyltransferase 3A2

2

5

High-throughput

0.574

High

855328

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

2

5

High-throughput

0.574

High

855330

DIK1A
Divergent protein kinase domain 1A

2

5

High-throughput

0.574

High

855337

TMTC3
Protein O-mannosyl-transferase TMTC3

2

7

High-throughput

0.574

High

855341

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

3

High-throughput

0.574

High

855342

D19L4
Probable C-mannosyltransferase DPY19L4

2

7

High-throughput

0.574

High

855343

ATG9A
Autophagy-related protein 9A

2

1

High-throughput

0.574

High

855344

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

12

High-throughput

0.574

High

855346

DYR2
Dihydrofolate reductase 2, mitochondrial

2

1

High-throughput

0.574

High

855347

GOLI
E3 ubiquitin-protein ligase RNF130

2

13

High-throughput

0.574

High

855348

C1QL4
Complement C1q-like protein 4

2

8

High-throughput

0.574

High

855355

NETO2
Neuropilin and tolloid-like protein 2

2

7

High-throughput

0.574

High

855362

GPX8
Probable glutathione peroxidase 8

2

2

High-throughput

0.574

High

855369

TM186
Transmembrane protein 186

2

1

High-throughput

0.574

High

855372

C1GLC
C1GALT1-specific chaperone 1

2

3

High-throughput

0.574

High

855374

BSCL2
Seipin

2

4

High-throughput

0.574

High

855380

APOL2
Apolipoprotein L2

2

3

High-throughput

0.574

High

855381

LMF2
Lipase maturation factor 2

2

8

High-throughput

0.574

High

855382

ABHEA
Protein ABHD14A

2

3

High-throughput

0.574

High

855386

COA1
Cytochrome c oxidase assembly factor 1 homolog

2

1

High-throughput

0.574

High

855388

TMX4
Thioredoxin-related transmembrane protein 4

2

1

High-throughput

0.574

High

855389

PCX3
Pecanex-like protein 3

2

3

High-throughput

0.574

High

855390

ALG9
Alpha-1,2-mannosyltransferase ALG9

2

8

High-throughput

0.574

High

855393

TM39A
Transmembrane protein 39A

2

8

High-throughput

0.574

High

855396

TM59L
Transmembrane protein 59-like

2

2

High-throughput

0.574

High

855399

DSE
Dermatan-sulfate epimerase

2

2

High-throughput

0.574

High

855402

RHBD3
Rhomboid domain-containing protein 3

2

5

High-throughput

0.574

High

855404

POMT1
Protein O-mannosyl-transferase 1

2

10

High-throughput

0.574

High

362944

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.536

High

855322

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

2

High-throughput

0.536

High

855335

CF089
Bombesin receptor-activated protein C6orf89

1

1

High-throughput

0.536

High

855345

LSR
Lipolysis-stimulated lipoprotein receptor

1

8

High-throughput

0.536

High

855350

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

9

High-throughput

0.536

High

855365

LMBR1
Limb region 1 protein homolog

1

1

High-throughput

0.536

High

855367

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

212558

GPAA1
GPI-anchor transamidase component GPAA1

1

1

High-throughput

0.489

High

320950

SUN1
SUN domain-containing protein 1

1

2

High-throughput

0.489

High

700777

DMB
HLA class II histocompatibility antigen, DM beta chain

1

4

High-throughput

0.489

High

855318

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

4

High-throughput

0.489

High

855324

NOMO1
BOS complex subunit NOMO1

1

3

High-throughput

0.489

High

855332

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

4

High-throughput

0.489

High

855336

CERS6
Ceramide synthase 6

1

1

High-throughput

0.489

High

855371

F241B
Protein FAM241B

1

1

High-throughput

0.489

High

855376

CREL1
Protein disulfide isomerase CRELD1

1

4

High-throughput

0.489

High

855384

FUT8
Alpha-(1,6)-fucosyltransferase

1

4

High-throughput

0.489

High

855391

ST7
Suppressor of tumorigenicity 7 protein

1

3

High-throughput

0.489

High

855313

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

5

High-throughput

0.407

High

855358

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.407

High

855387

LMA2L
VIP36-like protein

1

1

High-throughput

0.407

High

855395

SEC63
Translocation protein SEC63 homolog

1

9

High-throughput

0.407

High

855397

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

High-throughput

0.407

High

246280

MARH6
E3 ubiquitin-protein ligase MARCHF6

2

0

High-throughput

0.328

High

595986

H12
Histone H1.2

2

0

High-throughput

0.328

High

855352

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

0

High-throughput

0.328

High

855401

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.328

High

855323

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.279

Low

855329

MKS3
Meckelin

1

0

High-throughput

0.279

Low

207802

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.232

Low

855319

OS9
Protein OS-9

1

0

High-throughput

0.232

Low

855394

SE1L1
Protein sel-1 homolog 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025