Protein: NCLN
BOS complex subunit NCLN (Nicalin) (Nicastrin-like protein)

Gene: NCLN
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q969V3

Gene Ontology (top 5):
GO:0003140 - determination of left/right asymmetry in lateral mesoderm
GO:0005789 - endoplasmic reticulum membrane
GO:0009966 - regulation of signal transduction
GO:0016020 - membrane
GO:0032991 - protein-containing complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143654

NOMO1
BOS complex subunit NOMO1

6

3

Small-scale

0.730

High

1205694

NOMO2
BOS complex subunit NOMO2

4

3

High-throughput

0.694

High

1010086

DLK1
Protein delta homolog 1

3

0

High-throughput

0.638

High

1381350

FBX6
F-box only protein 6

4

1

High-throughput

0.633

High

1294228

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.618

High

1334494

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.618

High

669046

FPR2
N-formyl peptide receptor 2

2

0

High-throughput

0.602

High

1280392

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

0

High-throughput

0.585

High

1381322

CCD47
PAT complex subunit CCDC47

2

0

Small-scale

0.585

High

1381360

VAPA
Vesicle-associated membrane protein-associated protein A

2

0

High-throughput

0.585

High

1381365

TMCO1
Calcium load-activated calcium channel

2

0

Small-scale

0.585

High

242513

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

975167

ARF6
ADP-ribosylation factor 6

2

0

High-throughput

0.559

High

1113926

CUL3
Cullin-3

2

0

High-throughput

0.559

High

1381327

CALR3
Calreticulin-3

2

0

High-throughput

0.559

High

130196

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

181391

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

182708

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

538654

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

547333

CP19A
Aromatase

1

1

High-throughput

0.536

High

598168

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

994942

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

1

High-throughput

0.536

High

999547

NOMO3
BOS complex subunit NOMO3

1

3

High-throughput

0.536

High

1131791

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.536

High

1381341

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

1

High-throughput

0.536

High

1381361

DHCR7
7-dehydrocholesterol reductase

1

1

High-throughput

0.536

High

978217

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.533

High

1209484

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

125042

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

133555

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

161238

EI24
Etoposide-induced protein 2.4 homolog

1

0

High-throughput

0.513

High

319959

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.513

High

417653

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

418332

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

785348

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

876377

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.513

High

944298

TMM33
Transmembrane protein 33

1

0

High-throughput

0.513

High

956092

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

975558

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.513

High

1016146

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1122641

MLEC
Malectin

1

0

High-throughput

0.513

High

1126335

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1136148

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.513

High

1136304

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

1205463

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

1238663

TM214
Transmembrane protein 214

1

0

High-throughput

0.513

High

1326860

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

1330342

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.513

High

1349807

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1351771

LRC8C
Volume-regulated anion channel subunit LRRC8C

1

0

High-throughput

0.513

High

1359144

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.513

High

1380513

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

1381325

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.513

High

1381326

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.513

High

1381329

SGCZ
Zeta-sarcoglycan

1

0

High-throughput

0.513

High

1381333

DERL1
Derlin-1

1

0

High-throughput

0.513

High

1381335

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.513

High

1381336

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.513

High

1381337

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.513

High

1381343

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

1381349

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.513

High

1381363

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.513

High

1381366

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1381369

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.513

High

1381370

TBL2
Transducin beta-like protein 2

1

0

High-throughput

0.513

High

1381371

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

1381373

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

301608

WFS1
Wolframin

1

0

High-throughput

0.493

High

843841

HD
Huntingtin

1

0

High-throughput

0.493

High

1142130

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1381321

T106A
Transmembrane protein 106A

1

1

High-throughput

0.489

High

1381364

FBX2
F-box only protein 2

1

1

High-throughput

0.489

High

1381367

GPR55
G-protein coupled receptor 55

1

3

High-throughput

0.489

High

404302

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

420647

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

466396

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

581217

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

953604

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955452

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

962355

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

988590

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

1015657

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1179120

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

1381338

TACAN
Transmembrane protein 120A

1

1

High-throughput

0.479

High

141035

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

229776

CALU
Calumenin

1

0

High-throughput

0.458

High

346160

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

363678

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

412396

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

540609

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

560036

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

766749

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

774536

BASI
Basigin

1

0

High-throughput

0.458

High

800024

COIL
Coilin

1

0

High-throughput

0.458

High

941954

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

951328

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

980101

H4
Histone H4

1

0

High-throughput

0.458

High

1067583

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1107085

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1163793

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

1246912

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1249084

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252166

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1351929

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

1366499

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1380065

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1381323

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1381324

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1381334

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1381351

SERC1
Serine incorporator 1

1

0

High-throughput

0.458

High

1381352

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.458

High

49679

T120B
Transmembrane protein 120B

1

1

High-throughput

0.437

High

126733

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.437

High

318851

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

601400

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.437

High

910158

RND2
Rho-related GTP-binding protein RhoN

1

11

High-throughput

0.437

High

962802

RND3
Rho-related GTP-binding protein RhoE

1

12

High-throughput

0.437

High

1148373

KS6A1
Ribosomal protein S6 kinase alpha-1

1

1

High-throughput

0.437

High

1151814

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.437

High

1238766

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1270936

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.437

High

1366859

RND1
Rho-related GTP-binding protein Rho6

1

12

High-throughput

0.437

High

1366963

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1381328

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.437

High

1381342

RHBT2
Rho-related BTB domain-containing protein 2

1

8

High-throughput

0.437

High

1381346

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.437

High

1381348

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.437

High

1381354

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1381357

ARL15
ADP-ribosylation factor-like protein 15

1

1

High-throughput

0.437

High

211162

CTR4
Cationic amino acid transporter 4

1

0

High-throughput

0.426

High

564171

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1335665

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

1381339

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.426

High

1381340

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

1381359

HACD3
Very-long-chain

1

0

High-throughput

0.426

High

685923

KRA59
Keratin-associated protein 5-9

1

0

High-throughput

0.299

High

401258

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.298

High

219992

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

343186

RAB3D
Ras-related protein Rab-3D

1

0

High-throughput

0.279

Low

553258

KCRB
Creatine kinase B-type

1

0

High-throughput

0.279

Low

936101

PAR2
Proteinase-activated receptor 2

1

0

High-throughput

0.279

Low

1091024

BFSP1
Filensin

1

0

High-throughput

0.279

Low

1381353

CBLN4
Cerebellin-4

1

0

High-throughput

0.279

Low

1381356

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.279

Low

134820

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.249

Low

139954

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

164411

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

218591

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

294128

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

378156

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

459321

CATL1
Procathepsin L

1

0

High-throughput

0.249

Low

566787

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

589343

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

615906

RL17
Large ribosomal subunit protein uL22

1

0

Small-scale

0.249

Low

696139

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768829

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831189

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879338

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

888235

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

970884

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1004934

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1155635

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1162464

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1178292

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1229611

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1254948

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276599

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1312572

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1338313

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1370275

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.249

Low

1370946

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

1380618

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1381330

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.249

Low

1381331

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1381344

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

1381345

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.249

Low

1381347

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1381355

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.249

Low

1381358

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

1381362

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1381368

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1381372

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.249

Low

1094

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

653482

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1157186

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1310910

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.232

Low

1359755

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low

1381332

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025