Protein: ZACN
Ligand-gated cation channel ZACN (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) (Zinc-activated channel)

Gene: ZACN
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q401N2

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005230 - extracellular ligand-gated monoatomic ion channel activity
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding
GO:0010043 - response to zinc ion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560972

GP1BB
Platelet glycoprotein Ib beta chain

3

6

High-throughput

0.667

High

603790

ITA2
Integrin alpha-2

3

1

High-throughput

0.667

High

604006

CXA1
Gap junction alpha-1 protein

3

6

High-throughput

0.667

High

935675

MFAP3
Microfibril-associated glycoprotein 3

3

4

High-throughput

0.667

High

1192259

AT11C
Phospholipid-transporting ATPase IG

3

3

High-throughput

0.667

High

1192262

MSPD2
Motile sperm domain-containing protein 2

3

2

High-throughput

0.667

High

1192265

LRC8C
Volume-regulated anion channel subunit LRRC8C

3

9

High-throughput

0.667

High

1192270

EDA
Ectodysplasin-A

3

5

High-throughput

0.667

High

1192271

HMR1
Major histocompatibility complex class I-related protein 1

3

5

High-throughput

0.667

High

1192278

S47A1
Multidrug and toxin extrusion protein 1

3

3

High-throughput

0.667

High

1192279

S41A3
Solute carrier family 41 member 3

3

1

High-throughput

0.667

High

279575

LAT3
Large neutral amino acids transporter small subunit 3

3

0

High-throughput

0.638

High

1192282

TRPM7
Transient receptor potential cation channel subfamily M member 7

3

0

High-throughput

0.638

High

783041

CXG1
Gap junction gamma-1 protein

2

6

High-throughput

0.611

High

1125845

FZD2
Frizzled-2

2

6

High-throughput

0.611

High

1159149

SGCB
Beta-sarcoglycan

2

5

High-throughput

0.611

High

1192252

TM219
Insulin-like growth factor-binding protein 3 receptor

2

2

High-throughput

0.611

High

1192267

LMBR1
Limb region 1 protein homolog

2

2

High-throughput

0.611

High

1192275

ASTRA
Protein Aster-A

2

9

High-throughput

0.611

High

212575

GPAA1
GPI-anchor transamidase component GPAA1

3

2

High-throughput

0.609

High

299877

C1QRF
C1q-related factor

3

9

High-throughput

0.609

High

320984

SUN1
SUN domain-containing protein 1

3

3

High-throughput

0.609

High

1192244

DIK1A
Divergent protein kinase domain 1A

3

6

High-throughput

0.609

High

1192247

TMTC3
Protein O-mannosyl-transferase TMTC3

3

8

High-throughput

0.609

High

1192249

D19L4
Probable C-mannosyltransferase DPY19L4

3

7

High-throughput

0.609

High

1192256

K2013
Uncharacterized protein KIAA2013

3

3

High-throughput

0.609

High

1192263

MFSD8
Major facilitator superfamily domain-containing protein 8

3

2

High-throughput

0.609

High

1192269

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

3

3

High-throughput

0.609

High

1192288

COA1
Cytochrome c oxidase assembly factor 1 homolog

3

2

High-throughput

0.609

High

1192291

TMX4
Thioredoxin-related transmembrane protein 4

3

3

High-throughput

0.609

High

1192292

ALG9
Alpha-1,2-mannosyltransferase ALG9

3

9

High-throughput

0.609

High

1192296

DNJB9
DnaJ homolog subfamily B member 9

3

3

High-throughput

0.609

High

1192299

CCPG1
Cell cycle progression protein 1

3

4

High-throughput

0.609

High

1192300

FLVC1
Choline/ethanolamine transporter FLVCR1

2

0

High-throughput

0.585

High

409408

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

5

High-throughput

0.571

High

1192248

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

4

High-throughput

0.558

High

1192250

AMGO1
Amphoterin-induced protein 1

2

2

High-throughput

0.558

High

1192268

BRI3B
BRI3-binding protein

2

1

High-throughput

0.558

High

1192276

F241B
Protein FAM241B

2

2

High-throughput

0.558

High

1192295

TM39A
Transmembrane protein 39A

2

9

High-throughput

0.558

High

1192304

POMT1
Protein O-mannosyl-transferase 1

2

10

High-throughput

0.558

High

270457

FZD7
Frizzled-7

1

6

High-throughput

0.536

High

292647

RENR
Renin receptor

1

1

High-throughput

0.536

High

380296

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

6

High-throughput

0.536

High

557336

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

High-throughput

0.536

High

706026

CXB2
Gap junction beta-2 protein

1

6

High-throughput

0.536

High

719721

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

5

High-throughput

0.536

High

878031

AGRE5
Adhesion G protein-coupled receptor E5

1

7

High-throughput

0.536

High

1192246

PLPR3
Phospholipid phosphatase-related protein type 3

1

4

High-throughput

0.536

High

1192260

SIDT2
SID1 transmembrane family member 2

1

7

High-throughput

0.536

High

1192273

TTC17
Tetratricopeptide repeat protein 17

1

3

High-throughput

0.536

High

1192285

CIB1
Calcium and integrin-binding protein 1

1

1

High-throughput

0.536

High

1192302

AGRG1
Adhesion G-protein coupled receptor G1

1

7

High-throughput

0.536

High

723685

NTR1
Neurotensin receptor type 1

1

0

High-throughput

0.513

High

1192280

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.513

High

155587

NEMP1
Nuclear envelope integral membrane protein 1

1

1

High-throughput

0.489

High

994919

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

6

High-throughput

0.489

High

1192253

C1QL4
Complement C1q-like protein 4

1

9

High-throughput

0.489

High

1192261

DIK2A
Divergent protein kinase domain 2A

1

5

High-throughput

0.489

High

1192266

GPX8
Probable glutathione peroxidase 8

1

3

High-throughput

0.489

High

1192274

TM186
Transmembrane protein 186

1

2

High-throughput

0.489

High

1192287

T106C
Transmembrane protein 106C

1

1

High-throughput

0.489

High

1192289

LMA2L
VIP36-like protein

1

2

High-throughput

0.489

High

230795

EXTL3
Exostosin-like 3

1

7

High-throughput

0.479

High

611154

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

890497

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.479

High

933416

S12A2
Solute carrier family 12 member 2

1

6

High-throughput

0.479

High

1192251

GOLI
E3 ubiquitin-protein ligase RNF130

1

13

High-throughput

0.479

High

1192255

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

9

High-throughput

0.479

High

1192284

ABCA3
Phospholipid-transporting ATPase ABCA3

1

6

High-throughput

0.479

High

1192293

PACC1
Proton-activated chloride channel

1

3

High-throughput

0.479

High

1192298

NB5R1
NADH-cytochrome b5 reductase 1

1

4

High-throughput

0.479

High

1192301

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

0

High-throughput

0.458

High

773892

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.437

High

1022398

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.437

High

1192254

GLBL2
Beta-galactosidase-1-like protein 2

1

1

High-throughput

0.437

High

1192264

RDH11
Retinol dehydrogenase 11

1

3

High-throughput

0.437

High

1192277

C1GLC
C1GALT1-specific chaperone 1

1

4

High-throughput

0.437

High

1192286

LMF2
Lipase maturation factor 2

1

9

High-throughput

0.437

High

1192297

FA8A1
Protein FAM8A1

1

2

High-throughput

0.437

High

1192303

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

2

High-throughput

0.437

High

1192245

TM214
Transmembrane protein 214

3

0

High-throughput

0.347

High

1192257

EMC1
ER membrane protein complex subunit 1

3

0

High-throughput

0.347

High

1192258

F241A
Uncharacterized protein FAM241A

3

0

High-throughput

0.347

High

60720

F234B
Protein FAM234B

2

0

High-throughput

0.318

High

178946

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.279

Low

963569

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.279

Low

1192290

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1192294

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

1192272

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

0

High-throughput

0.249

Low

1192281

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.249

Low

1192283

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025