Protein: HCST
Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) (Transmembrane adapter protein KAP10)

Gene: HCST
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q9UBK5

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0006468 - protein phosphorylation
GO:0009986 - cell surface
GO:0030674 - protein-macromolecule adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688716

NKG2D
NKG2-D type II integral membrane protein

2

2

Small-scale

0.584

High

1249517

VSTM1
V-set and transmembrane domain-containing protein 1

2

0

High-throughput

0.580

High

1401251

PANX1
Pannexin-1

2

0

High-throughput

0.576

High

1291518

RETR3
Reticulophagy regulator 3

2

1

High-throughput

0.549

High

411098

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.536

High

565727

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

839183

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

1

High-throughput

0.536

High

839395

MTOR
Serine/threonine-protein kinase mTOR

1

2

High-throughput

0.536

High

896913

DYN2
Dynamin-2

1

1

High-throughput

0.536

High

931307

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

1047250

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

1102283

ATM
Serine-protein kinase ATM

1

3

High-throughput

0.536

High

1177658

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.536

High

1237970

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

3

High-throughput

0.536

High

1259542

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.536

High

1271354

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

3

High-throughput

0.536

High

1290531

LAP4B
Lysosomal-associated transmembrane protein 4B

1

1

High-throughput

0.536

High

1310848

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

3

High-throughput

0.536

High

1351776

LRC8C
Volume-regulated anion channel subunit LRRC8C

1

3

High-throughput

0.536

High

1387076

COQ8B
Atypical kinase COQ8B, mitochondrial

1

1

High-throughput

0.536

High

1416867

TACAN
Transmembrane protein 120A

1

1

High-throughput

0.536

High

1458445

DYN3
Dynamin-3

1

1

High-throughput

0.536

High

65367

TCAF2
TRPM8 channel-associated factor 2

1

0

High-throughput

0.513

High

316639

ST17B
Serine/threonine-protein kinase 17B

1

0

High-throughput

0.513

High

336583

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

614743

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.513

High

637968

NF1
Neurofibromin

1

0

High-throughput

0.513

High

658789

JAK1
Tyrosine-protein kinase JAK1

1

0

High-throughput

0.513

High

835021

S19A1
Reduced folate transporter

1

0

High-throughput

0.513

High

912724

CTR2
Cationic amino acid transporter 2

1

0

High-throughput

0.513

High

1023449

AT8B2
Phospholipid-transporting ATPase ID

1

0

High-throughput

0.513

High

1070183

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.513

High

1112395

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

0

High-throughput

0.513

High

1130727

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.513

High

1153491

EFNB3
Ephrin-B3

1

0

High-throughput

0.513

High

1154829

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.513

High

1228858

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

1232921

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

0

High-throughput

0.513

High

1243062

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

1244913

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

1247716

SARM1
NAD(+) hydrolase SARM1

1

0

High-throughput

0.513

High

1289023

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

1307663

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.513

High

1315145

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

1316781

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.513

High

1324690

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

High-throughput

0.513

High

1332674

MIGA1
Mitoguardin 1

1

0

High-throughput

0.513

High

1337031

T161B
Transmembrane protein 161B

1

0

High-throughput

0.513

High

1349704

CIP2A
Protein CIP2A

1

0

High-throughput

0.513

High

1349732

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.513

High

1371211

GLMN
Glomulin

1

0

High-throughput

0.513

High

1395036

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1401085

XPO6
Exportin-6

1

0

High-throughput

0.513

High

1421257

TTYH3
Protein tweety homolog 3

1

0

High-throughput

0.513

High

1458436

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

High-throughput

0.513

High

1458438

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

1458439

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.513

High

1458442

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.513

High

49710

T120B
Transmembrane protein 120B

1

1

High-throughput

0.489

High

166706

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.489

High

173760

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.489

High

318168

IPO13
Importin-13

1

4

High-throughput

0.489

High

341486

CDS2
Phosphatidate cytidylyltransferase 2

1

1

High-throughput

0.489

High

997170

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.489

High

1036390

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1066039

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.489

High

1108735

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.489

High

1109528

ATR
Serine/threonine-protein kinase ATR

1

3

High-throughput

0.489

High

1118621

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.489

High

1135946

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.489

High

1136729

LAP4A
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.489

High

1142697

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

1191995

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.489

High

1198411

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

1

High-throughput

0.489

High

1200288

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

2

High-throughput

0.489

High

1219363

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.489

High

1225733

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

1

High-throughput

0.489

High

1231483

ATLA3
Atlastin-3

1

1

High-throughput

0.489

High

1287612

ADCK1
AarF domain-containing protein kinase 1

1

1

High-throughput

0.489

High

1334654

RETR2
Reticulophagy regulator 2

1

1

High-throughput

0.489

High

1340119

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

1347324

TTC8
Tetratricopeptide repeat protein 8

1

1

High-throughput

0.489

High

1370215

CDS1
Phosphatidate cytidylyltransferase 1

1

1

High-throughput

0.489

High

1381765

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.489

High

1396410

F210B
Protein FAM210B, mitochondrial

1

1

High-throughput

0.489

High

1398969

F210A
Protein FAM210A

1

1

High-throughput

0.489

High

1410621

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

1413164

NFIP1
NEDD4 family-interacting protein 1

1

1

High-throughput

0.489

High

1435769

AT133
Polyamine-transporting ATPase 13A3

1

2

High-throughput

0.489

High

1437779

XPO5
Exportin-5

1

4

High-throughput

0.489

High

1449525

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

1

High-throughput

0.489

High

1450028

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

1

High-throughput

0.489

High

1450311

NFIP2
NEDD4 family-interacting protein 2

1

1

High-throughput

0.489

High

1458440

XPO7
Exportin-7

1

4

High-throughput

0.489

High

1458449

TNPO3
Transportin-3

1

3

High-throughput

0.489

High

3184

CD3CH
Protein CD300H

1

1

Small-scale

0.445

High

1458443

PCDB8
Protocadherin beta-8

1

1

High-throughput

0.445

High

1458448

PCDB5
Protocadherin beta-5

1

1

High-throughput

0.445

High

142031

FCN1
Ficolin-1

1

0

Small-scale

0.438

High

699880

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.391

High

344500

STR3N
STARD3 N-terminal-like protein

2

0

High-throughput

0.316

High

1394464

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

1332774

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.313

High

62219

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.279

Low

64777

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

1

0

High-throughput

0.279

Low

164657

TNPO2
Transportin-2

1

0

High-throughput

0.279

Low

167132

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.279

Low

183185

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

187570

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.279

Low

193726

TPSN
Tapasin

1

0

High-throughput

0.279

Low

211875

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.279

Low

227138

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

302989

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.279

Low

317939

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

322766

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.279

Low

462815

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

522838

COT1
COUP transcription factor 1

1

0

High-throughput

0.279

Low

642112

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

800241

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.279

Low

829283

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

873422

LSS
Lanosterol synthase

1

0

High-throughput

0.279

Low

884720

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

890904

TSC2
Tuberin

1

0

High-throughput

0.279

Low

944584

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.279

Low

1053844

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.279

Low

1085481

SRBP2
Sterol regulatory element-binding protein 2

1

0

High-throughput

0.279

Low

1103854

TARB1
tRNA

1

0

High-throughput

0.279

Low

1108469

MTX1
Metaxin-1

1

0

High-throughput

0.279

Low

1138904

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1147578

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.279

Low

1149645

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

1179928

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

1180663

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.279

Low

1180704

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.279

Low

1187387

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

0

High-throughput

0.279

Low

1205743

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.279

Low

1218830

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

1224785

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.279

Low

1225981

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1235423

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

1238384

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.279

Low

1239832

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

1240592

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.279

Low

1241648

ANM9
Protein arginine N-methyltransferase 9

1

0

High-throughput

0.279

Low

1243336

INT5
Integrator complex subunit 5

1

0

High-throughput

0.279

Low

1245232

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.279

Low

1251224

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

0

High-throughput

0.279

Low

1251567

THADA
tRNA

1

0

High-throughput

0.279

Low

1258011

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.279

Low

1260324

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

1273973

DYM
Dymeclin

1

0

High-throughput

0.279

Low

1275422

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.279

Low

1278644

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1281076

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

0

High-throughput

0.279

Low

1287790

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

1291729

RTTN
Rotatin

1

0

High-throughput

0.279

Low

1294736

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

1309746

MFN1
Mitofusin-1

1

0

High-throughput

0.279

Low

1310061

DEN6A
Protein DENND6A

1

0

High-throughput

0.279

Low

1313090

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1313233

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.279

Low

1322269

FCSK
L-fucose kinase

1

0

High-throughput

0.279

Low

1323854

INT1
Integrator complex subunit 1

1

0

High-throughput

0.279

Low

1324318

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.279

Low

1325285

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

1325850

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1336182

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1336980

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.279

Low

1351318

DMXL2
DmX-like protein 2

1

0

High-throughput

0.279

Low

1360075

NELFB
Negative elongation factor B

1

0

High-throughput

0.279

Low

1360353

ATRIP
ATR-interacting protein

1

0

High-throughput

0.279

Low

1361374

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1363405

S14L1
SEC14-like protein 1

1

0

High-throughput

0.279

Low

1363880

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.279

Low

1383788

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1384193

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

1384829

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.279

Low

1385119

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1386107

EVI5L
EVI5-like protein

1

0

High-throughput

0.279

Low

1386935

F241B
Protein FAM241B

1

0

High-throughput

0.279

Low

1395011

RADIL
Ras-associating and dilute domain-containing protein

1

0

High-throughput

0.279

Low

1395593

FACR2
Fatty acyl-CoA reductase 2

1

0

High-throughput

0.279

Low

1406955

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.279

Low

1411634

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.279

Low

1413036

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.279

Low

1413747

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1428902

TM39B
Transmembrane protein 39B

1

0

High-throughput

0.279

Low

1430048

INT2
Integrator complex subunit 2

1

0

High-throughput

0.279

Low

1431221

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.279

Low

1431690

ARV1
Protein ARV1

1

0

High-throughput

0.279

Low

1434878

PCX3
Pecanex-like protein 3

1

0

High-throughput

0.279

Low

1437821

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.279

Low

1449044

HELLS
Lymphoid-specific helicase

1

0

High-throughput

0.279

Low

1449709

MDN1
Midasin

1

0

High-throughput

0.279

Low

1452122

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.279

Low

1452587

ZDHC3
Palmitoyltransferase ZDHHC3

1

0

High-throughput

0.279

Low

1453082

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.279

Low

1458435

TRM7
tRNA

1

0

High-throughput

0.279

Low

1458437

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

1458441

NOCT
Nocturnin

1

0

High-throughput

0.279

Low

1458444

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

0

High-throughput

0.279

Low

1458446

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.279

Low

1458447

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low

1458450

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.279

Low

660303

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.268

Low

316581

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.232

Low

1197288

MBRL
Membralin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025