Protein: ISCU
Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein)

Gene: ISCU
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9H1K1

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431152

NFS1
Cysteine desulfurase

2

7

Small-scale

0.806

High

1310396

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

4

Small-scale

0.678

High

1049770

1433F
14-3-3 protein eta

3

6

High-throughput

0.662

High

1431148

LYRM4
LYR motif-containing protein 4

3

2

Small-scale

0.656

High

789221

NUP62
Nuclear pore glycoprotein p62

3

0

High-throughput

0.646

High

1159360

FRDA
Frataxin, mitochondrial

1

2

Small-scale

0.618

High

1279976

NECA2
N-terminal EF-hand calcium-binding protein 2

2

0

High-throughput

0.613

High

300493

KRT34
Keratin, type I cuticular Ha4

2

1

High-throughput

0.606

High

1165316

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

0

High-throughput

0.602

High

361923

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

2

0

High-throughput

0.601

High

730881

1433S
14-3-3 protein sigma

2

6

High-throughput

0.601

High

971988

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.585

High

1431149

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

641834

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

Small-scale

0.576

High

1230256

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.573

High

730229

1433B
14-3-3 protein beta/alpha

2

6

High-throughput

0.571

High

65162

GG6L9
Golgin subfamily A member 6-like protein 9

2

1

High-throughput

0.553

High

505679

CC172
Coiled-coil domain-containing protein 172

1

0

High-throughput

0.549

High

1104669

IKZF1
DNA-binding protein Ikaros

1

0

High-throughput

0.549

High

1316985

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

1332040

BANP
Protein BANP

1

0

High-throughput

0.549

High

1348495

LNX1
E3 ubiquitin-protein ligase LNX

1

0

High-throughput

0.549

High

1431151

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

0

High-throughput

0.549

High

966862

1433G
14-3-3 protein gamma

1

6

High-throughput

0.536

High

990719

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.536

High

869231

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.530

High

1217053

LYRM7
Complex III assembly factor LYRM7

1

0

High-throughput

0.530

High

1063610

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

239335

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

0

High-throughput

0.513

High

1323716

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.513

High

279906

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

471243

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

1090533

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

65430

SDHF1
Succinate dehydrogenase assembly factor 1, mitochondrial

1

0

Small-scale

0.464

High

159850

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

828952

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1114269

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1142663

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1220790

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1431150

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

691421

1433T
14-3-3 protein theta

1

6

High-throughput

0.445

High

801520

HSPA9
Stress-70 protein, mitochondrial

1

5

Small-scale

0.445

High

1065681

RBL2
Retinoblastoma-like protein 2

1

0

Small-scale

0.426

High

1258574

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

1251687

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

1332434

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.316

High

1247413

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

1395344

CC136
Coiled-coil domain-containing protein 136

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025