Protein: HPRT
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)

Gene: HPRT, HPRT1
Organism: Homo sapiens
Interactions: 124
UniProt ID: P00492

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000287 - magnesium ion binding
GO:0001913 - T cell mediated cytotoxicity
GO:0001975 - response to amphetamine
GO:0004422 - hypoxanthine phosphoribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361928

PRDC1
Phosphoribosyltransferase domain-containing protein 1

10

5

High-throughput

0.979

High

361832

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

5

5

Small-scale

0.918

High

361907

NTAQ1
Protein N-terminal glutamine amidohydrolase

6

1

High-throughput

0.740

High

140099

SDCB1
Syntenin-1

4

0

High-throughput

0.668

High

361882

CUL3
Cullin-3

2

1

High-throughput

0.611

High

361906

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

2

1

High-throughput

0.606

High

361931

SPG21
Maspardin

2

1

High-throughput

0.606

High

361923

ISCU
Iron-sulfur cluster assembly enzyme ISCU

2

0

High-throughput

0.601

High

361866

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.588

High

361886

GNMT
Glycine N-methyltransferase

2

0

High-throughput

0.580

High

361890

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

240426

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

361860

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

361924

ATG5
Autophagy protein 5

2

0

High-throughput

0.559

High

361869

CASP9
Caspase-9

2

0

High-throughput

0.547

High

361842

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

361904

CUL5
Cullin-5

1

1

High-throughput

0.536

High

361912

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

361921

SHRPN
Sharpin

1

1

High-throughput

0.536

High

361894

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

135440

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

213755

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

361845

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

361857

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.513

High

361878

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

361917

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

361939

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

261684

HUS1
Checkpoint protein HUS1

1

0

High-throughput

0.493

High

361851

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

361861

HD
Huntingtin

1

0

High-throughput

0.493

High

361877

TIE2
Angiopoietin-1 receptor

1

0

High-throughput

0.479

High

125126

LEG9
Galectin-9

1

1

High-throughput

0.479

High

361839

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.479

High

361846

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

High-throughput

0.479

High

361848

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

361858

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

361862

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

361871

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.479

High

361875

RHOB
Rho-related GTP-binding protein RhoB

1

2

High-throughput

0.479

High

361876

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

361883

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

361892

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

361900

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

361918

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

361920

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

361938

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

187433

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

293008

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

314995

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

324382

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

345233

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

349724

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

361834

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

361836

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

361838

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

361840

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

361843

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

361853

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

361855

BASI
Basigin

1

0

High-throughput

0.458

High

361859

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

361865

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

361867

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

361868

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

361870

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

361872

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

361873

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

361874

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

361879

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

361881

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

361885

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

361887

CUL7
Cullin-7

1

0

High-throughput

0.458

High

361888

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

361889

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

361891

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

361895

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

361899

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

361901

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

361902

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

361908

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

361909

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

361911

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

361913

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

361914

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

361916

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

361925

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

361926

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

361927

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.458

High

361929

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

361930

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

361932

TRM7
tRNA

1

0

High-throughput

0.458

High

361933

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

361934

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

361935

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

361937

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

327716

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

361849

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

361922

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

361833

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

361835

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

361856

FUS
RNA-binding protein FUS

1

2

High-throughput

0.437

High

361893

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

361896

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

361919

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

361844

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

361905

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

361837

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

361864

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

361897

EFCB3
EF-hand calcium-binding domain-containing protein 3

2

0

High-throughput

0.316

High

361898

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.316

High

361841

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

361915

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.279

Low

254498

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.269

Low

352815

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

361847

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

361852

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

361854

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

361863

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

361880

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

361884

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

361903

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

361910

LMTK3
Serine/threonine-protein kinase LMTK3

1

0

High-throughput

0.249

Low

361936

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

361850

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025