Protein: FOLC
Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)

Gene: FOLC, FPGS
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q05932

Gene Ontology (top 5):
GO:0004326 - tetrahydrofolylpolyglutamate synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777605

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

3

1

High-throughput

0.656

High

1052955

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

1052958

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

271039

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

842200

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

1052956

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1052959

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1052964

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1052967

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

182516

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

241474

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

1052954

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1052957

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1052961

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1052966

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

72922

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

295573

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.426

High

844922

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.426

High

562015

LAMP2
Lysosome-associated membrane glycoprotein 2

2

0

High-throughput

0.328

High

1052962

LIPH
Lipase member H

2

0

High-throughput

0.318

High

1052965

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

1052960

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.288

High

1052968

PLAK2
PALM2-AKAP2 fusion protein

2

0

High-throughput

0.288

High

377110

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

719779

V2R
Vasopressin V2 receptor

1

0

High-throughput

0.279

Low

880132

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1052952

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1052963

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1052953

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

628404

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025