Protein: THEM4
Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)

Gene: THEM4
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q5T1C6

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1211836

THEM5
Acyl-coenzyme A thioesterase THEM5

2

0

High-throughput

0.736

High

728284

AKT1
RAC-alpha serine/threonine-protein kinase

4

0

Small-scale

0.661

High

177553

MRPP3
Mitochondrial ribonuclease P catalytic subunit

2

1

High-throughput

0.628

High

1211830

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

2

1

High-throughput

0.628

High

1211834

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

2

1

High-throughput

0.628

High

1211837

ALAT2
Alanine aminotransferase 2

2

1

High-throughput

0.628

High

539340

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

2

0

High-throughput

0.602

High

560873

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

0

High-throughput

0.602

High

942409

CLD18
Claudin-18

2

0

High-throughput

0.602

High

1052955

FOLC
Folylpolyglutamate synthase, mitochondrial

2

0

High-throughput

0.602

High

1106425

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

1211857

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

2

0

High-throughput

0.602

High

1211861

ENOPH
Enolase-phosphatase E1

2

0

High-throughput

0.602

High

506806

GSTT2
Glutathione S-transferase theta-2B

2

1

High-throughput

0.584

High

279786

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1087411

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

1162361

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

506801

GST2
Glutathione S-transferase theta-2

2

1

High-throughput

0.552

High

1103981

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.513

High

1211849

ULBP1
UL16-binding protein 1

1

0

High-throughput

0.513

High

1211850

KLC2
Kinesin light chain 2

1

0

High-throughput

0.513

High

1211851

CARD9
Caspase recruitment domain-containing protein 9

1

0

High-throughput

0.513

High

374661

RASH
GTPase HRas

1

0

High-throughput

0.493

High

474731

VIME
Vimentin

1

0

High-throughput

0.493

High

593755

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

650218

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.493

High

1211833

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

281972

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

287306

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

856281

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

1083633

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1211832

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

1211838

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

1211843

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1211845

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1211858

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

1211860

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

61519

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

350891

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

471069

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

532647

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

786122

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

828800

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841774

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851911

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882712

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

958961

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1015502

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

1024065

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1058064

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090427

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1117752

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1142564

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1207033

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1211831

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1211835

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1211839

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1211840

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1211841

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1211842

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1211844

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1211846

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1211847

TR61B
tRNA

1

0

High-throughput

0.458

High

1211848

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1211852

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1211853

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1211854

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1211855

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1211856

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1211859

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1211862

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1211863

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

377058

COLI
Pro-opiomelanocortin

1

0

High-throughput

0.279

Low

1200220

LBH
Protein LBH

1

0

High-throughput

0.279

Low

1211864

Q9Y649
GW128

1

0

High-throughput

0.268

Low

418190

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025