Protein: V2R
Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)

Gene: V2R, AVPR2
Organism: Homo sapiens
Interactions: 129
UniProt ID: P30518

Gene Ontology (top 5):
GO:0001992 - regulation of systemic arterial blood pressure by vasopressin
GO:0003084 - positive regulation of systemic arterial blood pressure
GO:0003092 - renal water retention
GO:0005000 - vasopressin receptor activity
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

719763

V2R
Vasopressin V2 receptor

1

17

Small-scale

0.724

High

316600

ST17B
Serine/threonine-protein kinase 17B

1

3

High-throughput

0.691

High

719765

TTK
Dual specificity protein kinase TTK

1

5

High-throughput

0.691

High

719813

ARRD4
Arrestin domain-containing protein 4

1

17

Small-scale

0.665

High

719775

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

15

Small-scale

0.647

High

691642

MK03
Mitogen-activated protein kinase 3

1

3

Small-scale

0.618

High

719764

ARRB2
Beta-arrestin-2

1

13

Small-scale

0.618

High

719766

GRK5
G protein-coupled receptor kinase 5

1

11

Small-scale

0.618

High

719808

S41A1
Solute carrier family 41 member 1

2

2

High-throughput

0.606

High

642199

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.580

High

49587

GXLT2
Glucoside xylosyltransferase 2

1

2

High-throughput

0.536

High

65337

TCAF2
TRPM8 channel-associated factor 2

1

1

High-throughput

0.536

High

163245

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

3

High-throughput

0.536

High

226409

SNG2
Synaptogyrin-2

1

3

High-throughput

0.536

High

248563

FADS1
Acyl-CoA

1

2

High-throughput

0.536

High

252834

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.536

High

255989

S19A2
Thiamine transporter 1

1

1

High-throughput

0.536

High

269993

XYLK
Glycosaminoglycan xylosylkinase

1

1

High-throughput

0.536

High

295907

SC5D
Lathosterol oxidase

1

2

High-throughput

0.536

High

336527

PIGN
GPI ethanolamine phosphate transferase 1

1

5

High-throughput

0.536

High

399662

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.536

High

603850

CXA1
Gap junction alpha-1 protein

1

7

High-throughput

0.536

High

661228

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

19

High-throughput

0.536

High

665066

COT2
COUP transcription factor 2

1

2

High-throughput

0.536

High

719767

BLK
Tyrosine-protein kinase Blk

1

6

High-throughput

0.536

High

719768

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.536

High

719769

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.536

High

719773

SELT
Thioredoxin reductase-like selenoprotein T

1

1

High-throughput

0.536

High

719776

AT8B2
Phospholipid-transporting ATPase ID

1

15

High-throughput

0.536

High

719778

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

17

High-throughput

0.536

High

719780

ATM
Serine-protein kinase ATM

1

12

High-throughput

0.536

High

719781

TMED1
Transmembrane emp24 domain-containing protein 1

1

3

High-throughput

0.536

High

719782

STAR3
StAR-related lipid transfer protein 3

1

1

High-throughput

0.536

High

719784

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

16

High-throughput

0.536

High

719785

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

4

High-throughput

0.536

High

719786

D19L1
Protein C-mannosyl-transferase DPY19L1

1

1

High-throughput

0.536

High

719788

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

1

High-throughput

0.536

High

719792

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

7

High-throughput

0.536

High

719795

RINT1
RAD50-interacting protein 1

1

4

High-throughput

0.536

High

719796

ZNT6
Zinc transporter 6

1

5

High-throughput

0.536

High

719798

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

2

High-throughput

0.536

High

719799

BRAT1
Integrator complex assembly factor BRAT1

1

2

High-throughput

0.536

High

719800

PAQR3
Progestin and adipoQ receptor family member 3

1

2

High-throughput

0.536

High

719802

CERS6
Ceramide synthase 6

1

8

High-throughput

0.536

High

719803

DYM
Dymeclin

1

5

High-throughput

0.536

High

719809

INT1
Integrator complex subunit 1

1

6

High-throughput

0.536

High

719815

ATLA2
Atlastin-2

1

6

High-throughput

0.536

High

719817

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

5

High-throughput

0.536

High

719818

GOGA5
Golgin subfamily A member 5

1

3

High-throughput

0.536

High

719819

CIP2A
Protein CIP2A

1

1

High-throughput

0.536

High

719820

SPPL3
Signal peptide peptidase-like 3

1

1

High-throughput

0.536

High

719821

CHPT1
Cholinephosphotransferase 1

1

3

High-throughput

0.536

High

719822

S35F5
Solute carrier family 35 member F5

1

3

High-throughput

0.536

High

719825

GLMN
Glomulin

1

1

High-throughput

0.536

High

719829

EXOC2
Exocyst complex component 2

1

4

High-throughput

0.536

High

719830

XPO6
Exportin-6

1

2

High-throughput

0.536

High

719832

GCP2
Gamma-tubulin complex component 2

1

8

High-throughput

0.536

High

719835

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.536

High

719837

YIPF3
Protein YIPF3

1

4

High-throughput

0.536

High

719840

ARV1
Protein ARV1

1

2

High-throughput

0.536

High

719843

GOLP3
Golgi phosphoprotein 3

1

4

High-throughput

0.536

High

719845

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.536

High

719849

SERC1
Serine incorporator 1

1

1

High-throughput

0.536

High

719850

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

1

High-throughput

0.536

High

719852

ELOV2
Very long chain fatty acid elongase 2

1

3

High-throughput

0.536

High

719853

GCP4
Gamma-tubulin complex component 4

1

8

High-throughput

0.536

High

719857

S39AA
Zinc transporter ZIP10

1

7

High-throughput

0.536

High

719859

FND3A
Fibronectin type-III domain-containing protein 3A

1

7

High-throughput

0.536

High

719834

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

1

Small-scale

0.527

High

719814

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.517

High

184389

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

719794

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.513

High

719824

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

High-throughput

0.513

High

719831

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.513

High

719841

TM245
Transmembrane protein 245

1

0

High-throughput

0.513

High

719847

JPH1
Junctophilin-1

1

0

High-throughput

0.513

High

719848

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.513

High

719772

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

2

Small-scale

0.501

High

719774

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

Small-scale

0.501

High

164534

TNPO2
Transportin-2

1

8

High-throughput

0.489

High

173663

BTAF1
TATA-binding protein-associated factor 172

1

3

High-throughput

0.489

High

187468

FANCA
Fanconi anemia group A protein

1

2

High-throughput

0.489

High

189114

IPO8
Importin-8

1

12

High-throughput

0.489

High

397787

ATP8
ATP synthase F(0) complex subunit 8

1

2

High-throughput

0.489

High

719783

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.489

High

719787

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.489

High

719789

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

1

High-throughput

0.489

High

719791

S35F1
Solute carrier family 35 member F1

1

3

High-throughput

0.489

High

719797

MZT2B
Mitotic-spindle organizing protein 2B

1

2

High-throughput

0.489

High

719801

THADA
tRNA

1

5

High-throughput

0.489

High

719804

MAVS
Mitochondrial antiviral-signaling protein

1

2

High-throughput

0.489

High

719807

DAAF5
Dynein axonemal assembly factor 5

1

2

High-throughput

0.489

High

719810

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

1

High-throughput

0.489

High

719811

MACOI
Macoilin

1

1

High-throughput

0.489

High

719812

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

1

High-throughput

0.489

High

719816

MFSD8
Major facilitator superfamily domain-containing protein 8

1

6

High-throughput

0.489

High

719823

ATRIP
ATR-interacting protein

1

1

High-throughput

0.489

High

719826

S2546
Mitochondrial outer membrane protein SLC25A46

1

3

High-throughput

0.489

High

719827

INT12
Integrator complex subunit 12

1

1

High-throughput

0.489

High

719836

XPO4
Exportin-4

1

14

High-throughput

0.489

High

719846

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

2

High-throughput

0.489

High

719854

IPO11
Importin-11

1

12

High-throughput

0.489

High

719856

XPO7
Exportin-7

1

20

High-throughput

0.489

High

377025

NEU2
Vasopressin-neurophysin 2-copeptin

1

0

Small-scale

0.480

High

169453

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

Small-scale

0.479

High

719771

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

719777

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.479

High

719833

DERL1
Derlin-1

1

1

Small-scale

0.479

High

719858

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

719838

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.460

High

229894

ATP9B
Probable phospholipid-transporting ATPase IIB

1

6

High-throughput

0.445

High

627270

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

19

High-throughput

0.445

High

664945

ERD21
ER lumen protein-retaining receptor 1

1

1

High-throughput

0.445

High

719770

SC5A3
Sodium/myo-inositol cotransporter

1

3

High-throughput

0.445

High

506561

GPHRB
Golgi pH regulator B

1

6

High-throughput

0.437

High

85340

GPHRA
Golgi pH regulator A

1

6

High-throughput

0.407

High

719839

TLRN1
Talin rod domain-containing protein 1

1

1

High-throughput

0.407

High

719851

TM160
Transmembrane protein 160

2

0

High-throughput

0.313

High

328357

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.279

Low

719779

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.279

Low

719790

SYVM
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

719793

ZMYM4
Zinc finger MYM-type protein 4

1

0

High-throughput

0.279

Low

719805

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

0

High-throughput

0.279

Low

719806

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

719828

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.279

Low

719842

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

0

High-throughput

0.279

Low

719844

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

719855

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025