Protein: HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)

Gene: HOIL1, RBCK1
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q9BYM8

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003713 - transcription coactivator activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0032088 - negative regulation of NF-kappaB transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476320

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

13

20

Small-scale

0.983

High

932567

UB2L3
Ubiquitin-conjugating enzyme E2 L3

10

20

Small-scale

0.975

High

1317075

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

5

17

Small-scale

0.927

High

895899

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.919

High

159089

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

4

20

High-throughput

0.911

High

919847

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.845

High

896367

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1290049

RNF31
E3 ubiquitin-protein ligase RNF31

34

19

Small-scale

0.771

High

1317079

SHRPN
Sharpin

15

5

Small-scale

0.762

High

1317106

NEMO
NF-kappa-B essential modulator

12

15

Small-scale

0.760

High

352698

TNFA
Tumor necrosis factor

12

4

Small-scale

0.756

High

1052761

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

16

Small-scale

0.747

High

1285698

OTUL
Ubiquitin thioesterase otulin

6

2

Small-scale

0.721

High

228595

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.698

High

585055

RO52
E3 ubiquitin-protein ligase TRIM21

1

9

High-throughput

0.698

High

896534

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

908267

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

20

High-throughput

0.698

High

1086922

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

High-throughput

0.698

High

1138917

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1162055

TRI65
E3 ubiquitin-protein ligase TRIM65

1

13

High-throughput

0.698

High

1299583

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

3

High-throughput

0.698

High

1317101

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1079015

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.691

High

408678

KPCB
Protein kinase C beta type

4

12

Small-scale

0.680

High

1317095

FKBPL
FK506-binding protein-like

3

10

Small-scale

0.679

High

1023790

TRAF1
TNF receptor-associated factor 1

3

14

Small-scale

0.674

High

738695

TNR3
Tumor necrosis factor receptor superfamily member 3

3

6

High-throughput

0.667

High

370369

ESR1
Estrogen receptor

3

7

Small-scale

0.664

High

1317085

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

7

Small-scale

0.656

High

849432

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

584467

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

5

Small-scale

0.640

High

816828

IREB2
Iron-responsive element-binding protein 2

2

2

Small-scale

0.631

High

181348

ARPC5
Actin-related protein 2/3 complex subunit 5

2

1

High-throughput

0.628

High

638390

RBTN2
Rhombotin-2

2

9

High-throughput

0.628

High

1317096

RABX5
Rab5 GDP/GTP exchange factor

2

3

High-throughput

0.628

High

1299515

TSSK3
Testis-specific serine/threonine-protein kinase 3

3

2

High-throughput

0.616

High

599724

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

9

Small-scale

0.614

High

637539

PSA1
Proteasome subunit alpha type-1

2

12

High-throughput

0.606

High

973623

CREB5
Cyclic AMP-responsive element-binding protein 5

2

8

High-throughput

0.606

High

1047706

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

10

High-throughput

0.606

High

1252454

LNX1
E3 ubiquitin-protein ligase LNX

2

8

High-throughput

0.606

High

1038316

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

13

Small-scale

0.601

High

1317103

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.601

High

874168

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

1

Small-scale

0.595

High

1317093

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

5

Small-scale

0.595

High

330282

BCL10
B-cell lymphoma/leukemia 10

2

1

Small-scale

0.584

High

1025545

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

13

Small-scale

0.584

High

1217853

GLCTK
Glycerate kinase

2

0

High-throughput

0.580

High

1294612

ZN414
Zinc finger protein 414

2

0

High-throughput

0.580

High

782290

NAA10
N-alpha-acetyltransferase 10

1

3

High-throughput

0.573

High

157239

BACH1
Transcription regulator protein BACH1

1

18

Small-scale

0.561

High

387449

P53
Cellular tumor antigen p53

1

7

Small-scale

0.561

High

566475

KPCA
Protein kinase C alpha type

1

13

Small-scale

0.561

High

978884

TF65
Transcription factor p65

1

6

Small-scale

0.561

High

231835

MABP1
Mitogen-activated protein kinase-binding protein 1

2

14

High-throughput

0.553

High

678969

HXC8
Homeobox protein Hox-C8

2

6

High-throughput

0.553

High

1144769

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

6

High-throughput

0.553

High

1171574

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

718425

PCGF2
Polycomb group RING finger protein 2

1

5

High-throughput

0.541

High

1238747

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

8

High-throughput

0.541

High

1317078

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

6

High-throughput

0.541

High

1317091

RN181
E3 ubiquitin-protein ligase RNF181

1

2

High-throughput

0.541

High

275509

CAN15
Calpain-15

1

20

High-throughput

0.536

High

302203

AP2A2
AP-2 complex subunit alpha-2

1

6

High-throughput

0.536

High

335310

DYR
Dihydrofolate reductase

1

2

High-throughput

0.536

High

845707

RAB9A
Ras-related protein Rab-9A

1

7

High-throughput

0.536

High

906787

NCS1
Neuronal calcium sensor 1

1

2

High-throughput

0.536

High

1036047

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

Small-scale

0.536

High

1064115

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.536

High

1119048

AMOT
Angiomotin

1

13

High-throughput

0.536

High

1138856

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.536

High

1161519

ULK3
Serine/threonine-protein kinase ULK3

1

5

High-throughput

0.536

High

1205693

PDPN
Podoplanin

1

1

High-throughput

0.536

High

1220110

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

10

High-throughput

0.536

High

1245169

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.536

High

1261196

ZFN2B
AN1-type zinc finger protein 2B

1

2

High-throughput

0.536

High

1284797

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1317104

RN115
E3 ubiquitin-protein ligase RNF115

1

5

High-throughput

0.536

High

72159

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

265880

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

10

Small-scale

0.523

High

201424

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

Small-scale

0.515

High

1234339

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

14

Small-scale

0.515

High

1317090

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

9

Small-scale

0.515

High

868720

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1312981

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.513

High

1317089

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

0

High-throughput

0.513

High

1231443

ANR35
Ankyrin repeat domain-containing protein 35

1

7

Small-scale

0.512

High

200939

MTSS1
Protein MTSS 1

1

5

Small-scale

0.504

High

829995

HXA1
Homeobox protein Hox-A1

1

7

Small-scale

0.504

High

395695

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

808256

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

8

High-throughput

0.501

High

1028427

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

11

Small-scale

0.501

High

1317086

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

Small-scale

0.501

High

883126

DSCR6
Protein ripply3

1

1

High-throughput

0.494

High

1317084

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

8

High-throughput

0.494

High

87313

UMAD1
UBAP1-MVB12-associated

1

1

High-throughput

0.489

High

165321

KHNYN
Protein KHNYN

1

1

High-throughput

0.489

High

441634

TRFM
Melanotransferrin

1

1

High-throughput

0.489

High

653101

CD82
CD82 antigen

1

2

High-throughput

0.489

High

946434

EREP3
Protein ENTREP3

1

2

High-throughput

0.489

High

1165079

MOXD1
DBH-like monooxygenase protein 1

1

1

High-throughput

0.489

High

1204887

VP37D
Vacuolar protein sorting-associated protein 37D

1

2

High-throughput

0.489

High

1241915

ARRD4
Arrestin domain-containing protein 4

1

5

High-throughput

0.489

High

1317076

ULBP3
UL16-binding protein 3

1

3

High-throughput

0.489

High

1317092

TEN3
Teneurin-3

1

4

High-throughput

0.489

High

160178

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

8

High-throughput

0.481

High

271185

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

18

High-throughput

0.481

High

1119479

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

13

High-throughput

0.481

High

1244176

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

18

High-throughput

0.481

High

1273850

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.481

High

1288089

OTUB2
Ubiquitin thioesterase OTUB2

1

2

High-throughput

0.481

High

1317082

ANTR1
Anthrax toxin receptor 1

1

6

Small-scale

0.481

High

1317098

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

High-throughput

0.481

High

1317102

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

High-throughput

0.481

High

1317105

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

High-throughput

0.481

High

179959

TLR3
Toll-like receptor 3

1

7

Small-scale

0.479

High

321930

RIGI
Antiviral innate immune response receptor RIG-I

1

16

Small-scale

0.479

High

432233

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

506044

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

5

Small-scale

0.479

High

596097

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

Small-scale

0.479

High

658429

DPOD1
DNA polymerase delta catalytic subunit

1

4

Small-scale

0.479

High

667486

CASP1
Caspase-1

1

5

Small-scale

0.479

High

788905

RS27
Small ribosomal subunit protein eS27

1

2

Small-scale

0.479

High

808895

YAP1
Transcriptional coactivator YAP1

1

13

Small-scale

0.479

High

890835

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

893742

PSA6
Proteasome subunit alpha type-6

1

13

Small-scale

0.479

High

899561

MGN
Protein mago nashi homolog

1

1

Small-scale

0.479

High

1042467

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1056462

IRF3
Interferon regulatory factor 3

1

4

Small-scale

0.479

High

1078489

TOM34
Mitochondrial import receptor subunit TOM34

1

17

Small-scale

0.479

High

1242643

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

10

Small-scale

0.479

High

1312799

TBB6
Tubulin beta-6 chain

1

15

Small-scale

0.479

High

1315462

CAR11
Caspase recruitment domain-containing protein 11

1

6

Small-scale

0.479

High

1317081

ZBP1
Z-DNA-binding protein 1

1

1

Small-scale

0.479

High

1317087

PDLI7
PDZ and LIM domain protein 7

1

17

Small-scale

0.479

High

1317088

PICK1
PRKCA-binding protein

1

1

Small-scale

0.479

High

1317094

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1317099

AGO2
Protein argonaute-2

1

4

Small-scale

0.479

High

1317100

SPAT2
Spermatogenesis-associated protein 2

1

2

Small-scale

0.479

High

1025948

TADBP
TAR DNA-binding protein 43

1

16

High-throughput

0.470

High

3258

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

10

High-throughput

0.457

High

1173828

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

13

High-throughput

0.439

High

1185437

OTU6A
OTU domain-containing protein 6A

1

2

High-throughput

0.439

High

171168

CETN3
Centrin-3

1

3

Small-scale

0.437

High

469889

CO4A
Complement C4-A

1

3

Small-scale

0.437

High

591406

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

6

Small-scale

0.437

High

726395

BASI
Basigin

1

7

Small-scale

0.437

High

824356

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

Small-scale

0.437

High

858319

TXTP
Tricarboxylate transport protein, mitochondrial

1

10

Small-scale

0.437

High

1055159

HLTF
Helicase-like transcription factor

1

6

Small-scale

0.437

High

1317077

FHDC1
FH2 domain-containing protein 1

1

3

Small-scale

0.437

High

1317097

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

8

Small-scale

0.437

High

170565

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

0

High-throughput

0.347

High

1140018

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1317080

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1229568

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.299

High

1312564

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.299

High

275101

RENR
Renin receptor

1

0

High-throughput

0.279

Low

1083244

CART

1

0

High-throughput

0.279

Low

1317083

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.279

Low

857507

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.249

Low

1264533

SSH1
Protein phosphatase Slingshot homolog 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024