Protein: UBE4A
Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)

Gene: UBE4A
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q14139

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906664

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.800

High

957078

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

1121132

UBXN4
UBX domain-containing protein 4

5

3

High-throughput

0.718

High

982185

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1121158

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

934592

TERA
Transitional endoplasmic reticulum ATPase

3

9

High-throughput

0.650

High

1121131

IP6K1
Inositol hexakisphosphate kinase 1

3

0

High-throughput

0.632

High

289147

PRDM1
PR domain zinc finger protein 1

2

8

High-throughput

0.628

High

641172

FGFR2
Fibroblast growth factor receptor 2

2

5

High-throughput

0.628

High

1121121

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

2

High-throughput

0.604

High

1121119

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.586

High

951142

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.585

High

438077

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

1121120

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

1

High-throughput

0.574

High

1098884

SLAP1
Src-like-adapter

1

5

Small-scale

0.561

High

332997

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

0

High-throughput

0.547

High

1121107

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

0

Small-scale

0.537

High

945700

FOXL2
Forkhead box protein L2

1

4

High-throughput

0.536

High

1091276

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.536

High

1121117

FOXI2
Forkhead box protein I2

1

4

High-throughput

0.536

High

1121138

SPSB4
SPRY domain-containing SOCS box protein 4

1

3

High-throughput

0.536

High

1121142

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

1121144

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.536

High

1121125

SH2D3
SH2 domain-containing protein 3C

2

5

High-throughput

0.521

High

1121141

CLIC6
Chloride intracellular channel protein 6

1

0

High-throughput

0.518

High

277356

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.515

High

351385

CBX7
Chromobox protein homolog 7

1

0

High-throughput

0.513

High

1022851

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1121143

SELS
Selenoprotein S

1

0

High-throughput

0.513

High

518745

GRAB
Granzyme B

1

4

Small-scale

0.501

High

937000

CASP6
Caspase-6

1

2

Small-scale

0.501

High

1121154

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.493

High

388126

ACHA
Acetylcholine receptor subunit alpha

1

1

High-throughput

0.489

High

388191

GLPA
Glycophorin-A

1

1

High-throughput

0.489

High

595045

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.489

High

1101483

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.489

High

1121108

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1121139

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

353812

PTTG1
Securin

1

0

Small-scale

0.480

High

408865

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.479

High

413813

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

611114

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

1004551

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1028196

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1088835

TP53B
TP53-binding protein 1

1

1

Small-scale

0.479

High

1106531

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

1106846

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1121109

PCBP1
Poly(rC)-binding protein 1

1

1

Small-scale

0.479

High

1121118

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1121122

GOLI
E3 ubiquitin-protein ligase RNF130

1

5

High-throughput

0.479

High

1121128

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1121133

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1121135

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1121136

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1121137

CUL5
Cullin-5

1

2

High-throughput

0.479

High

1121156

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

698648

CALX
Calnexin

1

0

High-throughput

0.458

High

1102533

MTA1
Metastasis-associated protein MTA1

1

0

Small-scale

0.458

High

1121153

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1121155

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

710237

EPHA2
Ephrin type-A receptor 2

1

5

Small-scale

0.457

High

166298

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

613350

VINC
Vinculin

1

2

High-throughput

0.445

High

1121112

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1121134

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

1121152

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

411909

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

611729

BMP7
Bone morphogenetic protein 7

1

2

Small-scale

0.437

High

1029428

IL9R
Interleukin-9 receptor

1

2

High-throughput

0.437

High

1121140

DNJC1
DnaJ homolog subfamily C member 1

1

12

High-throughput

0.437

High

48238

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.426

High

219438

S26A4
Pendrin

1

1

High-throughput

0.407

High

437675

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

466893

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.407

High

1121113

ANR22
Ankyrin repeat domain-containing protein 22

1

3

High-throughput

0.407

High

1121114

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1121115

S27A4
Long-chain fatty acid transport protein 4

1

4

High-throughput

0.407

High

1121116

S27A1
Long-chain fatty acid transport protein 1

1

4

High-throughput

0.407

High

251084

B4GT3
Beta-1,4-galactosyltransferase 3

3

0

High-throughput

0.347

High

1121126

PAR16
Protein mono-ADP-ribosyltransferase PARP16

3

0

High-throughput

0.347

High

749203

CD70
CD70 antigen

2

0

High-throughput

0.328

High

1121110

SV2C
Synaptic vesicle glycoprotein 2C

2

0

High-throughput

0.328

High

1121127

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

1121129

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.301

High

822

A0A096LNW4
PRAME family member 9

1

0

High-throughput

0.279

Low

71207

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

850774

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

0

High-throughput

0.279

Low

931359

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.279

Low

1121111

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1121123

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

1121124

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1121145

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1121146

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

1121147

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1121148

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1121149

TM134
Transmembrane protein 134

1

0

High-throughput

0.279

Low

1121150

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

1121157

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

105915

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

993073

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1121130

FAM3C
Protein FAM3C

1

0

Small-scale

0.249

Low

1121151

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

50551

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025