Protein: AMPL
Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase)

Gene: AMPL, LAP3
Organism: Homo sapiens
Interactions: 71
UniProt ID: P28838

Gene Ontology (top 5):
GO:0004177 - aminopeptidase activity
GO:0004180 - carboxypeptidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

240830

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

648328

USF1
Upstream stimulatory factor 1

2

2

High-throughput

0.606

High

705805

CBX5
Chromobox protein homolog 5

2

1

High-throughput

0.606

High

705814

CBX3
Chromobox protein homolog 3

2

1

High-throughput

0.606

High

705849

MARE3
Microtubule-associated protein RP/EB family member 3

2

1

High-throughput

0.606

High

705804

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

705822

ZYX
Zyxin

2

0

High-throughput

0.580

High

705829

BANP
Protein BANP

2

0

High-throughput

0.580

High

705832

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.580

High

705807

DNLI4
DNA ligase 4

1

1

High-throughput

0.552

High

705812

KPCE
Protein kinase C epsilon type

2

0

High-throughput

0.547

High

705808

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

231205

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.513

High

651750

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.513

High

705809

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.513

High

705820

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

185447

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

421550

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

371244

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

473808

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

685412

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

705826

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

705827

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.479

High

705835

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

705851

RPGF2
Rap guanine nucleotide exchange factor 2

1

1

High-throughput

0.479

High

227390

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

319433

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

411416

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

425335

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.458

High

536564

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

550862

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

705810

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

705811

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

705815

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

705817

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

705818

CUL3
Cullin-3

1

0

High-throughput

0.458

High

705821

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

705824

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

705830

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

705833

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

705836

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

705840

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.458

High

705843

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

705846

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

705847

TES
Testin

1

0

High-throughput

0.458

High

529151

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

705850

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

705813

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

0

Small-scale

0.438

High

705837

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

705848

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

0

Small-scale

0.438

High

409275

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

429359

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

653144

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

705816

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

705823

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

705842

S2532
Solute carrier family 25 member 32

1

0

High-throughput

0.426

High

705845

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

705825

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

705834

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.316

High

705819

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

705828

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

705838

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

705844

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.279

Low

705852

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.279

Low

105399

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

705803

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

705806

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

705831

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

261092

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

705839

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

705841

CAD23
Cadherin-23

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025