Protein: HPT
Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]

Gene: HPT, HP
Organism: Homo sapiens
Interactions: 99
UniProt ID: P00738

Gene Ontology (top 5):
GO:0002376 - immune system process
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006952 - defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341199

HBB
Hemoglobin subunit beta

2

1

Small-scale

0.754

High

126316

MATN2
Matrilin-2

1

10

High-throughput

0.691

High

198325

KLK10
Kallikrein-10

1

13

High-throughput

0.691

High

341169

HPTR
Haptoglobin-related protein

1

12

High-throughput

0.691

High

341210

FBLN7
Fibulin-7

1

13

High-throughput

0.691

High

341233

EGFL8
Epidermal growth factor-like protein 8

1

13

High-throughput

0.691

High

341198

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.656

High

341172

APOA1
Apolipoprotein A-I

3

1

Small-scale

0.651

High

341170

A1AT
Alpha-1-antitrypsin

1

20

High-throughput

0.618

High

341171

AACT
Alpha-1-antichymotrypsin

1

20

High-throughput

0.618

High

341174

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

9

High-throughput

0.618

High

341175

FIBG
Fibrinogen gamma chain

1

9

High-throughput

0.618

High

341251

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

341173

APOE
Apolipoprotein E

1

1

Small-scale

0.589

High

341207

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.574

High

341230

SNX27
Sorting nexin-27

2

2

High-throughput

0.574

High

341177

ALBU
Albumin

1

6

High-throughput

0.536

High

341209

FNDC1
Fibronectin type III domain-containing protein 1

1

6

High-throughput

0.536

High

341219

FNDC5
Fibronectin type III domain-containing protein 5

1

7

High-throughput

0.536

High

341243

NGB
Neuroglobin

1

0

High-throughput

0.517

High

328074

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

341202

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.513

High

341221

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

341244

NOX4
NADPH oxidase 4

1

0

High-throughput

0.513

High

341182

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.501

High

341224

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

127083

FOXN3
Forkhead box protein N3

1

2

High-throughput

0.489

High

182991

P2RX6
P2X purinoceptor 6

1

3

High-throughput

0.489

High

297216

DDHD2
Phospholipase DDHD2

1

1

High-throughput

0.489

High

331680

NSD2
Histone-lysine N-methyltransferase NSD2

1

3

High-throughput

0.489

High

341190

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

341193

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.489

High

341201

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.489

High

341211

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

341213

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

341222

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

341226

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

5

High-throughput

0.489

High

341227

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

341232

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

341249

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

341250

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

341253

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

126894

WASL
Actin nucleation-promoting factor WASL

1

2

High-throughput

0.481

High

341254

LAMC3
Laminin subunit gamma-3

1

7

High-throughput

0.481

High

336748

CERU
Ceruloplasmin

1

5

High-throughput

0.479

High

341178

VTDB
Vitamin D-binding protein

1

6

High-throughput

0.479

High

341179

TRFE
Serotransferrin

1

1

High-throughput

0.479

High

341180

HEMO
Hemopexin

1

1

High-throughput

0.479

High

341185

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

341187

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

High-throughput

0.479

High

341189

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

341214

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

1

High-throughput

0.464

High

341186

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

341197

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.460

High

341205

MVP
Major vault protein

1

0

High-throughput

0.460

High

341176

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

341181

STAT
Statherin

1

0

High-throughput

0.458

High

341184

CLUS
Clusterin

1

0

High-throughput

0.458

High

341188

LCN1
Lipocalin-1

1

0

High-throughput

0.458

High

341206

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

341183

TAU
Microtubule-associated protein tau

1

5

Small-scale

0.445

High

341203

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.445

High

309822

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.439

High

341191

ATP7B
Copper-transporting ATPase 2

1

1

Small-scale

0.439

High

341200

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.439

High

341235

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

4

Small-scale

0.439

High

341238

P63
Tumor protein 63

1

2

High-throughput

0.439

High

341192

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.437

High

341196

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

341204

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.437

High

341215

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

2

Small-scale

0.437

High

341220

FBX22
F-box only protein 22

1

2

High-throughput

0.437

High

341223

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

341236

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

341248

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.437

High

341195

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

341216

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.407

High

341212

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

341218

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.347

High

341239

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

217688

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.279

Low

239681

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

341194

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

341208

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

341217

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

0

High-throughput

0.279

Low

341225

PMEPA
Protein TMEPAI

1

0

High-throughput

0.279

Low

341228

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

341229

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.279

Low

341231

SORT
Sortilin

1

0

High-throughput

0.279

Low

341234

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.279

Low

341240

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.279

Low

341241

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

341242

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.279

Low

341245

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

341246

PLS4
Phospholipid scramblase 4

1

0

High-throughput

0.279

Low

341252

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

Small-scale

0.278

Low

341237

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

245551

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.251

Low

341247

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024