Protein: UBA5
Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)

Gene: UBA5
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9GZZ9

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952335

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

9

20

High-throughput

0.980

High

964551

UFM1
Ubiquitin-fold modifier 1

10

2

Small-scale

0.976

High

1429199

UBA5
Ubiquitin-like modifier-activating enzyme 5

3

13

Small-scale

0.805

High

1429200

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

20

High-throughput

0.777

High

1429217

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

6

1

Small-scale

0.736

High

328145

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.681

High

1417410

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

20

High-throughput

0.681

High

1428343

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.681

High

1294644

CD20B
Cell division cycle protein 20 homolog B

3

2

High-throughput

0.667

High

1336470

PNMA1
Paraneoplastic antigen Ma1

3

1

High-throughput

0.667

High

1402175

PRPK
EKC/KEOPS complex subunit TP53RK

3

2

High-throughput

0.662

High

957666

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

19

Small-scale

0.647

High

982316

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

16

High-throughput

0.647

High

996017

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.647

High

1332304

BOLL
Protein boule-like

3

0

High-throughput

0.638

High

1417770

PECR
Peroxisomal trans-2-enoyl-CoA reductase

3

0

High-throughput

0.638

High

1141475

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

3

0

High-throughput

0.634

High

1429219

VATD
V-type proton ATPase subunit D

3

0

High-throughput

0.634

High

1065024

FGL1
Fibrinogen-like protein 1

4

1

High-throughput

0.630

High

156338

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

2

1

High-throughput

0.628

High

1123226

DPYL1
Dihydropyrimidinase-related protein 1

2

2

High-throughput

0.628

High

1429208

KLHL8
Kelch-like protein 8

2

1

High-throughput

0.628

High

1394143

REXO5
RNA exonuclease 5

2

0

High-throughput

0.602

High

568345

ACPH
Acylamino-acid-releasing enzyme

1

1

High-throughput

0.541

High

365464

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.536

High

489059

LKHA4
Leukotriene A-4 hydrolase

1

2

High-throughput

0.536

High

567074

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.536

High

573661

ENPL
Endoplasmin

1

7

High-throughput

0.536

High

592898

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.536

High

603360

KPCA
Protein kinase C alpha type

1

3

High-throughput

0.536

High

687724

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

2

High-throughput

0.536

High

716621

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

4

High-throughput

0.536

High

761021

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.536

High

881302

FAS
Fatty acid synthase

1

1

High-throughput

0.536

High

883144

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

High-throughput

0.536

High

884790

SYSC
Serine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

888319

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.536

High

906449

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.536

High

963015

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.536

High

985553

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.536

High

1007850

GSTO1
Glutathione S-transferase omega-1

1

3

High-throughput

0.536

High

1038699

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

6

High-throughput

0.536

High

1098130

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.536

High

1131383

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.536

High

1217913

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

1

High-throughput

0.536

High

1242576

MZT2A
Mitotic-spindle organizing protein 2A

1

2

High-throughput

0.536

High

1270417

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.536

High

1356994

PDC6I
Programmed cell death 6-interacting protein

1

2

High-throughput

0.536

High

1396124

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.536

High

1402514

NEB2
Neurabin-2

1

4

High-throughput

0.536

High

1413610

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

4

High-throughput

0.536

High

1429205

SHLB2
Endophilin-B2

1

1

High-throughput

0.536

High

1429213

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.536

High

1429218

IPP
Actin-binding protein IPP

1

1

High-throughput

0.536

High

226995

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

261441

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

0

High-throughput

0.513

High

343468

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.513

High

599879

YBOX3
Y-box-binding protein 3

1

0

High-throughput

0.513

High

773631

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.513

High

786351

PGM1
Phosphoglucomutase-1

1

0

High-throughput

0.513

High

911673

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.513

High

970095

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

983342

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

1111254

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1116911

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.513

High

1121873

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

High-throughput

0.513

High

1149063

CYH1
Cytohesin-1

1

0

High-throughput

0.513

High

1154735

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.513

High

1164014

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1360471

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1368951

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.513

High

1369380

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

High-throughput

0.513

High

1404377

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1412232

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

1429201

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1429202

JUPI2
Jupiter microtubule associated homolog 2

1

0

High-throughput

0.513

High

1429203

SFXN1
Sideroflexin-1

1

0

High-throughput

0.513

High

1429210

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.513

High

186007

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

706301

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

123180

DX39A
ATP-dependent RNA helicase DDX39A

1

2

High-throughput

0.479

High

173331

XPO1
Exportin-1

1

2

High-throughput

0.479

High

731600

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

935109

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

1067696

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1158994

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.479

High

1255458

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1334896

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1367221

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1416877

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

6

High-throughput

0.479

High

1429209

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1429211

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1429212

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

705840

AMPL
Cytosol aminopeptidase

1

0

High-throughput

0.458

High

1429207

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.458

High

1209635

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1314408

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.445

High

1429214

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

717151

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.437

High

1129270

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.426

High

1332763

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.426

High

1429204

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.426

High

1429216

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

High-throughput

0.426

High

1327364

MREG
Melanoregulin

3

0

High-throughput

0.347

High

423939

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

568494

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1158827

CART

1

0

High-throughput

0.279

Low

1416840

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

0

High-throughput

0.279

Low

1429206

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.279

Low

1429215

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1135506

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025