Protein: TGS1
Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)

Gene: TGS1
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q96RS0

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974020

RUXF
Small nuclear ribonucleoprotein F

4

1

High-throughput

0.697

High

643999

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

Small-scale

0.688

High

485715

RU2A
U2 small nuclear ribonucleoprotein A'

4

0

High-throughput

0.661

High

1130592

NCOA6
Nuclear receptor coactivator 6

3

0

Small-scale

0.650

High

1401850

NOP58
Nucleolar protein 58

2

1

Small-scale

0.639

High

973800

RUXE
Small nuclear ribonucleoprotein E

3

0

High-throughput

0.634

High

574435

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.628

High

991230

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

2

High-throughput

0.628

High

1067622

EP300
Histone acetyltransferase p300

2

1

Small-scale

0.624

High

1401839

TGS1
Trimethylguanosine synthase

1

1

Small-scale

0.621

High

974185

RUXG
Small nuclear ribonucleoprotein G

2

4

High-throughput

0.611

High

1194304

LARP7
La-related protein 7

2

1

High-throughput

0.611

High

472999

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

0

High-throughput

0.602

High

480277

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.602

High

471906

RU2B
U2 small nuclear ribonucleoprotein B''

2

1

High-throughput

0.601

High

173254

XPO1
Exportin-1

2

2

Small-scale

0.595

High

783744

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

1288880

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.580

High

911349

IMA5
Importin subunit alpha-5

2

0

High-throughput

0.576

High

800062

COIL
Coilin

2

0

High-throughput

0.575

High

1151284

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.561

High

1368457

CBP
CREB-binding protein

1

1

Small-scale

0.561

High

431224

LA
Lupus La protein

1

1

High-throughput

0.536

High

478171

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

556947

MYH7
Myosin-7

1

1

High-throughput

0.536

High

974821

SMD3
Small nuclear ribonucleoprotein Sm D3

1

2

High-throughput

0.536

High

1137001

SEPT2
Septin-2

1

3

High-throughput

0.536

High

1151498

IKBB
NF-kappa-B inhibitor beta

1

1

High-throughput

0.536

High

1156410

SEPT7
Septin-7

1

3

High-throughput

0.536

High

1380459

LSM10
U7 snRNA-associated Sm-like protein LSm10

1

2

High-throughput

0.536

High

1401852

MYH4
Myosin-4

1

1

High-throughput

0.536

High

177296

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.518

High

564250

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

212783

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.513

High

228742

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

0

High-throughput

0.513

High

609889

IBP3
Insulin-like growth factor-binding protein 3

1

0

High-throughput

0.513

High

704757

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.513

High

791645

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

974646

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1013497

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

0

High-throughput

0.513

High

1122319

SCRIB
Protein scribble homolog

1

0

High-throughput

0.513

High

1157671

CRY1
Cryptochrome-1

1

0

High-throughput

0.513

High

1210737

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.513

High

1281451

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1314212

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

0

High-throughput

0.513

High

1397236

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1401840

SRBS1
Sorbin and SH3 domain-containing protein 1

1

0

High-throughput

0.513

High

1401845

DNJB4
DnaJ homolog subfamily B member 4

1

0

High-throughput

0.513

High

1401848

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.513

High

1401849

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.513

High

285424

EED
Polycomb protein EED

1

0

Small-scale

0.504

High

1110851

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

0

High-throughput

0.493

High

834037

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

Small-scale

0.480

High

1394551

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.479

High

1401847

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1255161

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1401841

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1401842

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.458

High

1401843

DCA13
DDB1- and CUL4-associated factor 13

1

0

Small-scale

0.458

High

1401846

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

96006

E7EW69
Septin

1

3

High-throughput

0.445

High

1150799

SF01
Splicing factor 1

1

0

High-throughput

0.438

High

1310330

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

1401844

SEP10
Septin-10

1

3

High-throughput

0.437

High

71607

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

4

High-throughput

0.407

High

116553

H7C5Q0
Arginine and serine rich coiled-coil 1

1

1

High-throughput

0.407

High

1322713

F177A
Protein FAM177A1

3

0

High-throughput

0.347

High

207866

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

706273

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1098221

MYBPH
Myosin-binding protein H

1

0

High-throughput

0.279

Low

1315405

TEFF1
Tomoregulin-1

1

0

High-throughput

0.279

Low

1401851

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025