Protein: FANCA
Fanconi anemia group A protein (Protein FACA)

Gene: FANCA
Organism: Homo sapiens
Interactions: 183
UniProt ID: O15360

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

185126

FANCG
Fanconi anemia group G protein

54

2

Small-scale

0.772

High

187533

FANCM
Fanconi anemia group M protein

12

1

Small-scale

0.756

High

187499

FANCC
Fanconi anemia group C protein

33

0

Small-scale

0.736

High

187563

FANCF
Fanconi anemia group F protein

23

0

Small-scale

0.733

High

187561

FANCE
Fanconi anemia group E protein

15

0

Small-scale

0.727

High

187568

FANCL
E3 ubiquitin-protein ligase FANCL

15

0

Small-scale

0.727

High

187527

FAP20
Fanconi anemia core complex-associated protein 20

11

0

Small-scale

0.727

High

187538

FANCB
Fanconi anemia group B protein

7

0

Small-scale

0.714

High

187420

FANCA
Fanconi anemia group A protein

8

0

Small-scale

0.709

High

187506

FP100
Fanconi anemia core complex-associated protein 100

5

0

Small-scale

0.684

High

187491

BLM
RecQ-like DNA helicase BLM

5

0

Small-scale

0.678

High

187511

TOP3A
DNA topoisomerase 3-alpha

5

0

Small-scale

0.676

High

187479

BRCA1
Breast cancer type 1 susceptibility protein

3

0

Small-scale

0.654

High

187465

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

0

Small-scale

0.648

High

187514

SPTN1
Spectrin alpha chain, non-erythrocytic 1

3

1

Small-scale

0.643

High

187552

FAP24
Fanconi anemia core complex-associated protein 24

3

0

Small-scale

0.628

High

187469

AKT1
RAC-alpha serine/threonine-protein kinase

2

1

Small-scale

0.625

High

70856

CENPX
Centromere protein X

3

0

Small-scale

0.613

High

187535

CENPS
Centromere protein S

3

0

Small-scale

0.613

High

187554

FACD2
Fanconi anemia group D2 protein

3

0

Small-scale

0.613

High

167769

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.608

High

177739

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

2

Small-scale

0.606

High

187489

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

0

Small-scale

0.606

High

187461

FPR1
fMet-Leu-Phe receptor

2

5

High-throughput

0.601

High

187493

CXCR4
C-X-C chemokine receptor type 4

2

6

High-throughput

0.601

High

187510

CTBP1
C-terminal-binding protein 1

2

0

Small-scale

0.593

High

187517

HES1
Transcription factor HES-1

2

0

Small-scale

0.593

High

187532

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

3

6

High-throughput

0.593

High

187445

HS90A
Heat shock protein HSP 90-alpha

2

2

Small-scale

0.586

High

187436

SPTA1
Spectrin alpha chain, erythrocytic 1

2

2

Small-scale

0.584

High

187508

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.578

High

187474

OPRM
Mu-type opioid receptor

2

3

High-throughput

0.574

High

187475

APJ
Apelin receptor

2

4

High-throughput

0.574

High

187486

NPY2R
Neuropeptide Y receptor type 2

2

2

High-throughput

0.574

High

187490

NEK2
Serine/threonine-protein kinase Nek2

1

2

Small-scale

0.573

High

169824

AURKA
Aurora kinase A

1

1

Small-scale

0.561

High

187440

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.559

High

187473

CTNB1
Catenin beta-1

2

0

Small-scale

0.559

High

187560

RMI1
RecQ-mediated genome instability protein 1

2

0

Small-scale

0.559

High

187500

CENPE
Centromere-associated protein E

1

0

Small-scale

0.549

High

182413

GP182
G-protein coupled receptor 182

2

6

High-throughput

0.549

High

187509

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

6

High-throughput

0.549

High

187584

NPTN
Neuroplastin

2

1

High-throughput

0.549

High

187478

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

187444

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.529

High

187581

SNX5
Sorting nexin-5

1

0

Small-scale

0.529

High

158381

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

187432

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

187501

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.513

High

187518

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.513

High

187521

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

187526

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

187528

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

187544

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

187547

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

187551

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

187555

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

187556

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

187580

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

133217

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.489

High

187468

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.489

High

187549

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

187557

DNAI2
Dynein axonemal intermediate chain 2

1

1

High-throughput

0.489

High

187577

GPR55
G-protein coupled receptor 55

1

8

High-throughput

0.489

High

187583

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

122890

SGK1
Serine/threonine-protein kinase Sgk1

1

1

Small-scale

0.481

High

187458

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.481

High

187487

TCPG
T-complex protein 1 subunit gamma

1

1

Small-scale

0.481

High

168588

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.480

High

187512

ATR
Serine/threonine-protein kinase ATR

1

0

Small-scale

0.480

High

187421

MSH5
MutS protein homolog 5

1

1

Small-scale

0.479

High

187423

XRCC3
DNA repair protein XRCC3

1

2

Small-scale

0.479

High

187428

RA51D
DNA repair protein RAD51 homolog 4

1

2

Small-scale

0.479

High

187439

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

187447

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.479

High

187451

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

High-throughput

0.479

High

187453

ENPL
Endoplasmin

1

2

Small-scale

0.479

High

187455

NCK1
SH2/SH3 adapter protein NCK1

1

4

High-throughput

0.479

High

187471

MCM5
DNA replication licensing factor MCM5

1

1

Small-scale

0.479

High

187472

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

187481

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

187483

CRK
Adapter molecule crk

1

3

High-throughput

0.479

High

187496

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.479

High

187503

RAD51
DNA repair protein RAD51 homolog 1

1

2

Small-scale

0.479

High

187537

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

Small-scale

0.479

High

187542

XPF
DNA repair endonuclease XPF

1

1

Small-scale

0.479

High

187558

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

163662

TCRG1
Transcription elongation regulator 1

1

0

Small-scale

0.460

High

166726

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

0

Small-scale

0.460

High

171797

AZIN1
Antizyme inhibitor 1

1

0

Small-scale

0.460

High

187433

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

Small-scale

0.460

High

187437

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.460

High

187438

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.460

High

187441

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

Small-scale

0.460

High

187442

ENOA
Alpha-enolase

1

0

Small-scale

0.460

High

187452

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

187457

ZNF24
Zinc finger protein 24

1

0

Small-scale

0.460

High

187460

MX1
Interferon-induced GTP-binding protein Mx1

1

0

Small-scale

0.460

High

187464

DNJB1
DnaJ homolog subfamily B member 1

1

0

Small-scale

0.460

High

187467

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.460

High

187482

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

Small-scale

0.460

High

187495

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

Small-scale

0.460

High

187504

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.460

High

187507

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.460

High

187515

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.460

High

187541

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

Small-scale

0.460

High

187553

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

0

Small-scale

0.460

High

187571

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.460

High

187579

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.460

High

128628

MEN1
Menin

1

0

Small-scale

0.458

High

187422

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

187425

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.458

High

187426

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.458

High

187427

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

187429

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

187430

REC8
Meiotic recombination protein REC8 homolog

1

0

Small-scale

0.458

High

187443

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

187448

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

187450

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

187454

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

187456

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

187459

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.458

High

187462

TBG1
Tubulin gamma-1 chain

1

0

Small-scale

0.458

High

187466

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.458

High

187477

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

187484

NOTC1
Neurogenic locus notch homolog protein 1

1

0

Small-scale

0.458

High

187485

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

0

Small-scale

0.458

High

187492

PER3
Period circadian protein homolog 3

1

0

Small-scale

0.458

High

187494

H4
Histone H4

1

0

High-throughput

0.458

High

187497

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

187502

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.458

High

187513

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.458

High

187525

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

187529

BRAT1
Integrator complex assembly factor BRAT1

1

0

Small-scale

0.458

High

187531

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

187534

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

Small-scale

0.458

High

187539

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

Small-scale

0.458

High

187540

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

Small-scale

0.458

High

187543

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

0

Small-scale

0.458

High

187545

RMI2
RecQ-mediated genome instability protein 2

1

0

Small-scale

0.458

High

187546

DDX11
ATP-dependent DNA helicase DDX11

1

0

Small-scale

0.458

High

187550

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

187562

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

Small-scale

0.458

High

187572

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

187578

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.458

High

187424

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.445

High

187488

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.445

High

187498

BAT1
b(0,+)-type amino acid transporter 1

1

2

High-throughput

0.445

High

187476

BASI
Basigin

1

1

High-throughput

0.437

High

187585

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

Small-scale

0.437

High

166218

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

187516

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.426

High

187519

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

187574

TTC7A
Tetratricopeptide repeat protein 7A

1

0

Small-scale

0.426

High

187463

ACKR3
Atypical chemokine receptor 3

1

6

High-throughput

0.407

High

187573

LAT2
Large neutral amino acids transporter small subunit 2

1

2

High-throughput

0.407

High

187575

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.407

High

187446

ACM4
Muscarinic acetylcholine receptor M4

2

0

High-throughput

0.328

High

187523

CF118
Uncharacterized protein C6orf118

2

0

High-throughput

0.328

High

187576

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

0

High-throughput

0.313

High

187520

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

187536

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

187548

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

187559

KLK15
Kallikrein-15

1

0

High-throughput

0.279

Low

187567

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

187570

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

187431

DUS4L
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

1

0

Small-scale

0.251

Low

187449

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

Small-scale

0.251

Low

187582

LIPG
Endothelial lipase

1

0

Small-scale

0.251

Low

187530

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

139152

UPK2
Uroplakin-2

1

0

High-throughput

0.232

Low

187434

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

187435

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.232

Low

187470

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

187480

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low

187505

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low

187522

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low

187524

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

187564

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low

187565

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.232

Low

187566

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

187569

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025