Protein: GPS2
G protein pathway suppressor 2 (GPS-2)

Gene: GPS2
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q13227

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005095 - GTPase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278332

NCOR1
Nuclear receptor corepressor 1

7

2

Small-scale

0.964

High

1098614

NCOR2
Nuclear receptor corepressor 2

6

2

Small-scale

0.953

High

188263

HDAC3
Histone deacetylase 3

11

1

Small-scale

0.759

High

261404

TBL1X
F-box-like/WD repeat-containing protein TBL1X

8

2

Small-scale

0.756

High

617219

ATF4
Cyclic AMP-dependent transcription factor ATF-4

5

1

High-throughput

0.726

High

1098548

RBP1
RalA-binding protein 1

9

0

High-throughput

0.722

High

1098594

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

5

2

High-throughput

0.716

High

1017412

FOXK1
Forkhead box protein K1

4

2

High-throughput

0.699

High

225477

CYH3
Cytohesin-3

4

1

High-throughput

0.691

High

1095522

LIPA1
Liprin-alpha-1

4

1

High-throughput

0.691

High

1098549

K1H1
Keratin, type I cuticular Ha1

3

2

High-throughput

0.678

High

271622

LIPA3
Liprin-alpha-3

3

1

High-throughput

0.667

High

691728

MK03
Mitogen-activated protein kinase 3

3

1

High-throughput

0.667

High

1029670

FOXK2
Forkhead box protein K2

3

2

High-throughput

0.667

High

1098565

ANR11
Ankyrin repeat domain-containing protein 11

3

1

High-throughput

0.667

High

212659

DAPK3
Death-associated protein kinase 3

4

0

High-throughput

0.661

High

1098603

TFP11
Tuftelin-interacting protein 11

3

0

High-throughput

0.646

High

133351

DCTN6
Dynactin subunit 6

3

0

High-throughput

0.638

High

298164

DCTN3
Dynactin subunit 3

3

0

High-throughput

0.638

High

1098563

TRI68
E3 ubiquitin-protein ligase TRIM68

3

0

High-throughput

0.638

High

1098574

ARMC8
Armadillo repeat-containing protein 8

3

0

High-throughput

0.638

High

1098575

GID4
Glucose-induced degradation protein 4 homolog

3

0

High-throughput

0.638

High

1098601

ARP10
Actin-related protein 10

3

0

High-throughput

0.638

High

1098590

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

2

High-throughput

0.628

High

1098568

MAEA
E3 ubiquitin-protein transferase MAEA

2

3

High-throughput

0.611

High

1098600

GID8
Glucose-induced degradation protein 8 homolog

2

3

High-throughput

0.611

High

63192

VP37C
Vacuolar protein sorting-associated protein 37C

2

1

High-throughput

0.606

High

300349

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.606

High

300568

KRT36
Keratin, type I cuticular Ha6

2

3

High-throughput

0.606

High

1098570

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.606

High

1098592

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.606

High

1098593

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.606

High

1098612

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

1

High-throughput

0.606

High

1098541

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.586

High

191260

MSH4
MutS protein homolog 4

1

1

Small-scale

0.586

High

210455

MSH5
MutS protein homolog 5

1

1

Small-scale

0.586

High

593098

CREB1
Cyclic AMP-responsive element-binding protein 1

2

0

High-throughput

0.585

High

1098608

DCTN4
Dynactin subunit 4

2

0

High-throughput

0.585

High

1098609

MKLN1
Muskelin

2

0

High-throughput

0.585

High

473965

NFIC
Nuclear factor 1 C-type

2

3

High-throughput

0.584

High

833934

HNF4A
Hepatocyte nuclear factor 4-alpha

2

1

Small-scale

0.584

High

1087721

NFIA
Nuclear factor 1 A-type

2

4

High-throughput

0.584

High

1098611

HDAC5
Histone deacetylase 5

2

3

Small-scale

0.584

High

217083

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

336658

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

729249

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

0

High-throughput

0.580

High

885237

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.580

High

1098546

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1098552

TRIP6
Thyroid receptor-interacting protein 6

2

0

High-throughput

0.580

High

1098553

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.580

High

1098554

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.580

High

1098555

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1098557

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.580

High

1098559

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

2

0

High-throughput

0.580

High

1098561

INT11
Integrator complex subunit 11

2

0

High-throughput

0.580

High

1098562

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.580

High

1098573

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

1098604

NDOR1
NADPH-dependent diflavin oxidoreductase 1

2

0

High-throughput

0.580

High

1098610

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

1098606

ATIF1
ATPase inhibitor, mitochondrial

2

0

High-throughput

0.576

High

1098551

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

2

Small-scale

0.561

High

943882

M3KCL
MAP3K7 C-terminal-like protein

1

0

High-throughput

0.558

High

1007631

CCNA1
Cyclin-A1

1

0

Small-scale

0.549

High

1098580

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

413754

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

1067263

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.537

High

703570

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

1098550

CYH1
Cytohesin-1

1

1

High-throughput

0.536

High

1098564

ANR12
Ankyrin repeat domain-containing protein 12

1

1

High-throughput

0.536

High

1098599

EMAL4
Echinoderm microtubule-associated protein-like 4

1

1

High-throughput

0.536

High

1088315

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

1098547

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.518

High

1098583

SPDLY
Protein Spindly

1

0

High-throughput

0.518

High

1098584

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.518

High

1053236

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

837217

ACTY
Beta-centractin

1

0

High-throughput

0.513

High

1098556

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1098602

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

Small-scale

0.486

High

1098544

ASPP2
Apoptosis-stimulating of p53 protein 2

1

1

High-throughput

0.481

High

1098585

ANM6
Protein arginine N-methyltransferase 6

1

0

Small-scale

0.480

High

137536

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

1

Small-scale

0.479

High

142980

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

172767

XPO1
Exportin-1

1

1

High-throughput

0.479

High

239949

SOX15
Transcription factor SOX-15

1

3

High-throughput

0.479

High

341565

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

520005

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

533273

THA
Thyroid hormone receptor alpha

1

4

Small-scale

0.479

High

533339

THB
Thyroid hormone receptor beta

1

4

Small-scale

0.479

High

662223

PAX7
Paired box protein Pax-7

1

4

High-throughput

0.479

High

685183

PAX6
Paired box protein Pax-6

1

4

High-throughput

0.479

High

775838

HNF1B
Hepatocyte nuclear factor 1-beta

1

4

High-throughput

0.479

High

789487

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

High-throughput

0.479

High

872288

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

938444

PAX9
Paired box protein Pax-9

1

4

High-throughput

0.479

High

940948

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.479

High

942096

SOX10
Transcription factor SOX-10

1

4

High-throughput

0.479

High

1040046

PAX2
Paired box protein Pax-2

1

4

High-throughput

0.479

High

1047965

TLE3
Transducin-like enhancer protein 3

1

2

High-throughput

0.479

High

1056602

PAX8
Paired box protein Pax-8

1

4

High-throughput

0.479

High

1091272

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.479

High

1098542

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1098543

CUL4B
Cullin-4B

1

1

Small-scale

0.479

High

1098545

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1098566

RBP10
Ran-binding protein 10

1

1

High-throughput

0.479

High

1098587

NR1H4
Bile acid receptor

1

4

Small-scale

0.479

High

1098595

SOX17
Transcription factor SOX-17

1

3

High-throughput

0.479

High

1098597

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.479

High

1098598

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

1098605

XPO7
Exportin-7

1

1

High-throughput

0.479

High

130456

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

181510

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

371928

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

851546

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

886817

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

894717

EMD
Emerin

1

0

Small-scale

0.458

High

944648

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.458

High

977121

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.458

High

979594

H4
Histone H4

1

0

High-throughput

0.458

High

1098569

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1098571

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1098577

SP7
Transcription factor Sp7

1

0

High-throughput

0.458

High

1098581

LHX4
LIM/homeobox protein Lhx4

1

0

High-throughput

0.458

High

1098588

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

1098596

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1098607

DBNL
Drebrin-like protein

1

0

High-throughput

0.458

High

1098613

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

1098586

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.438

High

896375

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

1098558

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1098578

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.426

High

1098582

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.426

High

1098589

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1098572

SESD1
SEC14 domain and spectrin repeat-containing protein 1

4

0

High-throughput

0.364

High

50330

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

70194

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1098560

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

1098579

UBTD2
Ubiquitin domain-containing protein 2

2

0

High-throughput

0.316

High

1063226

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.282

High

1081577

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.282

High

1098567

WDR87
WD repeat-containing protein 87

1

0

High-throughput

0.279

Low

1098576

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1098591

TDRD1
Tudor domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025