Protein: SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin (EC 3.4.24.-) (EC 3.6.-.-) (Cell matrix adhesion regulator) (Paraplegin) (Spastic paraplegia 7 protein)

Gene: SPG7
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q9UQ90

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1336503

PNMA1
Paraneoplastic antigen Ma1

4

2

High-throughput

0.642

High

1462703

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

3

0

High-throughput

0.629

High

965944

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

6

High-throughput

0.616

High

154910

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

1

High-throughput

0.609

High

1451756

OCAD1
OCIA domain-containing protein 1

2

2

High-throughput

0.601

High

1206033

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

5

High-throughput

0.584

High

1277446

NT2NA
Notch homolog 2 N-terminal-like protein A

2

4

High-throughput

0.578

High

406937

MAS
Proto-oncogene Mas

2

7

High-throughput

0.574

High

771269

APJ
Apelin receptor

2

3

High-throughput

0.574

High

1225734

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

1

High-throughput

0.574

High

1326266

SESQ1
Sesquipedalian-1

2

6

High-throughput

0.574

High

1406352

LPAR4
Lysophosphatidic acid receptor 4

2

6

High-throughput

0.574

High

1462701

GPR55
G-protein coupled receptor 55

2

9

High-throughput

0.558

High

182839

GP182
G-protein coupled receptor 182

2

7

High-throughput

0.549

High

845160

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.549

High

1291922

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

6

High-throughput

0.549

High

1350618

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

1

High-throughput

0.549

High

1100547

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.541

High

174149

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.536

High

210471

MSH5
MutS protein homolog 5

1

1

High-throughput

0.536

High

774710

BASI
Basigin

1

3

High-throughput

0.536

High

1142704

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

1361079

CBPA5
Carboxypeptidase A5

1

1

High-throughput

0.536

High

1364942

AP3S1
AP-3 complex subunit sigma-1

1

8

High-throughput

0.536

High

1372421

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

6

High-throughput

0.536

High

1381097

HDA10
Polyamine deacetylase HDAC10

1

6

High-throughput

0.536

High

1429311

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.536

High

220818

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.523

High

950437

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.523

High

950920

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.523

High

1230314

K1C40
Keratin, type I cytoskeletal 40

1

8

High-throughput

0.523

High

1411381

LZTS2
Leucine zipper putative tumor suppressor 2

1

9

High-throughput

0.523

High

180614

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

340690

STABP
STAM-binding protein

1

0

High-throughput

0.518

High

289341

FCN3
Ficolin-3

1

0

High-throughput

0.513

High

1287669

ACOT1
Acyl-coenzyme A thioesterase 1

1

0

High-throughput

0.513

High

1349988

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

1350921

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1161265

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.508

High

719518

BKRB2
B2 bradykinin receptor

1

6

High-throughput

0.494

High

1410118

KR412
Keratin-associated protein 4-12

1

3

High-throughput

0.494

High

166073

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.489

High

210431

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

380500

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

473510

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

1

High-throughput

0.489

High

538714

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.489

High

574128

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

3

High-throughput

0.489

High

867690

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.489

High

957040

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.489

High

997190

TBA4A
Tubulin alpha-4A chain

1

11

High-throughput

0.489

High

1034850

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.489

High

1116331

PTC1
Protein patched homolog 1

1

4

High-throughput

0.489

High

1136415

EMC2
ER membrane protein complex subunit 2

1

6

High-throughput

0.489

High

1270866

SV2A
Synaptic vesicle glycoprotein 2A

1

3

High-throughput

0.489

High

1309008

S22A9
Organic anion transporter 7

1

2

High-throughput

0.489

High

1325952

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.489

High

1393099

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.489

High

1396957

MRGX4
Mas-related G-protein coupled receptor member X4

1

5

High-throughput

0.489

High

1461855

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.489

High

1462702

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

1141052

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1256131

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1290825

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.479

High

1325326

PALS1
Protein PALS1

1

1

High-throughput

0.479

High

1359205

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.479

High

1367609

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1459805

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

Small-scale

0.479

High

517137

NT2NC
Notch homolog 2 N-terminal-like protein C

1

4

High-throughput

0.470

High

685976

KRA59
Keratin-associated protein 5-9

1

4

High-throughput

0.464

High

898545

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.445

High

1391864

AURKB
Aurora kinase B

1

4

High-throughput

0.445

High

657

NBPFJ
NBPF family member NBPF19

1

3

High-throughput

0.439

High

950035

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

1008573

ELF3
ETS-related transcription factor Elf-3

1

1

High-throughput

0.437

High

1015911

RHOG
Rho-related GTP-binding protein RhoG

1

14

High-throughput

0.437

High

1178469

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1360215

5HT3C
5-hydroxytryptamine receptor 3C

1

1

High-throughput

0.437

High

1386413

FAF2
FAS-associated factor 2

1

11

High-throughput

0.437

High

1411433

CAB45
45 kDa calcium-binding protein

1

4

High-throughput

0.437

High

1434252

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

1217228

RIF1
Telomere-associated protein RIF1

1

5

High-throughput

0.417

High

351263

MOT3
Monocarboxylate transporter 3

1

4

High-throughput

0.407

High

638556

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.407

High

886154

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.407

High

896473

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.407

High

1133821

SL9A5
Sodium/hydrogen exchanger 5

1

1

High-throughput

0.407

High

1236379

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.407

High

1251898

CCNI2
Cyclin-I2

1

2

High-throughput

0.407

High

1346836

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.407

High

1366311

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.407

High

1410636

TBA1C
Tubulin alpha-1C chain

1

12

High-throughput

0.407

High

1434773

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.407

High

1459946

LAT2
Large neutral amino acids transporter small subunit 2

1

2

High-throughput

0.407

High

1407135

MDFI
MyoD family inhibitor

4

0

High-throughput

0.368

High

1349150

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

70535

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

269419

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

1389627

SAAL1
Protein SAAL1

2

0

High-throughput

0.313

High

332603

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.299

High

960612

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.299

High

1219157

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.299

High

1372122

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.299

High

1193240

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.282

High

1461172

RALY
RNA-binding protein Raly

1

0

High-throughput

0.282

High

66951

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

225457

ITM2A
Integral membrane protein 2A

1

0

High-throughput

0.279

Low

260990

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

469573

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

549921

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

868028

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

1251700

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1273301

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

1363257

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1390807

PGAP3
GPI-specific phospholipase A2-like PGAP3

1

0

High-throughput

0.279

Low

1413876

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

1420790

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.279

Low

1462255

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.279

Low

1462700

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

320417

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.251

Low

1212481

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

1108519

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.249

Low

1395043

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low

132930

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.232

Low

1242273

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1389485

NTCP4
Sodium/bile acid cotransporter 4

1

0

High-throughput

0.232

Low

1412968

FUZZY
Protein fuzzy homolog

1

0

High-throughput

0.232

Low

1420123

CHIA
Acidic mammalian chitinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025