Protein: WAPL
Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor)

Gene: WAPL
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q7Z5K2

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1279186

WAPL
Wings apart-like protein homolog

3

0

High-throughput

0.811

High

1279199

STAG2
Cohesin subunit SA-2

9

2

Small-scale

0.754

High

1130088

SMC1A
Structural maintenance of chromosomes protein 1A

7

2

Small-scale

0.749

High

1279252

SMC3
Structural maintenance of chromosomes protein 3

7

2

Small-scale

0.746

High

1177586

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

6

2

Small-scale

0.736

High

1279207

STAG1
Cohesin subunit SA-1

6

2

Small-scale

0.730

High

238549

RAD21
Double-strand-break repair protein rad21 homolog

11

0

Small-scale

0.726

High

1279239

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

5

3

Small-scale

0.718

High

170214

AURKA
Aurora kinase A

4

1

High-throughput

0.694

High

1279202

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

3

0

High-throughput

0.638

High

1030793

DEF5
Defensin alpha 5

3

0

High-throughput

0.634

High

1279216

CDCA5
Sororin

3

0

Small-scale

0.632

High

558235

XRCC6
X-ray repair cross-complementing protein 6

3

0

High-throughput

0.613

High

279407

TULP3
Tubby-related protein 3

2

0

High-throughput

0.602

High

1279248

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

372428

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

589036

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

920075

PLK1
Serine/threonine-protein kinase PLK1

2

1

High-throughput

0.584

High

998485

H31
Histone H3.1

2

1

High-throughput

0.584

High

695823

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768535

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

830989

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

1279200

SIR6
NAD-dependent protein deacylase sirtuin-6

2

0

Small-scale

0.559

High

1279214

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

0

Small-scale

0.559

High

1279247

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

210404

MTLR
Motilin receptor

1

1

High-throughput

0.536

High

288108

FOXH1
Forkhead box protein H1

1

2

High-throughput

0.536

High

1116516

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.536

High

1123019

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.536

High

1250416

KSR2
Kinase suppressor of Ras 2

1

1

High-throughput

0.536

High

1253570

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.536

High

1279225

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.536

High

1279231

REN3A
Regulator of nonsense transcripts 3A

1

1

High-throughput

0.536

High

1279259

TEST
Testisin

1

1

High-throughput

0.536

High

1123512

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

923605

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.513

High

1042584

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

High-throughput

0.513

High

1093261

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.513

High

1094781

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.513

High

1109544

CROC4
Protein CROC-4

1

0

High-throughput

0.513

High

1111068

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1161128

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

1204369

SGO1
Shugoshin 1

1

0

Small-scale

0.513

High

1279215

ATG4C
Cysteine protease ATG4C

1

0

High-throughput

0.513

High

1279218

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.513

High

1279232

E41LB
Band 4.1-like protein 4B

1

0

High-throughput

0.513

High

1279235

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1279237

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1279240

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

1279187

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.493

High

1279224

CML1
Chemerin-like receptor 1

1

2

High-throughput

0.489

High

1279196

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.486

High

964349

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

285977

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.479

High

346005

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

520166

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

535240

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

693816

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

754892

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

799246

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

857138

NSF
Vesicle-fusing ATPase

1

1

High-throughput

0.479

High

862260

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

937283

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

2

High-throughput

0.479

High

980881

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

996747

TBA1B
Tubulin alpha-1B chain

1

1

High-throughput

0.479

High

1008788

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

1016984

H33
Histone H3.3

1

1

High-throughput

0.479

High

1096738

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1119839

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.479

High

1279194

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1279195

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

1279210

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.479

High

1279212

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1279226

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.479

High

1279229

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1279244

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

1

High-throughput

0.479

High

1279250

STAG3
Cohesin subunit SA-3

1

2

High-throughput

0.479

High

1279220

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

0

Small-scale

0.460

High

129219

MEN1
Menin

1

0

High-throughput

0.458

High

162614

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.458

High

174545

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.458

High

260127

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

289596

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.458

High

385902

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

508203

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

537418

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

587714

DESP
Desmoplakin

1

0

High-throughput

0.458

High

637600

FLNA
Filamin-A

1

0

High-throughput

0.458

High

655248

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.458

High

697161

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

729329

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.458

High

837690

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

841812

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

846364

MATR3
Matrin-3

1

0

High-throughput

0.458

High

879227

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

881556

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

934798

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

958981

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

979031

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

985742

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

991872

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

996221

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

1005899

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

1023099

RBM10
RNA-binding protein 10

1

0

High-throughput

0.458

High

1032353

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.458

High

1032495

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1045452

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1097388

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1106983

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1113536

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1138353

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1144700

PWP2
Periodic tryptophan protein 2 homolog

1

0

High-throughput

0.458

High

1147932

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.458

High

1164297

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

0

High-throughput

0.458

High

1198067

FA98B
Protein FAM98B

1

0

High-throughput

0.458

High

1204002

FILA2
Filaggrin-2

1

0

High-throughput

0.458

High

1235643

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

1254423

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1276420

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1279188

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1279191

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.458

High

1279192

MGAP
MAX gene-associated protein

1

0

High-throughput

0.458

High

1279201

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1279203

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1279204

WDR48
WD repeat-containing protein 48

1

0

High-throughput

0.458

High

1279206

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1279208

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

1279209

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1279213

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.458

High

1279219

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1279221

RBM15
RNA-binding protein 15

1

0

High-throughput

0.458

High

1279230

DDX47
Probable ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.458

High

1279233

DEFI6
Differentially expressed in FDCP 6 homolog

1

0

High-throughput

0.458

High

1279234

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1279241

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1279243

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1279245

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.458

High

1279249

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1279251

BRPF3
Bromodomain and PHD finger-containing protein 3

1

0

High-throughput

0.458

High

1279253

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

1279255

PKP3
Plakophilin-3

1

0

High-throughput

0.458

High

1279256

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1279257

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.458

High

1279260

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

107405

F8W7C6
Ribosomal protein L10

1

1

High-throughput

0.445

High

638462

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.445

High

1279211

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

1279217

AURKB
Aurora kinase B

1

1

High-throughput

0.445

High

1279223

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

941799

ARL4C
ADP-ribosylation factor-like protein 4C

1

0

High-throughput

0.426

High

1279045

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

437717

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

835312

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.407

High

880168

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.407

High

909446

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

0

High-throughput

0.347

High

1279189

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

1279193

DJC10
DnaJ homolog subfamily C member 10

3

0

High-throughput

0.347

High

587353

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.328

High

1279258

SO1B1
Solute carrier organic anion transporter family member 1B1

2

0

High-throughput

0.328

High

1101560

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

0

High-throughput

0.313

High

1180282

ATG2A
Autophagy-related protein 2 homolog A

1

0

High-throughput

0.279

Low

1181022

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1208220

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1249801

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1279190

ZSWM9
Uncharacterized protein ZSWIM9

1

0

High-throughput

0.279

Low

1279222

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1279228

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1279236

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1279254

CCL26
C-C motif chemokine 26

1

0

High-throughput

0.279

Low

869764

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

412175

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

420591

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

1010657

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1248973

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1279197

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.249

Low

1279242

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.249

Low

640206

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.232

Low

704034

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1279198

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

1279205

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low

1279227

SFXN3
Sideroflexin-3

1

0

High-throughput

0.232

Low

1279238

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low

1279246

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025